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Article: μ opioid receptor knockout in mice: Effects on ligand-induced analgesia and morphine lethality

Titleμ opioid receptor knockout in mice: Effects on ligand-induced analgesia and morphine lethality
Authors
Loh, HHLiu, HCCavalli, AYang, WChen, YFWei, LN
Keywordsμ opioid receptor
Gene-targeting
Morphine analgesia
Morphine lethality
Issue Date1998
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/molbrainres
Citation
Molecular Brain Research, 1998, v. 54 n. 2, p. 321-326 How to Cite?
DOI: http://dx.doi.org/10.1016/S0169-328X(97)00353-7
AbstractThe μ opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure. In these MOR-knockout mice, the analgesic effects of morphine, its major metabolites, morphine-6-glucuronide (M-6-G) and morphine-6-ethereal sulfate (M-6-S), and endomorphin-2, as well as morphine-induced lethality, were drastically reduced, whereas the effects of DPDPE and U50488 remained unchanged. It is concluded that analgesic effects of μ-specific opioid ligands and acute morphine lethality are mediated by the μ receptor.
Persistent Identifierhttp://hdl.handle.net/10722/170291
ISSN
0169-328X
ISI Accession Number ID
WOS:000073218100015
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLoh, HHen_US
dc.contributor.authorLiu, HCen_US
dc.contributor.authorCavalli, Aen_US
dc.contributor.authorYang, Wen_US
dc.contributor.authorChen, YFen_US
dc.contributor.authorWei, LNen_US
dc.date.accessioned2012-10-30T06:07:16Z-
dc.date.available2012-10-30T06:07:16Z-
dc.date.issued1998en_US
dc.identifier.citationMolecular Brain Research, 1998, v. 54 n. 2, p. 321-326en_US
dc.identifier.issn0169-328Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/170291-
dc.description.abstractThe μ opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure. In these MOR-knockout mice, the analgesic effects of morphine, its major metabolites, morphine-6-glucuronide (M-6-G) and morphine-6-ethereal sulfate (M-6-S), and endomorphin-2, as well as morphine-induced lethality, were drastically reduced, whereas the effects of DPDPE and U50488 remained unchanged. It is concluded that analgesic effects of μ-specific opioid ligands and acute morphine lethality are mediated by the μ receptor.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/molbrainresen_US
dc.relation.ispartofMolecular Brain Researchen_US
dc.subjectμ opioid receptor-
dc.subjectGene-targeting-
dc.subjectMorphine analgesia-
dc.subjectMorphine lethality-
dc.subject.meshAnalgesics, Opioid - Toxicityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshGenotypeen_US
dc.subject.meshLethal Dose 50en_US
dc.subject.meshLigandsen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Knockouten_US
dc.subject.meshMorphine - Toxicityen_US
dc.subject.meshMorphine Derivatives - Toxicityen_US
dc.subject.meshOligopeptides - Toxicityen_US
dc.subject.meshReceptors, Opioid, Mu - Geneticsen_US
dc.titleμ opioid receptor knockout in mice: Effects on ligand-induced analgesia and morphine lethalityen_US
dc.typeArticleen_US
dc.identifier.emailYang, W:yangwl@hkucc.hku.hken_US
dc.identifier.authorityYang, W=rp00524en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0169-328X(97)00353-7en_US
dc.identifier.pmid9555078-
dc.identifier.scopuseid_2-s2.0-0032031040en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032031040&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume54en_US
dc.identifier.issue2en_US
dc.identifier.spage321en_US
dc.identifier.epage326en_US
dc.identifier.isiWOS:000073218100015-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLoh, HH=35497433400en_US
dc.identifier.scopusauthoridLiu, HC=7409748390en_US
dc.identifier.scopusauthoridCavalli, A=7101898409en_US
dc.identifier.scopusauthoridYang, W=23101349500en_US
dc.identifier.scopusauthoridChen, YF=8223792100en_US
dc.identifier.scopusauthoridWei, LN=7402950741en_US
dc.identifier.issnl0169-328X-

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