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- Publisher Website: 10.1161/01.CIR.64.4.655
- Scopus: eid_2-s2.0-0019442014
- PMID: 6268334
- WOS: WOS:A1981MH62300001
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Article: Local modulation of adrenergic neurotransmission
Title | Local modulation of adrenergic neurotransmission |
---|---|
Authors | |
Issue Date | 1981 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org |
Citation | Circulation, 1981, v. 64 n. 4, p. 655-666 How to Cite? |
Abstract | The cardiovascular reflexes, by regulating the traffic in the sympathetic nerves, govern the amount of norepinephrine released from the nerve endings. However, the final adjustment in the amount of neurotransmitter available to activate the β1 receptors in the heart and the α receptors in the blood vessels takes place at the sympathetic neuroeffector junction. Thus, a decrease in pH, hyperosmolarity, moderate increases in the concentration of K+ ion, adenosine and adenine nucleotides depress the release of norepinephrine at any given level of sympathetic nerve activity. These metabolic changes, which occur in active tissues, and in particular in adenosine, have been proposed as mediators of the accompanying local hyperemia. In addition, they apparently facilitate this local dilation by disconnecting the blood vessels in the active tissues from sympathetic control. Acetylcholine, histamine and 5-hydroxytryptamine are present in and around certain blood vessels and can activate specific receptors on the prejunctional fibers and cause vasodilation by reducing the output of neurotransmitter. Some of the norepinephrine released into the synaptic cleft may depress its continued release by activating prejunctional α receptors. In contrast, angiotensin II, by a local action on the nerve endings, can augment the release of transmitter. Decreases in local temperature reduce transmitter release but augment the affinity of the postjunctional α receptors for norepinephrine. The role of these local events at the neuroeffector junction, their physiologic significance and potential clinical importance are discussed in this review. |
Persistent Identifier | http://hdl.handle.net/10722/170635 |
ISSN | 2023 Impact Factor: 35.5 2023 SCImago Journal Rankings: 8.415 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shepherd, JT | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:10:14Z | - |
dc.date.available | 2012-10-30T06:10:14Z | - |
dc.date.issued | 1981 | en_US |
dc.identifier.citation | Circulation, 1981, v. 64 n. 4, p. 655-666 | en_US |
dc.identifier.issn | 0009-7322 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170635 | - |
dc.description.abstract | The cardiovascular reflexes, by regulating the traffic in the sympathetic nerves, govern the amount of norepinephrine released from the nerve endings. However, the final adjustment in the amount of neurotransmitter available to activate the β1 receptors in the heart and the α receptors in the blood vessels takes place at the sympathetic neuroeffector junction. Thus, a decrease in pH, hyperosmolarity, moderate increases in the concentration of K+ ion, adenosine and adenine nucleotides depress the release of norepinephrine at any given level of sympathetic nerve activity. These metabolic changes, which occur in active tissues, and in particular in adenosine, have been proposed as mediators of the accompanying local hyperemia. In addition, they apparently facilitate this local dilation by disconnecting the blood vessels in the active tissues from sympathetic control. Acetylcholine, histamine and 5-hydroxytryptamine are present in and around certain blood vessels and can activate specific receptors on the prejunctional fibers and cause vasodilation by reducing the output of neurotransmitter. Some of the norepinephrine released into the synaptic cleft may depress its continued release by activating prejunctional α receptors. In contrast, angiotensin II, by a local action on the nerve endings, can augment the release of transmitter. Decreases in local temperature reduce transmitter release but augment the affinity of the postjunctional α receptors for norepinephrine. The role of these local events at the neuroeffector junction, their physiologic significance and potential clinical importance are discussed in this review. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org | en_US |
dc.relation.ispartof | Circulation | en_US |
dc.subject.mesh | Acetylcholine - Blood | en_US |
dc.subject.mesh | Acidosis - Metabolism | en_US |
dc.subject.mesh | Adenine Nucleotides - Metabolism | en_US |
dc.subject.mesh | Adenosine - Metabolism | en_US |
dc.subject.mesh | Angiotensin Ii - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Histamine - Pharmacology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Muscle Contraction | en_US |
dc.subject.mesh | Nerve Endings - Metabolism | en_US |
dc.subject.mesh | Osmolar Concentration | en_US |
dc.subject.mesh | Potassium - Pharmacology | en_US |
dc.subject.mesh | Receptors, Adrenergic, Alpha | en_US |
dc.subject.mesh | Serotonin - Pharmacology | en_US |
dc.subject.mesh | Sympathomimetics - Pharmacology | en_US |
dc.subject.mesh | Synaptic Transmission | en_US |
dc.subject.mesh | Temperature | en_US |
dc.subject.mesh | Vasodilation | en_US |
dc.title | Local modulation of adrenergic neurotransmission | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1161/01.CIR.64.4.655 | - |
dc.identifier.pmid | 6268334 | - |
dc.identifier.scopus | eid_2-s2.0-0019442014 | en_US |
dc.identifier.volume | 64 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 655 | en_US |
dc.identifier.epage | 666 | en_US |
dc.identifier.isi | WOS:A1981MH62300001 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Shepherd, JT=7401742522 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0009-7322 | - |