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- Publisher Website: 10.1016/0014-4827(79)90318-5
- Scopus: eid_2-s2.0-0018598654
- PMID: 510408
- WOS: WOS:A1979HQ77300019
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Article: Appearance of β-adrenergic response of adenylate cyclase during the induction of differentiation in cell cultures
Title | Appearance of β-adrenergic response of adenylate cyclase during the induction of differentiation in cell cultures |
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Authors | |
Issue Date | 1979 |
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexcr |
Citation | Experimental Cell Research, 1979, v. 122 n. 2, p. 399-402 How to Cite? |
Abstract | Chemical inducers of differentiation, such as dimethylsulfoxide, N-methylacetamide and sodium butyrate, induce various kinds of differentiated characteristics in tumor cell lines as shown by numerous studies. In this study we showed that one common property of this group of chemicals is their ability to induce β-adrenergic response of adenylate cyclase in cell cultures, including Friend erythroleukemic cells, HeLa cells and rat fetal hepatocytes. This induction appears to be an early event in the differentiation, since it precedes the appearance of other differentiated characteristics, such as hemoglobin synthesis in erythroleukemic cells. This induced hormone response may contribute to the regulation of subsequent steps of differentiation. |
Persistent Identifier | http://hdl.handle.net/10722/167446 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 0.947 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lin, CS | en_US |
dc.contributor.author | Lin, MC | en_US |
dc.date.accessioned | 2012-10-08T03:07:05Z | - |
dc.date.available | 2012-10-08T03:07:05Z | - |
dc.date.issued | 1979 | en_US |
dc.identifier.citation | Experimental Cell Research, 1979, v. 122 n. 2, p. 399-402 | en_US |
dc.identifier.issn | 0014-4827 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/167446 | - |
dc.description.abstract | Chemical inducers of differentiation, such as dimethylsulfoxide, N-methylacetamide and sodium butyrate, induce various kinds of differentiated characteristics in tumor cell lines as shown by numerous studies. In this study we showed that one common property of this group of chemicals is their ability to induce β-adrenergic response of adenylate cyclase in cell cultures, including Friend erythroleukemic cells, HeLa cells and rat fetal hepatocytes. This induction appears to be an early event in the differentiation, since it precedes the appearance of other differentiated characteristics, such as hemoglobin synthesis in erythroleukemic cells. This induced hormone response may contribute to the regulation of subsequent steps of differentiation. | en_US |
dc.language | eng | en_US |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexcr | en_US |
dc.relation.ispartof | Experimental Cell Research | en_US |
dc.subject.mesh | Acetamides - Pharmacology | en_US |
dc.subject.mesh | Adenylate Cyclase - Metabolism | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Butyrates - Pharmacology | en_US |
dc.subject.mesh | Cell Differentiation - Drug Effects | en_US |
dc.subject.mesh | Cell Line | en_US |
dc.subject.mesh | Dimethyl Sulfoxide - Pharmacology | en_US |
dc.subject.mesh | Enzyme Activation - Drug Effects | en_US |
dc.subject.mesh | Follicle Stimulating Hormone - Biosynthesis | en_US |
dc.subject.mesh | Friend Murine Leukemia Virus | en_US |
dc.subject.mesh | Hela Cells | en_US |
dc.subject.mesh | Hemoglobins - Biosynthesis | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Isoproterenol - Pharmacology | en_US |
dc.subject.mesh | Leukemia, Experimental | en_US |
dc.subject.mesh | Liver - Embryology | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Rats | en_US |
dc.title | Appearance of β-adrenergic response of adenylate cyclase during the induction of differentiation in cell cultures | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lin, MC:mcllin@hkucc.hku.hk | en_US |
dc.identifier.authority | Lin, MC=rp00746 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0014-4827(79)90318-5 | - |
dc.identifier.pmid | 510408 | - |
dc.identifier.scopus | eid_2-s2.0-0018598654 | en_US |
dc.identifier.volume | 122 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 399 | en_US |
dc.identifier.epage | 402 | en_US |
dc.identifier.isi | WOS:A1979HQ77300019 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lin, CS=24540146100 | en_US |
dc.identifier.scopusauthorid | Lin, MC=7404816359 | en_US |
dc.identifier.issnl | 0014-4827 | - |