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- Scopus: eid_2-s2.0-0020434502
- PMID: 6184553
- WOS: WOS:A1982PU96000004
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Article: Calcium and α-adrenoceptors in activation of vascular smooth muscle
Title | Calcium and α-adrenoceptors in activation of vascular smooth muscle |
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Authors | |
Keywords | Calcium entry blockers Extracellular calcium Vascular smooth muscle α-Adrenoceptor |
Issue Date | 1982 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ |
Citation | Journal Of Cardiovascular Pharmacology, 1982, v. 4 Suppl. 3, p. S280-S286 How to Cite? |
Abstract | Calcium entry blockers have differing effects on various vascular smooth muscle preparations during α-adrenoceptor activation. One possible explanation for these differences is that norepinephrine activates different subtypes of postjunctional α-adrenoceptors, which are linked preferentially to either the entry to extracellular or the mobilization of intracellular calcium. Therefore, differences in the sensitivity to calcium entry blockers during vasoconstrictor responses to exogenous or circulating catecholamines or to sympathetic nerve stimulation may reflect the heterogeneous pharmacological properties of the postjunctional α-adrenoceptors involved. However, depending on the blood vessel or the species studied, equally convincing evidence favoring the interpretation that either α1- or α2-adrenoceptors modulate the entry of extracellular calcium in vascular smooth muscle can be obtained. Therefore, it seems reasonable to conclude that the varying degrees of dependency of α-adrenoceptor activation on calcium entry are determined by the functional differentiation of the vascular smooth muscle cells rather than by the apparent pharmacological characteristics of their α-adrenoceptors. |
Persistent Identifier | http://hdl.handle.net/10722/170688 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Vanhoutte, PM | en_US |
dc.contributor.author | Rimele, TJ | en_US |
dc.date.accessioned | 2012-10-30T06:10:26Z | - |
dc.date.available | 2012-10-30T06:10:26Z | - |
dc.date.issued | 1982 | en_US |
dc.identifier.citation | Journal Of Cardiovascular Pharmacology, 1982, v. 4 Suppl. 3, p. S280-S286 | en_US |
dc.identifier.issn | 0160-2446 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170688 | - |
dc.description.abstract | Calcium entry blockers have differing effects on various vascular smooth muscle preparations during α-adrenoceptor activation. One possible explanation for these differences is that norepinephrine activates different subtypes of postjunctional α-adrenoceptors, which are linked preferentially to either the entry to extracellular or the mobilization of intracellular calcium. Therefore, differences in the sensitivity to calcium entry blockers during vasoconstrictor responses to exogenous or circulating catecholamines or to sympathetic nerve stimulation may reflect the heterogeneous pharmacological properties of the postjunctional α-adrenoceptors involved. However, depending on the blood vessel or the species studied, equally convincing evidence favoring the interpretation that either α1- or α2-adrenoceptors modulate the entry of extracellular calcium in vascular smooth muscle can be obtained. Therefore, it seems reasonable to conclude that the varying degrees of dependency of α-adrenoceptor activation on calcium entry are determined by the functional differentiation of the vascular smooth muscle cells rather than by the apparent pharmacological characteristics of their α-adrenoceptors. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ | en_US |
dc.relation.ispartof | Journal of Cardiovascular Pharmacology | en_US |
dc.subject | Calcium entry blockers | - |
dc.subject | Extracellular calcium | - |
dc.subject | Vascular smooth muscle | - |
dc.subject | α-Adrenoceptor | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Calcium - Physiology | en_US |
dc.subject.mesh | Diltiazem - Pharmacology | en_US |
dc.subject.mesh | Gallopamil - Pharmacology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Muscle Contraction | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Physiology | en_US |
dc.subject.mesh | Phenylephrine - Pharmacology | en_US |
dc.subject.mesh | Receptors, Adrenergic - Physiology | en_US |
dc.subject.mesh | Receptors, Adrenergic, Alpha - Physiology | en_US |
dc.subject.mesh | Verapamil - Pharmacology | en_US |
dc.title | Calcium and α-adrenoceptors in activation of vascular smooth muscle | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 6184553 | - |
dc.identifier.scopus | eid_2-s2.0-0020434502 | en_US |
dc.identifier.volume | 4 | en_US |
dc.identifier.issue | Suppl. 3 | en_US |
dc.identifier.spage | S280 | en_US |
dc.identifier.epage | S286 | en_US |
dc.identifier.isi | WOS:A1982PU96000004 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.scopusauthorid | Rimele, TJ=7004614618 | en_US |
dc.identifier.issnl | 0160-2446 | - |