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Article: Interference with the formation of the epididymal microenvironment - A new strategy for male contraception ?
Title | Interference with the formation of the epididymal microenvironment - A new strategy for male contraception ? |
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Authors | |
Keywords | Contraception Cyclooxygenase Cystic Fibrosis Transmembrane Conductance Regulator Epididymis |
Issue Date | 2000 |
Publisher | Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1008-682X&site=1 |
Citation | Asian Journal Of Andrology, 2000, v. 2 n. 1, p. 39-45 How to Cite? |
Abstract | The cystic fibrosis transmembrane conductance regulator (CFTR) or the small conductance cAMP-activated chloride channel encoded by the CFTR gene has been shown to play an important role in the formation of the epididymal fluid microenvironment. Recent work in our laboratory has shown that this protein is also expressed by developing germ cells indicating a role of this protein in spermatogenesis. In view of the fact that the CFTR gene has a far reaching and widespread effect on human reproduction, understanding the role of CFTR in the male reproductive tissues and its intervention by pharmacological agents can open a new avenue of research into the development of novel male contraceptives. © 2000, Asian Journal of Andrology. |
Persistent Identifier | http://hdl.handle.net/10722/169743 |
ISSN | 2023 Impact Factor: 3.0 2023 SCImago Journal Rankings: 0.689 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gong, XD | en_US |
dc.contributor.author | Leung, GPH | en_US |
dc.contributor.author | Cheuk, BLY | en_US |
dc.contributor.author | Wong, PYD | en_US |
dc.date.accessioned | 2012-10-25T04:54:48Z | - |
dc.date.available | 2012-10-25T04:54:48Z | - |
dc.date.issued | 2000 | en_US |
dc.identifier.citation | Asian Journal Of Andrology, 2000, v. 2 n. 1, p. 39-45 | en_US |
dc.identifier.issn | 1008-682X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/169743 | - |
dc.description.abstract | The cystic fibrosis transmembrane conductance regulator (CFTR) or the small conductance cAMP-activated chloride channel encoded by the CFTR gene has been shown to play an important role in the formation of the epididymal fluid microenvironment. Recent work in our laboratory has shown that this protein is also expressed by developing germ cells indicating a role of this protein in spermatogenesis. In view of the fact that the CFTR gene has a far reaching and widespread effect on human reproduction, understanding the role of CFTR in the male reproductive tissues and its intervention by pharmacological agents can open a new avenue of research into the development of novel male contraceptives. © 2000, Asian Journal of Andrology. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1008-682X&site=1 | en_US |
dc.relation.ispartof | Asian Journal of Andrology | en_US |
dc.subject | Contraception | en_US |
dc.subject | Cyclooxygenase | en_US |
dc.subject | Cystic Fibrosis Transmembrane Conductance Regulator | en_US |
dc.subject | Epididymis | en_US |
dc.title | Interference with the formation of the epididymal microenvironment - A new strategy for male contraception ? | en_US |
dc.type | Article | en_US |
dc.identifier.email | Leung, GPH: gphleung@hkucc.hku.hk | en_US |
dc.identifier.email | Cheuk, BLY: bernice@hku.hk | en_US |
dc.identifier.authority | Leung, GPH=rp00234 | en_US |
dc.identifier.authority | Cheuk, BLY=rp01671 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.scopus | eid_2-s2.0-0034158038 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0034158038&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 2 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 39 | en_US |
dc.identifier.epage | 45 | en_US |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Gong, XD=7201999007 | en_US |
dc.identifier.scopusauthorid | Leung, GPH=35963668200 | en_US |
dc.identifier.scopusauthorid | Cheuk, BLY=7801343617 | en_US |
dc.identifier.scopusauthorid | Wong, PYD=7403980262 | en_US |
dc.identifier.issnl | 1008-682X | - |