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Article: Challenges in the management of juvenile myelomonocytic leukaemia in Hong Kong over the past two decades
Title | Challenges in the management of juvenile myelomonocytic leukaemia in Hong Kong over the past two decades |
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Authors | |
Keywords | Case Series Diagnosis Juvenile Myelomonocytic Leukaemia Treatment Outcome |
Issue Date | 2012 |
Publisher | Medcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp |
Citation | Hong Kong Journal Of Paediatrics, 2012, v. 17 n. 3, p. 148-155 How to Cite? |
Abstract | Juvenile myelomonocytic leukaemia (JMML) is a rare myeloid malignancy of childhood. The diagnosis and treatment of this disease still remain as major clinical challenges. We aim to describe the clinical and pathological findings, as well as treatment outcomes of eight patients with JMML who received treatment in two hospitals in Hong Kong between 1993 and 2011. One patient with Noonan syndrome showed spontaneous resolution of disease. Four patients underwent allogeneic haematopoietic stem cell transplantation during 1996 to 2007. Three of them died of post-transplant relapse and refractory disease or transplant-related toxicity. The surviving transplanted patient had chronic graft-versus-host disease for 4 years, and eventually showed evidence of disease relapse with documented mixed chimerism. The other three patients who received supportive treatment were alive with persistent disease. Our future works should focus on optimising therapy and improving treatment outcome for JMML patients. |
Persistent Identifier | http://hdl.handle.net/10722/170470 |
ISSN | 2023 Impact Factor: 0.1 2023 SCImago Journal Rankings: 0.117 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Surapolchai, P | en_US |
dc.contributor.author | Ha, SY | en_US |
dc.contributor.author | Chiang, AKS | en_US |
dc.contributor.author | Cheuk, DKL | en_US |
dc.contributor.author | Li, CH | en_US |
dc.contributor.author | So, CC | en_US |
dc.contributor.author | Wan, TSK | en_US |
dc.contributor.author | Chan, GCF | en_US |
dc.date.accessioned | 2012-10-30T06:09:14Z | - |
dc.date.available | 2012-10-30T06:09:14Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Hong Kong Journal Of Paediatrics, 2012, v. 17 n. 3, p. 148-155 | en_US |
dc.identifier.issn | 1013-9923 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170470 | - |
dc.description.abstract | Juvenile myelomonocytic leukaemia (JMML) is a rare myeloid malignancy of childhood. The diagnosis and treatment of this disease still remain as major clinical challenges. We aim to describe the clinical and pathological findings, as well as treatment outcomes of eight patients with JMML who received treatment in two hospitals in Hong Kong between 1993 and 2011. One patient with Noonan syndrome showed spontaneous resolution of disease. Four patients underwent allogeneic haematopoietic stem cell transplantation during 1996 to 2007. Three of them died of post-transplant relapse and refractory disease or transplant-related toxicity. The surviving transplanted patient had chronic graft-versus-host disease for 4 years, and eventually showed evidence of disease relapse with documented mixed chimerism. The other three patients who received supportive treatment were alive with persistent disease. Our future works should focus on optimising therapy and improving treatment outcome for JMML patients. | en_US |
dc.language | eng | en_US |
dc.publisher | Medcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp | en_US |
dc.relation.ispartof | Hong Kong Journal of Paediatrics | en_US |
dc.subject | Case Series | en_US |
dc.subject | Diagnosis | en_US |
dc.subject | Juvenile Myelomonocytic Leukaemia | en_US |
dc.subject | Treatment Outcome | en_US |
dc.title | Challenges in the management of juvenile myelomonocytic leukaemia in Hong Kong over the past two decades | en_US |
dc.type | Article | en_US |
dc.identifier.email | Chiang, AKS:chiangak@hkucc.hku.hk | en_US |
dc.identifier.email | Chan, GCF:gcfchan@hkucc.hku.hk | en_US |
dc.identifier.authority | Chiang, AKS=rp00403 | en_US |
dc.identifier.authority | Chan, GCF=rp00431 | en_US |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.scopus | eid_2-s2.0-84864392566 | en_US |
dc.identifier.hkuros | 209851 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84864392566&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 148 | en_US |
dc.identifier.epage | 155 | en_US |
dc.publisher.place | Hong Kong | en_US |
dc.identifier.scopusauthorid | Surapolchai, P=36027047200 | en_US |
dc.identifier.scopusauthorid | Ha, SY=7202501115 | en_US |
dc.identifier.scopusauthorid | Chiang, AKS=7101623534 | en_US |
dc.identifier.scopusauthorid | Cheuk, DKL=8705936100 | en_US |
dc.identifier.scopusauthorid | Li, CH=8354475100 | en_US |
dc.identifier.scopusauthorid | So, CC=55323432800 | en_US |
dc.identifier.scopusauthorid | Wan, TSK=55323335300 | en_US |
dc.identifier.scopusauthorid | Chan, GCF=16160154400 | en_US |
dc.identifier.issnl | 1013-9923 | - |