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Article: Single nucleotide polymorphism of rs430397 in the fifth intron of GRP78 gene and clinical relevance of primary hepatocellular carcinoma in Han Chinese: Risk and prognosis
Title | Single nucleotide polymorphism of rs430397 in the fifth intron of GRP78 gene and clinical relevance of primary hepatocellular carcinoma in Han Chinese: Risk and prognosis |
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Authors | |
Keywords | Glucose-regulated protein 78 Hepatocellular carcinoma Prognosis Risk Single-nucleotide polymorphism |
Issue Date | 2009 |
Publisher | John Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home |
Citation | International Journal Of Cancer, 2009, v. 125 n. 6, p. 1352-1357 How to Cite? |
Abstract | Large number of data showed that allele variants in certain genes are markers for hepatocellular carcinoma (HCC). GRP78 is a stress-associated protein which is a central regulator of endoplasmic reticulum homeostasis due to its multiple functional roles in the folding, maturation and transport of proteins. A case-control study was conducted on 576 HCC patients, and 539 age- and gender-matched healthy subjects to examine whether rs430397 polymorphism in the fifth intron of GRP78 gene is associated with the development and prognosis of HCC. Polymorphism in rs430397 was analyzed by resequencing and TaqMan real-time PCR. Allele A, genotype AA and combined genotypes (AG1AA) displayed significantly increased risk for HCC (OR = 1.48, 95%CI = 1.07-1.79, p = 0.010; OR = 2.25, 95%CI= 1.08-3.38, p = 0.019; and OR = 1.50, 95%CI = 1.09-1.85, p = 0.012, respectively). Genotypes AA and AG were mainly associated with HBV-related HCC (85.8%; p < 0.00001 versus HBV noncarriers with HCC) and cirrhosis-related HCC (90%; p = 0.011 versus noncirrhosis HCC). Patients carrying the AA genotype had a shorter survival time (median 23.0 months in all cases; median 21.0 months in the cases carrying HBsAg). Like HBV and cirrhosis, the rs430397 is an independent prognostic factor influencing the survival of HCC. In conclusion, allele A and genotypes AA and AG of rs430397 may represent high risk and poor prognosis for HCC. © 2009 UICC. |
Persistent Identifier | http://hdl.handle.net/10722/168396 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 2.131 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhu, X | en_US |
dc.contributor.author | Chen, MS | en_US |
dc.contributor.author | Tian, LW | en_US |
dc.contributor.author | Li, DP | en_US |
dc.contributor.author | Xu, PL | en_US |
dc.contributor.author | Lin, MCM | en_US |
dc.contributor.author | Xie, D | en_US |
dc.contributor.author | Kung, HF | en_US |
dc.date.accessioned | 2012-10-08T03:18:25Z | - |
dc.date.available | 2012-10-08T03:18:25Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | International Journal Of Cancer, 2009, v. 125 n. 6, p. 1352-1357 | en_US |
dc.identifier.issn | 0020-7136 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/168396 | - |
dc.description.abstract | Large number of data showed that allele variants in certain genes are markers for hepatocellular carcinoma (HCC). GRP78 is a stress-associated protein which is a central regulator of endoplasmic reticulum homeostasis due to its multiple functional roles in the folding, maturation and transport of proteins. A case-control study was conducted on 576 HCC patients, and 539 age- and gender-matched healthy subjects to examine whether rs430397 polymorphism in the fifth intron of GRP78 gene is associated with the development and prognosis of HCC. Polymorphism in rs430397 was analyzed by resequencing and TaqMan real-time PCR. Allele A, genotype AA and combined genotypes (AG1AA) displayed significantly increased risk for HCC (OR = 1.48, 95%CI = 1.07-1.79, p = 0.010; OR = 2.25, 95%CI= 1.08-3.38, p = 0.019; and OR = 1.50, 95%CI = 1.09-1.85, p = 0.012, respectively). Genotypes AA and AG were mainly associated with HBV-related HCC (85.8%; p < 0.00001 versus HBV noncarriers with HCC) and cirrhosis-related HCC (90%; p = 0.011 versus noncirrhosis HCC). Patients carrying the AA genotype had a shorter survival time (median 23.0 months in all cases; median 21.0 months in the cases carrying HBsAg). Like HBV and cirrhosis, the rs430397 is an independent prognostic factor influencing the survival of HCC. In conclusion, allele A and genotypes AA and AG of rs430397 may represent high risk and poor prognosis for HCC. © 2009 UICC. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home | en_US |
dc.relation.ispartof | International Journal of Cancer | en_US |
dc.subject | Glucose-regulated protein 78 | - |
dc.subject | Hepatocellular carcinoma | - |
dc.subject | Prognosis | - |
dc.subject | Risk | - |
dc.subject | Single-nucleotide polymorphism | - |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Asian Continental Ancestry Group - Genetics | en_US |
dc.subject.mesh | Carcinoma, Hepatocellular - Complications - Genetics - Virology | en_US |
dc.subject.mesh | Case-Control Studies | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Genotype | en_US |
dc.subject.mesh | Heat-Shock Proteins - Genetics | en_US |
dc.subject.mesh | Hepatitis B - Complications - Genetics | en_US |
dc.subject.mesh | Hepatitis B Virus - Physiology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Introns - Genetics | en_US |
dc.subject.mesh | Liver Neoplasms - Complications - Genetics - Virology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Neoplasm Staging | en_US |
dc.subject.mesh | Polymorphism, Single Nucleotide - Genetics | en_US |
dc.subject.mesh | Prognosis | en_US |
dc.subject.mesh | Risk Factors | en_US |
dc.subject.mesh | Survival Rate | en_US |
dc.title | Single nucleotide polymorphism of rs430397 in the fifth intron of GRP78 gene and clinical relevance of primary hepatocellular carcinoma in Han Chinese: Risk and prognosis | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lin, MCM:mcllin@hkucc.hku.hk | en_US |
dc.identifier.authority | Lin, MCM=rp00746 | en_US |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.doi | 10.1002/ijc.24487 | en_US |
dc.identifier.pmid | 19533686 | - |
dc.identifier.scopus | eid_2-s2.0-68249154796 | en_US |
dc.identifier.hkuros | 162977 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-68249154796&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 125 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 1352 | en_US |
dc.identifier.epage | 1357 | en_US |
dc.identifier.isi | WOS:000269392700013 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Zhu, X=23491117800 | en_US |
dc.identifier.scopusauthorid | Chen, MS=24333976200 | en_US |
dc.identifier.scopusauthorid | Tian, LW=7202296490 | en_US |
dc.identifier.scopusauthorid | Li, DP=24463373900 | en_US |
dc.identifier.scopusauthorid | Xu, PL=7202215533 | en_US |
dc.identifier.scopusauthorid | Lin, MCM=7404816359 | en_US |
dc.identifier.scopusauthorid | Xie, D=35070710200 | en_US |
dc.identifier.scopusauthorid | Kung, HF=7402514190 | en_US |
dc.identifier.issnl | 0020-7136 | - |