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- Publisher Website: 10.1006/dbio.1998.8850
- Scopus: eid_2-s2.0-0032054895
- PMID: 9527877
- WOS: WOS:000073170500002
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Article: Local inhibitory action of BMPs and their relationships with activators in feather formation: Implications for periodic patterning
Title | Local inhibitory action of BMPs and their relationships with activators in feather formation: Implications for periodic patterning |
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Authors | |
Keywords | BMP Feather FGF Periodic pattern formation Reaction diffusion SHH Skin appendages |
Issue Date | 1998 |
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio |
Citation | Developmental Biology, 1998, v. 196 n. 1, p. 11-23 How to Cite? |
Abstract | The formation of periodic patterns is fundamental in biology. Theoretical models describing these phenomena have been proposed for feather patterning; however, no molecular candidates have been identified. Here we show that the feather tract is initiated by a continuous stripe of Shh, Fgf- 4, and Ptc expression in the epithelium, which then segregates into discrete feather primordia that are more strongly Shh and Fgf-4 positive. The primordia also become Bmp-2 and Bmp-4 positive. Bead-mediated delivery of BMPs inhibits local feather formation in contrast with the activators, SHH and FGF4, which induce feather formation. Both FGF-4 and SHH induce local expression of Bmp-4, while BMP-4 suppresses local expression of both. FGF-4 also induces Shh. Based on these findings, we propose a model that involves (1) homogeneously distributed global activators that define the field, (2) a position-dependent activator of competence that propagates across the field, and (3) local activators and inhibitors triggered in sites of individual primordia that act in a reaction-diffusion mechanism. A computer simulation model for feather pattern formation is also presented. |
Persistent Identifier | http://hdl.handle.net/10722/169528 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 1.147 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, HS | en_US |
dc.contributor.author | FrancisWest, PH | en_US |
dc.contributor.author | Widelitz, RB | en_US |
dc.contributor.author | Jiang, TX | en_US |
dc.contributor.author | TingBerreth, S | en_US |
dc.contributor.author | Tickle, C | en_US |
dc.contributor.author | Wolpert, L | en_US |
dc.contributor.author | Chuong, CM | en_US |
dc.date.accessioned | 2012-10-25T04:52:34Z | - |
dc.date.available | 2012-10-25T04:52:34Z | - |
dc.date.issued | 1998 | en_US |
dc.identifier.citation | Developmental Biology, 1998, v. 196 n. 1, p. 11-23 | en_US |
dc.identifier.issn | 0012-1606 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/169528 | - |
dc.description.abstract | The formation of periodic patterns is fundamental in biology. Theoretical models describing these phenomena have been proposed for feather patterning; however, no molecular candidates have been identified. Here we show that the feather tract is initiated by a continuous stripe of Shh, Fgf- 4, and Ptc expression in the epithelium, which then segregates into discrete feather primordia that are more strongly Shh and Fgf-4 positive. The primordia also become Bmp-2 and Bmp-4 positive. Bead-mediated delivery of BMPs inhibits local feather formation in contrast with the activators, SHH and FGF4, which induce feather formation. Both FGF-4 and SHH induce local expression of Bmp-4, while BMP-4 suppresses local expression of both. FGF-4 also induces Shh. Based on these findings, we propose a model that involves (1) homogeneously distributed global activators that define the field, (2) a position-dependent activator of competence that propagates across the field, and (3) local activators and inhibitors triggered in sites of individual primordia that act in a reaction-diffusion mechanism. A computer simulation model for feather pattern formation is also presented. | en_US |
dc.language | eng | en_US |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio | en_US |
dc.relation.ispartof | Developmental Biology | en_US |
dc.subject | BMP | - |
dc.subject | Feather | - |
dc.subject | FGF | - |
dc.subject | Periodic pattern formation | - |
dc.subject | Reaction diffusion | - |
dc.subject | SHH | - |
dc.subject | Skin appendages | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Body Patterning | en_US |
dc.subject.mesh | Bone Morphogenetic Protein 2 | en_US |
dc.subject.mesh | Bone Morphogenetic Protein 4 | en_US |
dc.subject.mesh | Bone Morphogenetic Proteins - Pharmacology | en_US |
dc.subject.mesh | Chick Embryo | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Factor Ix - Metabolism | en_US |
dc.subject.mesh | Feathers - Embryology | en_US |
dc.subject.mesh | Fibroblast Growth Factor 4 | en_US |
dc.subject.mesh | Fibroblast Growth Factors - Metabolism | en_US |
dc.subject.mesh | Gene Expression Regulation, Developmental | en_US |
dc.subject.mesh | Hedgehog Proteins | en_US |
dc.subject.mesh | Models, Biological | en_US |
dc.subject.mesh | Periodicity | en_US |
dc.subject.mesh | Proteins - Metabolism | en_US |
dc.subject.mesh | Proto-Oncogene Proteins - Metabolism | en_US |
dc.subject.mesh | Skin - Embryology | en_US |
dc.subject.mesh | Tissue Distribution | en_US |
dc.subject.mesh | Trans-Activators | en_US |
dc.subject.mesh | Transforming Growth Factor Beta | en_US |
dc.title | Local inhibitory action of BMPs and their relationships with activators in feather formation: Implications for periodic patterning | en_US |
dc.type | Article | en_US |
dc.identifier.email | Jung, HS: hsjung@yuhs.ac | en_US |
dc.identifier.authority | Jung, HS=rp01683 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1006/dbio.1998.8850 | en_US |
dc.identifier.pmid | 9527877 | en_US |
dc.identifier.scopus | eid_2-s2.0-0032054895 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0032054895&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 196 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 11 | en_US |
dc.identifier.epage | 23 | en_US |
dc.identifier.isi | WOS:000073170500002 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Jung, HS=7403030195 | en_US |
dc.identifier.scopusauthorid | FrancisWest, PH=7003730165 | en_US |
dc.identifier.scopusauthorid | Widelitz, RB=6701556360 | en_US |
dc.identifier.scopusauthorid | Jiang, TX=7402148591 | en_US |
dc.identifier.scopusauthorid | TingBerreth, S=6506000954 | en_US |
dc.identifier.scopusauthorid | Tickle, C=7005294923 | en_US |
dc.identifier.scopusauthorid | Wolpert, L=7005114065 | en_US |
dc.identifier.scopusauthorid | Chuong, CM=7103159962 | en_US |
dc.identifier.issnl | 0012-1606 | - |