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Article: An intronic variant in the GRP78, a stress-associated gene, improves prediction for liver cirrhosis in persistent HBV carriers
Title | An intronic variant in the GRP78, a stress-associated gene, improves prediction for liver cirrhosis in persistent HBV carriers |
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Authors | |
Issue Date | 2011 |
Publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action |
Citation | Plos One, 2011, v. 6 n. 7 How to Cite? |
Abstract | Background: Our previous study indicated that a common variant (rs430397 G>A) in the intron 5 of glucose-regulated protein 78 (GRP78) gene was associated with risk and prognosis of primary hepatocellular carcinoma (HCC), including HBV- and cirrhosis-related HCC. rs430397 polymorphism may be a contributing factor or biomarker of HBV infection or HBV-related cirrhosis. Methodology/Principal Findings: 539 non-HBV-infected individuals, 205 self-limited infection and 496 persistent HBV infection were recruited between January 2001 and April 2005 from the hospitals in Southern China. Genomic DNA was genotyped for rs430397. The associations between the variation and susceptibility to liver cirrhosis (LC) in persistent HBV infection were examined. We observed that individuals carrying allele rs430397A were more likely to become HBV-related LC. When persistently infected patients were divided into four subgroups, patients with phase IV had an increased allele A and genotype AG compared with phase I and/or phase III. Decreased serum albumin and prolonged plasma prothrombin time (PT) were showed in LC patients carrying genotype AA. Furthermore, rs430397 genotype had an increased susceptibility to LC with dose-dependent manners (P-trend = 0.005), and the genotype did constitute a risk factor for the development of advanced LC (Child-Pugh classification C and B, P-trend = 0.021). Conclusions/Significance: rs430397 polymorphism may be a contributing factor to LC in persistent HBV carriers. © 2011 Zhu et al. |
Persistent Identifier | http://hdl.handle.net/10722/168540 |
ISSN | 2021 Impact Factor: 3.752 2020 SCImago Journal Rankings: 0.990 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Zhu, X | en_US |
dc.contributor.author | Chen, L | en_US |
dc.contributor.author | Fan, W | en_US |
dc.contributor.author | Lin, MCM | en_US |
dc.contributor.author | Tian, L | en_US |
dc.contributor.author | Wang, M | en_US |
dc.contributor.author | Lin, S | en_US |
dc.contributor.author | Wang, Z | en_US |
dc.contributor.author | Zhang, J | en_US |
dc.contributor.author | Wang, J | en_US |
dc.contributor.author | Yao, H | en_US |
dc.contributor.author | Kung, H | en_US |
dc.contributor.author | Li, D | en_US |
dc.date.accessioned | 2012-10-08T03:20:20Z | - |
dc.date.available | 2012-10-08T03:20:20Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Plos One, 2011, v. 6 n. 7 | en_US |
dc.identifier.issn | 1932-6203 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/168540 | - |
dc.description.abstract | Background: Our previous study indicated that a common variant (rs430397 G>A) in the intron 5 of glucose-regulated protein 78 (GRP78) gene was associated with risk and prognosis of primary hepatocellular carcinoma (HCC), including HBV- and cirrhosis-related HCC. rs430397 polymorphism may be a contributing factor or biomarker of HBV infection or HBV-related cirrhosis. Methodology/Principal Findings: 539 non-HBV-infected individuals, 205 self-limited infection and 496 persistent HBV infection were recruited between January 2001 and April 2005 from the hospitals in Southern China. Genomic DNA was genotyped for rs430397. The associations between the variation and susceptibility to liver cirrhosis (LC) in persistent HBV infection were examined. We observed that individuals carrying allele rs430397A were more likely to become HBV-related LC. When persistently infected patients were divided into four subgroups, patients with phase IV had an increased allele A and genotype AG compared with phase I and/or phase III. Decreased serum albumin and prolonged plasma prothrombin time (PT) were showed in LC patients carrying genotype AA. Furthermore, rs430397 genotype had an increased susceptibility to LC with dose-dependent manners (P-trend = 0.005), and the genotype did constitute a risk factor for the development of advanced LC (Child-Pugh classification C and B, P-trend = 0.021). Conclusions/Significance: rs430397 polymorphism may be a contributing factor to LC in persistent HBV carriers. © 2011 Zhu et al. | en_US |
dc.language | eng | en_US |
dc.publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action | en_US |
dc.relation.ispartof | PLoS ONE | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | An intronic variant in the GRP78, a stress-associated gene, improves prediction for liver cirrhosis in persistent HBV carriers | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lin, MCM:mcllin@hkucc.hku.hk | en_US |
dc.identifier.authority | Lin, MCM=rp00746 | en_US |
dc.description.nature | published_or_final_version | en_US |
dc.identifier.doi | 10.1371/journal.pone.0021997 | en_US |
dc.identifier.pmid | 21779363 | - |
dc.identifier.scopus | eid_2-s2.0-79960292957 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-79960292957&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.isi | WOS:000292811300033 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Zhu, X=23491117800 | en_US |
dc.identifier.scopusauthorid | Chen, L=37112067500 | en_US |
dc.identifier.scopusauthorid | Fan, W=24070406000 | en_US |
dc.identifier.scopusauthorid | Lin, MCM=7404816359 | en_US |
dc.identifier.scopusauthorid | Tian, L=7202296490 | en_US |
dc.identifier.scopusauthorid | Wang, M=46261729500 | en_US |
dc.identifier.scopusauthorid | Lin, S=46261455900 | en_US |
dc.identifier.scopusauthorid | Wang, Z=46261621900 | en_US |
dc.identifier.scopusauthorid | Zhang, J=46261770200 | en_US |
dc.identifier.scopusauthorid | Wang, J=46261635300 | en_US |
dc.identifier.scopusauthorid | Yao, H=13104506400 | en_US |
dc.identifier.scopusauthorid | Kung, H=7402514190 | en_US |
dc.identifier.scopusauthorid | Li, D=24463373900 | en_US |
dc.identifier.issnl | 1932-6203 | - |