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Conference Paper: Chronic intermittent hypoxia induces oxidative stress and inflammation via Angiotensin II Receptor 1 in rat liver

TitleChronic intermittent hypoxia induces oxidative stress and inflammation via Angiotensin II Receptor 1 in rat liver
Authors
Pan, JXiao, JTipoe, GLFung, ML
Issue Date2012
PublisherThe Chinese University of Hong Kong.
Citation
The 2012 Hong Kong-Taiwan Physiology Symposium and joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong (HKSN-BSHK), Hong Kong, 14-15 June 2012. In Program Book, 2012, p. 53, abstract no. P17 How to Cite?
AbstractChronic intermittent hypoxia (IH) associated with obstructive sleep apnea (OSA) is characterized by repetitive cycles of hypoxia and reoxygenation, leading to excessive production of reactive oxygen species and oxidative stress in tissues and organs. However the mechanistic effects of chronic IH on the liver are not clear at present. We hypothesized that renin-angiotensin system (RAS) plays a role in the IH-induced oxidative stress and tissue inflammation in the rat liver. Adult Sprague-Dawley rats were exposed to air (normoxic (Nx) control) or IH treatment (with inspired oxygen fraction in the normobaric chamber cyclic between 5-21% ± 0.5% per min, 8 hours per day) for 14 days. Rats were fed with an angiotensin II type 1 (AT1) receptors blocker telmisartan (10mg/kg body weight), or vehicle daily before the IH treatment. Hepatic expression levels of pro-inflammatory …
DescriptionPoster Presentation: no. P17
Persistent Identifierhttp://hdl.handle.net/10722/165031

 

DC FieldValueLanguage
dc.contributor.authorPan, Jen_US
dc.contributor.authorXiao, Jen_US
dc.contributor.authorTipoe, GLen_US
dc.contributor.authorFung, MLen_US
dc.date.accessioned2012-09-20T08:13:44Z-
dc.date.available2012-09-20T08:13:44Z-
dc.date.issued2012en_US
dc.identifier.citationThe 2012 Hong Kong-Taiwan Physiology Symposium and joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong (HKSN-BSHK), Hong Kong, 14-15 June 2012. In Program Book, 2012, p. 53, abstract no. P17en_US
dc.identifier.urihttp://hdl.handle.net/10722/165031-
dc.descriptionPoster Presentation: no. P17-
dc.description.abstractChronic intermittent hypoxia (IH) associated with obstructive sleep apnea (OSA) is characterized by repetitive cycles of hypoxia and reoxygenation, leading to excessive production of reactive oxygen species and oxidative stress in tissues and organs. However the mechanistic effects of chronic IH on the liver are not clear at present. We hypothesized that renin-angiotensin system (RAS) plays a role in the IH-induced oxidative stress and tissue inflammation in the rat liver. Adult Sprague-Dawley rats were exposed to air (normoxic (Nx) control) or IH treatment (with inspired oxygen fraction in the normobaric chamber cyclic between 5-21% ± 0.5% per min, 8 hours per day) for 14 days. Rats were fed with an angiotensin II type 1 (AT1) receptors blocker telmisartan (10mg/kg body weight), or vehicle daily before the IH treatment. Hepatic expression levels of pro-inflammatory …-
dc.languageengen_US
dc.publisherThe Chinese University of Hong Kong.-
dc.relation.ispartofHong Kong-Taiwan Physiology Symposium & HKSN-BSHK 2012 Joint Scientific Meetingen_US
dc.titleChronic intermittent hypoxia induces oxidative stress and inflammation via Angiotensin II Receptor 1 in rat liveren_US
dc.typeConference_Paperen_US
dc.identifier.emailTipoe, GL: tgeorge@hkucc.hku.hken_US
dc.identifier.emailFung, ML: fungml@hkucc.hku.hken_US
dc.identifier.authorityTipoe, GL=rp00371en_US
dc.identifier.authorityFung, ML=rp00433en_US
dc.description.naturepostprint-
dc.identifier.hkuros209970en_US
dc.identifier.spage53, abstract no. P17-
dc.identifier.epage53, abstract no. P17-
dc.publisher.placeHong Kong-

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