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- Publisher Website: 10.1016/j.ijcard.2006.10.024
- Scopus: eid_2-s2.0-34548474310
- PMID: 17182138
- WOS: WOS:000250558400003
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Article: Plasma brain natriuretic peptide levels, right ventricular volume overload and exercise capacity in adolescents after surgical repair of tetralogy of Fallot
Title | Plasma brain natriuretic peptide levels, right ventricular volume overload and exercise capacity in adolescents after surgical repair of tetralogy of Fallot |
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Authors | |
Keywords | Brain natriuretic peptide Exercise capacity Right ventricle Tetralogy of Fallot |
Issue Date | 2007 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard |
Citation | International Journal Of Cardiology, 2007, v. 121 n. 2, p. 155-162 How to Cite? |
Abstract | Background: Right ventricular (RV) volume overload secondary to pulmonary regurgitation contributes to long-term morbidities in patients after tetralogy of Fallot (TOF) repair. We tested the hypothesis that plasma brain natriuretic peptide (BNP) levels relate to RV volume overload, pulmonary regurgitation, and exercise capacity in adolescents after TOF repair. Methods: We assessed the RV function echocardiographically and plasma BNP levels in 32 postoperative TOF patients aged 14.7 ± 3.1 years and 20 age-matched controls. Eighteen patients further underwent cardiovascular magnetic resonance imaging and 26 had exercise testing. Results: Compared with controls, patients had significantly higher BNP levels (p = 0.027), greater indexed RV end-diastolic dimension (p < 0.001), increased RV myocardial performance index (p = 0.005), and reduced tricuspid annular systolic velocity (p = 0.008). Multivariate analysis identified indexed RV end-diastolic dimension as the only significant determinant of plasma BNP levels (β = 0.69, p < 0.001). Plasma BNP levels correlated positively with indexed RV end-diastolic volume (r = 0.6, p = 0.009) and pulmonary regurgitant fraction (r = 0.54, p = 0.026), and negatively with exercise duration (r = - 0.45, p = 0.021), peak oxygen consumption (r = - 0.43, p = 0.03), and minute ventilation at maximal exercise (r = - 0.52, p = 0.006). Multivariate analysis demonstrated BNP levels (β = - 0.43, p = 0.034) and body mass index (β = - 0.40, p = 0.036) to be independent predictors of peak oxygen consumption. No relations were found between BNP levels and RV myocardial performance index, tricuspid annular velocities and RV ejection fraction. Conclusions: In adolescent patients after TOF repair, plasma BNP levels relate to RV volume overload, pulmonary regurgitation and exercise capacity. © 2006 Elsevier Ireland Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/170388 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 1.126 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Cheung, EWY | en_US |
dc.contributor.author | Lam, WWM | en_US |
dc.contributor.author | Chiu, CSW | en_US |
dc.contributor.author | Chau, AKT | en_US |
dc.contributor.author | Cheung, SCW | en_US |
dc.contributor.author | Cheung, Yf | en_US |
dc.date.accessioned | 2012-10-30T06:07:57Z | - |
dc.date.available | 2012-10-30T06:07:57Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | International Journal Of Cardiology, 2007, v. 121 n. 2, p. 155-162 | en_US |
dc.identifier.issn | 0167-5273 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170388 | - |
dc.description.abstract | Background: Right ventricular (RV) volume overload secondary to pulmonary regurgitation contributes to long-term morbidities in patients after tetralogy of Fallot (TOF) repair. We tested the hypothesis that plasma brain natriuretic peptide (BNP) levels relate to RV volume overload, pulmonary regurgitation, and exercise capacity in adolescents after TOF repair. Methods: We assessed the RV function echocardiographically and plasma BNP levels in 32 postoperative TOF patients aged 14.7 ± 3.1 years and 20 age-matched controls. Eighteen patients further underwent cardiovascular magnetic resonance imaging and 26 had exercise testing. Results: Compared with controls, patients had significantly higher BNP levels (p = 0.027), greater indexed RV end-diastolic dimension (p < 0.001), increased RV myocardial performance index (p = 0.005), and reduced tricuspid annular systolic velocity (p = 0.008). Multivariate analysis identified indexed RV end-diastolic dimension as the only significant determinant of plasma BNP levels (β = 0.69, p < 0.001). Plasma BNP levels correlated positively with indexed RV end-diastolic volume (r = 0.6, p = 0.009) and pulmonary regurgitant fraction (r = 0.54, p = 0.026), and negatively with exercise duration (r = - 0.45, p = 0.021), peak oxygen consumption (r = - 0.43, p = 0.03), and minute ventilation at maximal exercise (r = - 0.52, p = 0.006). Multivariate analysis demonstrated BNP levels (β = - 0.43, p = 0.034) and body mass index (β = - 0.40, p = 0.036) to be independent predictors of peak oxygen consumption. No relations were found between BNP levels and RV myocardial performance index, tricuspid annular velocities and RV ejection fraction. Conclusions: In adolescent patients after TOF repair, plasma BNP levels relate to RV volume overload, pulmonary regurgitation and exercise capacity. © 2006 Elsevier Ireland Ltd. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard | en_US |
dc.relation.ispartof | International Journal of Cardiology | en_US |
dc.subject | Brain natriuretic peptide | - |
dc.subject | Exercise capacity | - |
dc.subject | Right ventricle | - |
dc.subject | Tetralogy of Fallot | - |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Child | en_US |
dc.subject.mesh | Cohort Studies | en_US |
dc.subject.mesh | Exercise Test - Methods | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Natriuretic Peptide, Brain - Blood | en_US |
dc.subject.mesh | Tetralogy Of Fallot - Blood - Physiopathology - Surgery | en_US |
dc.subject.mesh | Ventricular Dysfunction, Right - Blood - Physiopathology - Surgery | en_US |
dc.subject.mesh | Ventricular Function, Right - Physiology | en_US |
dc.title | Plasma brain natriuretic peptide levels, right ventricular volume overload and exercise capacity in adolescents after surgical repair of tetralogy of Fallot | en_US |
dc.type | Article | en_US |
dc.identifier.email | Cheung, Yf:xfcheung@hku.hk | en_US |
dc.identifier.authority | Cheung, Yf=rp00382 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.ijcard.2006.10.024 | en_US |
dc.identifier.pmid | 17182138 | - |
dc.identifier.scopus | eid_2-s2.0-34548474310 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-34548474310&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 121 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 155 | en_US |
dc.identifier.epage | 162 | en_US |
dc.identifier.isi | WOS:000250558400003 | - |
dc.publisher.place | Ireland | en_US |
dc.identifier.scopusauthorid | Cheung, EWY=9432819700 | en_US |
dc.identifier.scopusauthorid | Lam, WWM=35292558200 | en_US |
dc.identifier.scopusauthorid | Chiu, CSW=8714554800 | en_US |
dc.identifier.scopusauthorid | Chau, AKT=35787094400 | en_US |
dc.identifier.scopusauthorid | Cheung, SCW=17533628600 | en_US |
dc.identifier.scopusauthorid | Cheung, Yf=7202111067 | en_US |
dc.identifier.issnl | 0167-5273 | - |