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- Publisher Website: 10.1002/chem.201103025
- Scopus: eid_2-s2.0-84863481505
- PMID: 22693144
- WOS: WOS:000305942400024
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Article: New ruthenium(II) complexes functionalized with coumarin derivatives: Synthesis, energy-transfer-based sensing of esterase, cytotoxicity, and imaging studies
Title | New ruthenium(II) complexes functionalized with coumarin derivatives: Synthesis, energy-transfer-based sensing of esterase, cytotoxicity, and imaging studies |
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Authors | |
Keywords | Coumarins Energy Transfer Luminescence Ruthenium |
Issue Date | 2012 |
Publisher | Wiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/chemistry |
Citation | Chemistry - A European Journal, 2012, v. 18 n. 28, p. 8724-8730 How to Cite? |
Abstract | Two new bichromophoric ruthenium(II) complexes, [Ru(bpy) 2(bpy-CM)](PF 6) 2 and [Ru(bpy) 2(bpy-CM343)](PF 6) 2 (bpy=2,2'-bipyridine, CM=coumarin) with appended coumarin ligands have been designed and synthesized. The energy-transfer-based sensing of esterase by the complexes has been studied by using UV/Vis and luminescence spectroscopic methods. The cytotoxicity and the cellular uptake of one of the complexes have also been investigated. Woodruff-not only tasty! Two new bichromophoric ruthenium(II) complexes with appended coumarin ligands have been synthesized. The energy-transfer-based sensing of esterase by the complexes was studied by using UV/Vis and luminescence spectroscopy. The Ru II complex containing a coumarin 343 derivative was found to exhibit only a slight cytotoxicity towards HepG2 cells, and it was easily taken up in the living cells to show evident response to the esterase (see figure). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Persistent Identifier | http://hdl.handle.net/10722/168651 |
ISSN | 2023 Impact Factor: 3.9 2023 SCImago Journal Rankings: 1.058 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Li, MJ | en_US |
dc.contributor.author | Wong, KMC | en_US |
dc.contributor.author | Yi, C | en_US |
dc.contributor.author | Yam, VWW | en_US |
dc.date.accessioned | 2012-10-08T03:24:00Z | - |
dc.date.available | 2012-10-08T03:24:00Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Chemistry - A European Journal, 2012, v. 18 n. 28, p. 8724-8730 | en_US |
dc.identifier.issn | 0947-6539 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/168651 | - |
dc.description.abstract | Two new bichromophoric ruthenium(II) complexes, [Ru(bpy) 2(bpy-CM)](PF 6) 2 and [Ru(bpy) 2(bpy-CM343)](PF 6) 2 (bpy=2,2'-bipyridine, CM=coumarin) with appended coumarin ligands have been designed and synthesized. The energy-transfer-based sensing of esterase by the complexes has been studied by using UV/Vis and luminescence spectroscopic methods. The cytotoxicity and the cellular uptake of one of the complexes have also been investigated. Woodruff-not only tasty! Two new bichromophoric ruthenium(II) complexes with appended coumarin ligands have been synthesized. The energy-transfer-based sensing of esterase by the complexes was studied by using UV/Vis and luminescence spectroscopy. The Ru II complex containing a coumarin 343 derivative was found to exhibit only a slight cytotoxicity towards HepG2 cells, and it was easily taken up in the living cells to show evident response to the esterase (see figure). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | en_US |
dc.language | eng | en_US |
dc.publisher | Wiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/chemistry | en_US |
dc.relation.ispartof | Chemistry - A European Journal | en_US |
dc.subject | Coumarins | en_US |
dc.subject | Energy Transfer | en_US |
dc.subject | Luminescence | en_US |
dc.subject | Ruthenium | en_US |
dc.title | New ruthenium(II) complexes functionalized with coumarin derivatives: Synthesis, energy-transfer-based sensing of esterase, cytotoxicity, and imaging studies | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wong, KMC:wongmc@hku.hk | en_US |
dc.identifier.email | Yam, VWW:wwyam@hku.hk | en_US |
dc.identifier.authority | Wong, KMC=rp00809 | en_US |
dc.identifier.authority | Yam, VWW=rp00822 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/chem.201103025 | en_US |
dc.identifier.pmid | 22693144 | - |
dc.identifier.scopus | eid_2-s2.0-84863481505 | en_US |
dc.identifier.hkuros | 219074 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84863481505&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 18 | en_US |
dc.identifier.issue | 28 | en_US |
dc.identifier.spage | 8724 | en_US |
dc.identifier.epage | 8730 | en_US |
dc.identifier.isi | WOS:000305942400024 | - |
dc.publisher.place | Germany | en_US |
dc.identifier.scopusauthorid | Li, MJ=13105838700 | en_US |
dc.identifier.scopusauthorid | Wong, KMC=8061067200 | en_US |
dc.identifier.scopusauthorid | Yi, C=55260280300 | en_US |
dc.identifier.scopusauthorid | Yam, VWW=18539304700 | en_US |
dc.identifier.issnl | 0947-6539 | - |