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Article: Effect of BL-5111-A, prazosin and phentolamine on responses of canine cutaneous veins to adrenergic activation

TitleEffect of BL-5111-A, prazosin and phentolamine on responses of canine cutaneous veins to adrenergic activation
Authors
Rusch, NJDe Mey, JGVanhoutte, PM
Issue Date1980
Citation
Archives Internationales De Pharmacodynamie Et De Therapie, 1980, v. 244 n. 2, p. 341-343 How to Cite?
AbstractBL-5111-A, 4-amino-6,7-dimethoxy-2-[4-(5-methylthio-1,3,4-oxadiazole-2-carbonyl)-piperazin-1-yl] quinazoline hydrochloride, is a novel alpha-adrenolytic drug with antihypertensive properties in the intact animal. In the present study, the alpha-adrenolytic properties of BL-5111-A were compared with those of phentolamine and prazosin, using cutaneous veins of the dog as a model of adrenergically innervated vascular smooth muscle.
Persistent Identifierhttp://hdl.handle.net/10722/170620
ISSN
0003-9780
ISI Accession Number ID
WOS:A1980JY74700021

 

DC FieldValueLanguage
dc.contributor.authorRusch, NJen_US
dc.contributor.authorDe Mey, JGen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:10Z-
dc.date.available2012-10-30T06:10:10Z-
dc.date.issued1980en_US
dc.identifier.citationArchives Internationales De Pharmacodynamie Et De Therapie, 1980, v. 244 n. 2, p. 341-343en_US
dc.identifier.issn0003-9780en_US
dc.identifier.urihttp://hdl.handle.net/10722/170620-
dc.description.abstractBL-5111-A, 4-amino-6,7-dimethoxy-2-[4-(5-methylthio-1,3,4-oxadiazole-2-carbonyl)-piperazin-1-yl] quinazoline hydrochloride, is a novel alpha-adrenolytic drug with antihypertensive properties in the intact animal. In the present study, the alpha-adrenolytic properties of BL-5111-A were compared with those of phentolamine and prazosin, using cutaneous veins of the dog as a model of adrenergically innervated vascular smooth muscle.en_US
dc.languageengen_US
dc.relation.ispartofArchives Internationales de Pharmacodynamie et de Therapieen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCocaine - Antagonists & Inhibitorsen_US
dc.subject.meshDogsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Antagonismen_US
dc.subject.meshEstradiolen_US
dc.subject.meshEstradiol Antagonistsen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiologyen_US
dc.subject.meshNorepinephrine - Antagonists & Inhibitorsen_US
dc.subject.meshPhentolamine - Pharmacologyen_US
dc.subject.meshPrazosin - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshPropranolol - Antagonists & Inhibitorsen_US
dc.subject.meshQuinazolines - Pharmacologyen_US
dc.subject.meshSaphenous Vein - Physiologyen_US
dc.subject.meshSympathomimetics - Antagonists & Inhibitorsen_US
dc.titleEffect of BL-5111-A, prazosin and phentolamine on responses of canine cutaneous veins to adrenergic activationen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7406593-
dc.identifier.scopuseid_2-s2.0-0019224285en_US
dc.identifier.volume244en_US
dc.identifier.issue2en_US
dc.identifier.spage341en_US
dc.identifier.epage343en_US
dc.identifier.isiWOS:A1980JY74700021-
dc.identifier.scopusauthoridRusch, NJ=7005728816en_US
dc.identifier.scopusauthoridDe Mey, JG=7101918486en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.issnl0003-9780-

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