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Article: Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus
Title | Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus |
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Authors | |
Keywords | HBV Immunity TNF-α |
Issue Date | 2005 |
Publisher | Baishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm |
Citation | World Journal Of Gastroenterology, 2005, v. 11 n. 48, p. 7564-7568 How to Cite? |
Abstract | Aim: To compare the gene expression profile in a pair of HBV-infected twins. Methods: The gene expression profile was compared in a pair of H BV-infected twins. Results: The twins displayed different disease outco mes. One acquired natural immunity against HBV, whereas the other became a chronic HBV carrier. Eighty-eight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RT-PCR. However, upon HBV core antigen stimulation, TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+ channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins. Conclusion: TNF-αIP1 may play a role in the innate immunity against HBV. © 2005 The WJG Press and Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/167999 |
ISSN | 2023 Impact Factor: 4.3 2023 SCImago Journal Rankings: 1.063 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lin, MC | en_US |
dc.contributor.author | Lee, NP | en_US |
dc.contributor.author | Zheng, N | en_US |
dc.contributor.author | Yang, PH | en_US |
dc.contributor.author | Wong, OG | en_US |
dc.contributor.author | Kung, HF | en_US |
dc.contributor.author | Hui, CK | en_US |
dc.contributor.author | Luk, JM | en_US |
dc.contributor.author | Lau, GKK | en_US |
dc.date.accessioned | 2012-10-08T03:13:57Z | - |
dc.date.available | 2012-10-08T03:13:57Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | World Journal Of Gastroenterology, 2005, v. 11 n. 48, p. 7564-7568 | en_US |
dc.identifier.issn | 1007-9327 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/167999 | - |
dc.description.abstract | Aim: To compare the gene expression profile in a pair of HBV-infected twins. Methods: The gene expression profile was compared in a pair of H BV-infected twins. Results: The twins displayed different disease outco mes. One acquired natural immunity against HBV, whereas the other became a chronic HBV carrier. Eighty-eight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RT-PCR. However, upon HBV core antigen stimulation, TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+ channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins. Conclusion: TNF-αIP1 may play a role in the innate immunity against HBV. © 2005 The WJG Press and Elsevier Inc. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Baishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm | en_US |
dc.relation.ispartof | World Journal of Gastroenterology | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | HBV | - |
dc.subject | Immunity | - |
dc.subject | TNF-α | - |
dc.subject.mesh | Amino Acid Sequence | en_US |
dc.subject.mesh | Diseases In Twins | en_US |
dc.subject.mesh | Gene Expression Profiling | en_US |
dc.subject.mesh | Gene Expression Regulation | en_US |
dc.subject.mesh | Hepatitis B Virus - Immunology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Immunity, Innate | en_US |
dc.subject.mesh | Interleukin-18 Receptor Alpha Subunit | en_US |
dc.subject.mesh | Molecular Sequence Data | en_US |
dc.subject.mesh | Proteins - Genetics - Physiology | en_US |
dc.subject.mesh | Receptors, Interleukin - Genetics | en_US |
dc.subject.mesh | Receptors, Interleukin-18 | en_US |
dc.title | Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lin, MC:mcllin@hkucc.hku.hk | en_US |
dc.identifier.email | Lee, NP:nikkilee@hku.hk | en_US |
dc.identifier.email | Luk, JM:jmluk@hkucc.hku.hk | en_US |
dc.identifier.authority | Lin, MC=rp00746 | en_US |
dc.identifier.authority | Lee, NP=rp00263 | en_US |
dc.identifier.authority | Luk, JM=rp00349 | en_US |
dc.description.nature | published_or_final_version | en_US |
dc.identifier.doi | 10.3748/wjg.v11.i48.7564 | - |
dc.identifier.pmid | 16437679 | - |
dc.identifier.scopus | eid_2-s2.0-31644438942 | en_US |
dc.identifier.hkuros | 115689 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-31644438942&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | 48 | en_US |
dc.identifier.spage | 7564 | en_US |
dc.identifier.epage | 7568 | en_US |
dc.identifier.isi | WOS:000208157800003 | - |
dc.publisher.place | China | en_US |
dc.identifier.scopusauthorid | Lin, MC=7404816359 | en_US |
dc.identifier.scopusauthorid | Lee, NP=7402722690 | en_US |
dc.identifier.scopusauthorid | Zheng, N=36724059100 | en_US |
dc.identifier.scopusauthorid | Yang, PH=24340289000 | en_US |
dc.identifier.scopusauthorid | Wong, OG=7004813981 | en_US |
dc.identifier.scopusauthorid | Kung, HF=7402514190 | en_US |
dc.identifier.scopusauthorid | Hui, CK=7202876933 | en_US |
dc.identifier.scopusauthorid | Luk, JM=7006777791 | en_US |
dc.identifier.scopusauthorid | Lau, GKK=7102301257 | en_US |
dc.identifier.issnl | 1007-9327 | - |