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- Publisher Website: 10.1080/02713680902843047
- Scopus: eid_2-s2.0-67649649885
- PMID: 19401879
- WOS: WOS:000265581500005
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Article: Characteristics of ethylnitrosourea-induced cataracts
Title | Characteristics of ethylnitrosourea-induced cataracts |
---|---|
Authors | |
Keywords | Cataract Crystallins ENU (ethylnitrosourea) Gap junction Zonular-pulverulent cataract type |
Issue Date | 2009 |
Publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/02713683.asp |
Citation | Current Eye Research, 2009, v. 34 n. 5, p. 360-368 How to Cite? |
Abstract | Purpose: This study analyzed genes associated with the morphology and regulation of ethylnitrosourea (ENU)-induced cataract mouse. Materials and Methods: Immunohistochemistry analysis using anti-crystallins and PCNA antibody revealed that the localization pattern of these specific markers differed between the cataractous and wild-type lens epithelium. Two-dimensional electrophoresis and microarray techniques were used to identify the proteins and genes related to ENU-induced cataract. Results: A novel ENU-induced mutation in the mouse led to nuclear and cortical opacity of the eye lens at 5 weeks postnatal. This cataract phenotype was similar to that of the zonular-pulverulent type of human cataract. Crystallin proteins and gap-junction genes have relations to the formation of cataract. Conclusions: Together, the results suggest that various proteins affect the formation and specific phenotypes of ENU-induced cataract mouse. |
Persistent Identifier | http://hdl.handle.net/10722/169560 |
ISSN | 2023 Impact Factor: 1.7 2023 SCImago Journal Rankings: 0.741 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, MJ | en_US |
dc.contributor.author | Kim, JY | en_US |
dc.contributor.author | Kim, YJ | en_US |
dc.contributor.author | Cho, JW | en_US |
dc.contributor.author | Cho, KH | en_US |
dc.contributor.author | Song, CW | en_US |
dc.contributor.author | Jung, HS | en_US |
dc.date.accessioned | 2012-10-25T04:52:52Z | - |
dc.date.available | 2012-10-25T04:52:52Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Current Eye Research, 2009, v. 34 n. 5, p. 360-368 | en_US |
dc.identifier.issn | 0271-3683 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/169560 | - |
dc.description.abstract | Purpose: This study analyzed genes associated with the morphology and regulation of ethylnitrosourea (ENU)-induced cataract mouse. Materials and Methods: Immunohistochemistry analysis using anti-crystallins and PCNA antibody revealed that the localization pattern of these specific markers differed between the cataractous and wild-type lens epithelium. Two-dimensional electrophoresis and microarray techniques were used to identify the proteins and genes related to ENU-induced cataract. Results: A novel ENU-induced mutation in the mouse led to nuclear and cortical opacity of the eye lens at 5 weeks postnatal. This cataract phenotype was similar to that of the zonular-pulverulent type of human cataract. Crystallin proteins and gap-junction genes have relations to the formation of cataract. Conclusions: Together, the results suggest that various proteins affect the formation and specific phenotypes of ENU-induced cataract mouse. | en_US |
dc.language | eng | en_US |
dc.publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/02713683.asp | en_US |
dc.relation.ispartof | Current Eye Research | en_US |
dc.subject | Cataract | - |
dc.subject | Crystallins | - |
dc.subject | ENU (ethylnitrosourea) | - |
dc.subject | Gap junction | - |
dc.subject | Zonular-pulverulent cataract type | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cataract - Chemically Induced - Genetics - Metabolism - Pathology | en_US |
dc.subject.mesh | Connexins - Genetics | en_US |
dc.subject.mesh | Crystallins - Genetics - Metabolism | en_US |
dc.subject.mesh | Dna Mutational Analysis | en_US |
dc.subject.mesh | Electrophoresis, Gel, Two-Dimensional | en_US |
dc.subject.mesh | Ethylnitrosourea | en_US |
dc.subject.mesh | Eye Proteins - Genetics | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Mice, Inbred Balb C | en_US |
dc.subject.mesh | Phenotype | en_US |
dc.subject.mesh | Proliferating Cell Nuclear Antigen - Metabolism | en_US |
dc.subject.mesh | Protein Array Analysis | en_US |
dc.subject.mesh | Tissue Distribution | en_US |
dc.title | Characteristics of ethylnitrosourea-induced cataracts | en_US |
dc.type | Article | en_US |
dc.identifier.email | Jung, HS: hsjung@yuhs.ac | en_US |
dc.identifier.authority | Jung, HS=rp01683 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1080/02713680902843047 | en_US |
dc.identifier.pmid | 19401879 | en_US |
dc.identifier.scopus | eid_2-s2.0-67649649885 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-67649649885&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 34 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 360 | en_US |
dc.identifier.epage | 368 | en_US |
dc.identifier.isi | WOS:000265581500005 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Lee, MJ=35264472100 | en_US |
dc.identifier.scopusauthorid | Kim, JY=7601361822 | en_US |
dc.identifier.scopusauthorid | Kim, YJ=16833275700 | en_US |
dc.identifier.scopusauthorid | Cho, JW=34869479800 | en_US |
dc.identifier.scopusauthorid | Cho, KH=8450197800 | en_US |
dc.identifier.scopusauthorid | Song, CW=7403253231 | en_US |
dc.identifier.scopusauthorid | Jung, HS=7403030195 | en_US |
dc.identifier.issnl | 0271-3683 | - |