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- Publisher Website: 10.1152/ajpheart.1983.245.6.H1073
- Scopus: eid_2-s2.0-0020997665
- PMID: 6318571
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Article: Relaxation of canine saphenous vein following brief transmural nerve stimulation.
Title | Relaxation of canine saphenous vein following brief transmural nerve stimulation. |
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Authors | |
Issue Date | 1983 |
Publisher | American Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/ |
Citation | The American Journal Of Physiology, 1983, v. 245 n. 6, p. H1073-1076 How to Cite? |
Abstract | The ability of electrical stimulation to cause relaxation in the canine saphenous vein was evaluated. Rings of vein were studied isometrically in organ chambers containing physiological salt solution. Prostaglandin F2 alpha produced stable contractions, during which brief periods of electrical stimulation caused further contraction. With cessation of the electrical stimulation, tension transiently decreased to a level below that observed prior to the stimulation (undershoot). This poststimulation undershoot was blocked by tetrodotoxin, phentolamine, ouabain, and potassium-free solution; it was not affected by atropine, cimetidine, indomethacin, ketanserin, methysergide, propranolol, pyrilamine, or removal of the endothelium. Undershoot did not occur following electrical stimulation during contractions evoked by norepinephrine. During superfusion with PGF2 alpha, a brief exposure to exogenous norepinephrine caused a transient contraction followed by a subsequent undershoot. These results suggest that 1) the interaction of norepinephrine with postjunctional alpha-adrenoceptors on vascular smooth muscle leads to an increase in the activity of Na+-K+-ATPase, and 2) increased activity of Na+-K+-ATPase is responsible for the poststimulation undershoot. |
Persistent Identifier | http://hdl.handle.net/10722/170708 |
ISSN |
DC Field | Value | Language |
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dc.contributor.author | Rooke, TW | en_US |
dc.contributor.author | Rimele, TJ | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:10:32Z | - |
dc.date.available | 2012-10-30T06:10:32Z | - |
dc.date.issued | 1983 | en_US |
dc.identifier.citation | The American Journal Of Physiology, 1983, v. 245 n. 6, p. H1073-1076 | en_US |
dc.identifier.issn | 0002-9513 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170708 | - |
dc.description.abstract | The ability of electrical stimulation to cause relaxation in the canine saphenous vein was evaluated. Rings of vein were studied isometrically in organ chambers containing physiological salt solution. Prostaglandin F2 alpha produced stable contractions, during which brief periods of electrical stimulation caused further contraction. With cessation of the electrical stimulation, tension transiently decreased to a level below that observed prior to the stimulation (undershoot). This poststimulation undershoot was blocked by tetrodotoxin, phentolamine, ouabain, and potassium-free solution; it was not affected by atropine, cimetidine, indomethacin, ketanserin, methysergide, propranolol, pyrilamine, or removal of the endothelium. Undershoot did not occur following electrical stimulation during contractions evoked by norepinephrine. During superfusion with PGF2 alpha, a brief exposure to exogenous norepinephrine caused a transient contraction followed by a subsequent undershoot. These results suggest that 1) the interaction of norepinephrine with postjunctional alpha-adrenoceptors on vascular smooth muscle leads to an increase in the activity of Na+-K+-ATPase, and 2) increased activity of Na+-K+-ATPase is responsible for the poststimulation undershoot. | en_US |
dc.language | eng | en_US |
dc.publisher | American Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/ | en_US |
dc.relation.ispartof | The American journal of physiology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Dinoprost | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Electric Stimulation | en_US |
dc.subject.mesh | Isometric Contraction - Drug Effects | en_US |
dc.subject.mesh | Muscle Contraction - Drug Effects | en_US |
dc.subject.mesh | Muscle Relaxation | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Physiology | en_US |
dc.subject.mesh | Norepinephrine - Pharmacology | en_US |
dc.subject.mesh | Perfusion | en_US |
dc.subject.mesh | Prostaglandins F - Pharmacology | en_US |
dc.subject.mesh | Saphenous Vein - Drug Effects - Innervation - Physiology | en_US |
dc.subject.mesh | Sodium-Potassium-Exchanging Atpase - Metabolism | en_US |
dc.title | Relaxation of canine saphenous vein following brief transmural nerve stimulation. | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1152/ajpheart.1983.245.6.H1073 | - |
dc.identifier.pmid | 6318571 | - |
dc.identifier.scopus | eid_2-s2.0-0020997665 | en_US |
dc.identifier.volume | 245 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | H1073 | en_US |
dc.identifier.epage | 1076 | en_US |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Rooke, TW=8757981200 | en_US |
dc.identifier.scopusauthorid | Rimele, TJ=7004614618 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0002-9513 | - |