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Article: A natural product-like inhibitor of NEDD8-activating enzyme

TitleA natural product-like inhibitor of NEDD8-activating enzyme
Authors
Leung, CHChan, DSHYang, HAbagyan, RLee, SMYZhu, GYFong, WFMa, DL
Issue Date2011
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp
Citation
Chemical Communications, 2011, v. 47 n. 9, p. 2511-2513 How to Cite?
DOI: http://dx.doi.org/10.1039/c0cc04927a
AbstractThe natural product-like 6,6″-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range. © 2011 The Royal Society of Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/168513
ISSN
1359-7345
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 1.133
ISI Accession Number ID
WOS:000287409800004
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLeung, CHen_US
dc.contributor.authorChan, DSHen_US
dc.contributor.authorYang, Hen_US
dc.contributor.authorAbagyan, Ren_US
dc.contributor.authorLee, SMYen_US
dc.contributor.authorZhu, GYen_US
dc.contributor.authorFong, WFen_US
dc.contributor.authorMa, DLen_US
dc.date.accessioned2012-10-08T03:19:51Z-
dc.date.available2012-10-08T03:19:51Z-
dc.date.issued2011en_US
dc.identifier.citationChemical Communications, 2011, v. 47 n. 9, p. 2511-2513en_US
dc.identifier.issn1359-7345en_US
dc.identifier.urihttp://hdl.handle.net/10722/168513-
dc.description.abstractThe natural product-like 6,6″-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range. © 2011 The Royal Society of Chemistry.en_US
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.aspen_US
dc.relation.ispartofChemical Communicationsen_US
dc.subject.meshApigenin - Chemistryen_US
dc.subject.meshBiflavonoids - Chemistryen_US
dc.subject.meshBinding Sitesen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshComputer Simulationen_US
dc.subject.meshCyclopentanes - Chemistryen_US
dc.subject.meshDrug Designen_US
dc.subject.meshHumansen_US
dc.subject.meshPyrimidines - Chemistryen_US
dc.subject.meshUbiquitins - Antagonists & Inhibitors - Metabolismen_US
dc.titleA natural product-like inhibitor of NEDD8-activating enzymeen_US
dc.typeArticleen_US
dc.identifier.emailLeung, CH:duncanl@hkucc.hku.hken_US
dc.identifier.emailMa, DL:edmondma@hku.hken_US
dc.identifier.authorityLeung, CH=rp00730en_US
dc.identifier.authorityMa, DL=rp00760en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1039/c0cc04927aen_US
dc.identifier.pmid21240405en_US
dc.identifier.scopuseid_2-s2.0-79952261355en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952261355&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume47en_US
dc.identifier.issue9en_US
dc.identifier.spage2511en_US
dc.identifier.epage2513en_US
dc.identifier.isiWOS:000287409800004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLeung, CH=7402612570en_US
dc.identifier.scopusauthoridChan, DSH=35285471900en_US
dc.identifier.scopusauthoridYang, H=36653320200en_US
dc.identifier.scopusauthoridAbagyan, R=7006710879en_US
dc.identifier.scopusauthoridLee, SMY=35233892600en_US
dc.identifier.scopusauthoridZhu, GY=7402633140en_US
dc.identifier.scopusauthoridFong, WF=7102816013en_US
dc.identifier.scopusauthoridMa, DL=7402075538en_US
dc.identifier.issnl1359-7345-

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