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- Publisher Website: 10.1016/j.neurobiolaging.2012.06.018
- Scopus: eid_2-s2.0-84870501609
- PMID: 22840336
- WOS: WOS:000313117900006
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Article: Neural activities during affective processing in people with Alzheimer's disease
Title | Neural activities during affective processing in people with Alzheimer's disease |
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Authors | |
Keywords | Alzheimer's Disease Dementia Emotional Facial Expressions Mirror Neuron System |
Issue Date | 2013 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/neuaging |
Citation | Neurobiology Of Aging, 2013, v. 34 n. 3, p. 706-715 How to Cite? |
Abstract | This study examined brain activities in people with Alzheimer's disease when viewing happy, sad, and fearful facial expressions of others. A functional magnetic resonance imaging and a voxel-based morphometry methodology together with a passive viewing of emotional faces paradigm were employed to compare the affective processing in 12 people with mild Alzheimer's disease and 12 matched controls. The main finding was that the clinical participants showed reduced activations in regions associated with the motor simulation system (the ventral premotor cortex) and in regions associated with emotional simulation-empathy (the anterior insula and adjacent frontal operculum). This regional decline in blood oxygen level-dependent signals appeared to be lateralized in the left hemisphere and was not related to any structural degeneration in the clinical participants. Furthermore, the regions that showed changes in neural activity differed for the 3 emotional facial expressions studied. Findings of our study indicate that neural changes in regions associated with the motor and emotional simulation systems might play an important role in the development of Alzheimer's disease. © 2012 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/169109 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 1.488 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lee, TMC | en_US |
dc.contributor.author | Sun, D | en_US |
dc.contributor.author | Leung, MK | en_US |
dc.contributor.author | Chu, LW | en_US |
dc.contributor.author | Keysers, C | en_US |
dc.date.accessioned | 2012-10-08T03:41:54Z | - |
dc.date.available | 2012-10-08T03:41:54Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Neurobiology Of Aging, 2013, v. 34 n. 3, p. 706-715 | en_US |
dc.identifier.issn | 0197-4580 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/169109 | - |
dc.description.abstract | This study examined brain activities in people with Alzheimer's disease when viewing happy, sad, and fearful facial expressions of others. A functional magnetic resonance imaging and a voxel-based morphometry methodology together with a passive viewing of emotional faces paradigm were employed to compare the affective processing in 12 people with mild Alzheimer's disease and 12 matched controls. The main finding was that the clinical participants showed reduced activations in regions associated with the motor simulation system (the ventral premotor cortex) and in regions associated with emotional simulation-empathy (the anterior insula and adjacent frontal operculum). This regional decline in blood oxygen level-dependent signals appeared to be lateralized in the left hemisphere and was not related to any structural degeneration in the clinical participants. Furthermore, the regions that showed changes in neural activity differed for the 3 emotional facial expressions studied. Findings of our study indicate that neural changes in regions associated with the motor and emotional simulation systems might play an important role in the development of Alzheimer's disease. © 2012 Elsevier Inc. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/neuaging | en_US |
dc.relation.ispartof | Neurobiology of Aging | en_US |
dc.subject | Alzheimer's Disease | en_US |
dc.subject | Dementia | en_US |
dc.subject | Emotional Facial Expressions | en_US |
dc.subject | Mirror Neuron System | en_US |
dc.title | Neural activities during affective processing in people with Alzheimer's disease | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, TMC:tmclee@hku.hk | en_US |
dc.identifier.email | Sun, D:sundelin@hku.hk | en_US |
dc.identifier.authority | Lee, TMC=rp00564 | en_US |
dc.identifier.authority | Sun, D=rp00873 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.neurobiolaging.2012.06.018 | en_US |
dc.identifier.pmid | 22840336 | - |
dc.identifier.scopus | eid_2-s2.0-84870501609 | en_US |
dc.identifier.hkuros | 201607 | - |
dc.identifier.eissn | 1558-1497 | - |
dc.identifier.isi | WOS:000313117900006 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lee, TMC=7501437381 | en_US |
dc.identifier.scopusauthorid | Sun, D=25029722800 | en_US |
dc.identifier.scopusauthorid | Leung, MK=55318913500 | en_US |
dc.identifier.scopusauthorid | Chu, LW=55314710100 | en_US |
dc.identifier.scopusauthorid | Keysers, C=6603551269 | en_US |
dc.identifier.issnl | 0197-4580 | - |