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Article: Heme oxygenase-1 system and gastrointestinal inflammation: A short review
Title | Heme oxygenase-1 system and gastrointestinal inflammation: A short review |
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Authors | |
Keywords | Gastrointestinal inflammation Heme oxygenase-1 |
Issue Date | 2011 |
Publisher | Baishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm |
Citation | World Journal Of Gastroenterology, 2011, v. 17 n. 38, p. 4283-4288 How to Cite? |
Abstract | Heme oxygenase-1 (HO-1) system catalyzes heme to biologically active products: carbon monoxide, biliverdin/ bilirubin and free iron. It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes. A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date. The ability to upregulate HO-1 byyypharmacological means or usinggene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future. © 2011 Baishideng. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/168585 |
ISSN | 2021 Impact Factor: 5.374 2020 SCImago Journal Rankings: 1.427 |
PubMed Central ID | |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhu, X | en_US |
dc.contributor.author | Fan, WG | en_US |
dc.contributor.author | Li, DP | en_US |
dc.contributor.author | Kung, H | en_US |
dc.contributor.author | Lin, MCM | en_US |
dc.date.accessioned | 2012-10-08T03:21:06Z | - |
dc.date.available | 2012-10-08T03:21:06Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | World Journal Of Gastroenterology, 2011, v. 17 n. 38, p. 4283-4288 | en_US |
dc.identifier.issn | 1007-9327 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/168585 | - |
dc.description.abstract | Heme oxygenase-1 (HO-1) system catalyzes heme to biologically active products: carbon monoxide, biliverdin/ bilirubin and free iron. It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes. A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date. The ability to upregulate HO-1 byyypharmacological means or usinggene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future. © 2011 Baishideng. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Baishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm | en_US |
dc.relation.ispartof | World Journal of Gastroenterology | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Gastrointestinal inflammation | - |
dc.subject | Heme oxygenase-1 | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bilirubin - Metabolism | en_US |
dc.subject.mesh | Biliverdine - Metabolism | en_US |
dc.subject.mesh | Gastrointestinal Tract - Enzymology - Pathology | en_US |
dc.subject.mesh | Heme Oxygenase-1 - Genetics - Metabolism | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Inflammation - Enzymology - Pathology | en_US |
dc.subject.mesh | Iron - Metabolism | en_US |
dc.subject.mesh | Isoenzymes - Genetics - Metabolism | en_US |
dc.subject.mesh | Nitric Oxide Synthase Type Ii - Metabolism | en_US |
dc.subject.mesh | Polymorphism, Genetic | en_US |
dc.subject.mesh | Promoter Regions, Genetic | en_US |
dc.subject.mesh | Up-Regulation | en_US |
dc.title | Heme oxygenase-1 system and gastrointestinal inflammation: A short review | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lin, MCM:mcllin@hkucc.hku.hk | en_US |
dc.identifier.authority | Lin, MCM=rp00746 | en_US |
dc.description.nature | published_or_final_version | en_US |
dc.identifier.doi | 10.3748/wjg.v17.i38.4283 | en_US |
dc.identifier.pmid | 22090784 | - |
dc.identifier.pmcid | PMC3214703 | - |
dc.identifier.scopus | eid_2-s2.0-80955151281 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-80955151281&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 38 | en_US |
dc.identifier.spage | 4283 | en_US |
dc.identifier.epage | 4288 | en_US |
dc.identifier.isi | WOS:000297220600005 | - |
dc.publisher.place | China | en_US |
dc.identifier.scopusauthorid | Zhu, X=34869035800 | en_US |
dc.identifier.scopusauthorid | Fan, WG=24070406000 | en_US |
dc.identifier.scopusauthorid | Li, DP=54412759300 | en_US |
dc.identifier.scopusauthorid | Kung, H=7402514190 | en_US |
dc.identifier.scopusauthorid | Lin, MCM=7404816359 | en_US |
dc.identifier.issnl | 1007-9327 | - |