Synthesis and characterization of iron and manganese porphyrin complexes with amino-acid-esters as axial ligand

Abstract

The new six-coordinate complexes (TPP)Fe1 (Gly-OMe)2 C50H42FeN6O4 and (TPP)Fe1 (β-Ala-OMe)2(C52H46FeN6O 4) wbere TPP=meso-tetraphenyl porphyrinate, Gly-OMe=glycine methyl ester, β-Ala-OMe=β-alanine methyl ester and five-coordinte complex (TPP)Mn1 (Gly-OMe) (C47H35MnN5O2) have been prepared by sodium borohydride method. These complexes were characterized by UV-Vis, IR, ESR, spectra and by elemental analysis. The synthesized divalent iron porphyrins are d6 low spin states and their UV-Vis spectra are Hypso type; while divalent manganese porphyrin is d5 high spin state and its UV-Vis spectrum is pseudo-Normal type.

以氨基酸酯為軸向配體的鐵、錳卟啉配合物的合成及表徵穆林靜＊邱曉航周永洽黃傑生申泮文（南開大學化學系，天津３０００７１）關鍵詞：鐵卟啉錳卟啉氨基酸酯合成表徵氨基酸酯是一類最基本的生物分子，有廣泛形成配合物的能力。研究發現，二價鋅卟啉可識別氨基酸酯，三價的銠卟啉可與氨基酸的氨基、羧基作用[1,2]。研究中還發現, 制約P450酶催化活性的因素, 主要取決於與之鄰近的配體, 末端的氨基酸殘基和蛋白質本身[3] 。因此合成軸向為氨基酸酯的鐵、錳卟啉配合物對進一步瞭解P450酶具有一定意義。