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- Publisher Website: 10.1126/science.6574604
- Scopus: eid_2-s2.0-0020576969
- PMID: 6574604
- WOS: WOS:A1983QX45300032
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Article: Inhibitory role of the endothelium in the response of isolated coronary arteries to platelets
Title | Inhibitory role of the endothelium in the response of isolated coronary arteries to platelets |
---|---|
Authors | |
Issue Date | 1983 |
Publisher | American Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org |
Citation | Science, 1983, v. 221 n. 4607, p. 273-274 How to Cite? |
Abstract | Aggregating autologous platelets caused contraction of isolated rings of canine left circumflex arteries. The contractions were augmented after removal of the endothelium and were attenuated by serotonergic antagonists. During contraction caused by prostaglandin F2α, aggregating platelets caused a transient increase in tension followed by a profound relaxation of arteries with endothelium, but caused only further contraction of arteries without endothelium. These observations demonstrate the importance of the vascular endothelium in opposing the constriction of coronary vessels caused by 5-hydroxytryptamine and other substances released from aggregating platelets. |
Persistent Identifier | http://hdl.handle.net/10722/170692 |
ISSN | 2023 Impact Factor: 44.7 2023 SCImago Journal Rankings: 11.902 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cohen, RA | en_US |
dc.contributor.author | Shepherd, JT | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:10:28Z | - |
dc.date.available | 2012-10-30T06:10:28Z | - |
dc.date.issued | 1983 | en_US |
dc.identifier.citation | Science, 1983, v. 221 n. 4607, p. 273-274 | en_US |
dc.identifier.issn | 0036-8075 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170692 | - |
dc.description.abstract | Aggregating autologous platelets caused contraction of isolated rings of canine left circumflex arteries. The contractions were augmented after removal of the endothelium and were attenuated by serotonergic antagonists. During contraction caused by prostaglandin F2α, aggregating platelets caused a transient increase in tension followed by a profound relaxation of arteries with endothelium, but caused only further contraction of arteries without endothelium. These observations demonstrate the importance of the vascular endothelium in opposing the constriction of coronary vessels caused by 5-hydroxytryptamine and other substances released from aggregating platelets. | en_US |
dc.language | eng | en_US |
dc.publisher | American Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org | en_US |
dc.relation.ispartof | Science | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood Platelets - Physiology | en_US |
dc.subject.mesh | Coronary Vessels - Physiology | en_US |
dc.subject.mesh | Dinoprost | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Endothelium - Physiology | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Physiology | en_US |
dc.subject.mesh | Platelet Aggregation | en_US |
dc.subject.mesh | Prostaglandins F - Physiology | en_US |
dc.subject.mesh | Serotonin - Physiology | en_US |
dc.subject.mesh | Vasoconstriction | en_US |
dc.title | Inhibitory role of the endothelium in the response of isolated coronary arteries to platelets | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1126/science.6574604 | - |
dc.identifier.pmid | 6574604 | - |
dc.identifier.scopus | eid_2-s2.0-0020576969 | en_US |
dc.identifier.volume | 221 | en_US |
dc.identifier.issue | 4607 | en_US |
dc.identifier.spage | 273 | en_US |
dc.identifier.epage | 274 | en_US |
dc.identifier.isi | WOS:A1983QX45300032 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Cohen, RA=35562815800 | en_US |
dc.identifier.scopusauthorid | Shepherd, JT=7401742522 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0036-8075 | - |