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- Publisher Website: 10.1152/ajpheart.1984.247.3.H403
- Scopus: eid_2-s2.0-0021487549
- PMID: 6476135
- WOS: WOS:A1984TK40500008
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Article: Endothelium and asymmetrical responses of the coronary arterial wall
Title | Endothelium and asymmetrical responses of the coronary arterial wall |
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Authors | |
Issue Date | 1984 |
Publisher | American Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/ |
Citation | The American Journal Of Physiology, 1984, v. 247 n. 3 Pt 2, p. H403-408 How to Cite? |
Abstract | Changes in isometric tension due to intra- or extraluminal addition of vasoactive agents were determined in isolated perfused segments of canine left circumflex coronary artery. Segments denuded of endothelium were more sensitive to the contractile action of 5-hydroxytryptamine and potassium during intraluminal addition. In segments with intact endothelium, the sensitivity to intraluminal, but not extraluminal, 5-hydroxytryptamine was decreased in comparison to denuded segments; that to potassium was unchanged. In segments with intact endothelium contracted with prostaglandin F2 alpha, intraluminal, but not extraluminal, acetylcholine, adenosine diphosphate, or thrombin caused relaxation. Intraluminal 5-hydroxytryptamine and aggregating platelets caused relaxation or attenuated contractions in a majority of vessels studied; extraluminal addition caused only contractions. Thus the endothelium is responsible for opposite smooth muscle responses to intra- versus extraluminal vasoactive substances released from aggregating platelets. During intraluminal thrombosis the endothelium may inhibit smooth muscle contraction by responding to 5-hydroxytryptamine and adenosine diphosphate released from platelets and to thrombin; where the endothelium is damaged, the luminal aspect of the blood vessel wall, which is more sensitive to 5-hydroxytryptamine, may become the site of coronary spasm. |
Persistent Identifier | http://hdl.handle.net/10722/170746 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cohen, RA | en_US |
dc.contributor.author | Shepherd, JT | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:10:41Z | - |
dc.date.available | 2012-10-30T06:10:41Z | - |
dc.date.issued | 1984 | en_US |
dc.identifier.citation | The American Journal Of Physiology, 1984, v. 247 n. 3 Pt 2, p. H403-408 | en_US |
dc.identifier.issn | 0002-9513 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170746 | - |
dc.description.abstract | Changes in isometric tension due to intra- or extraluminal addition of vasoactive agents were determined in isolated perfused segments of canine left circumflex coronary artery. Segments denuded of endothelium were more sensitive to the contractile action of 5-hydroxytryptamine and potassium during intraluminal addition. In segments with intact endothelium, the sensitivity to intraluminal, but not extraluminal, 5-hydroxytryptamine was decreased in comparison to denuded segments; that to potassium was unchanged. In segments with intact endothelium contracted with prostaglandin F2 alpha, intraluminal, but not extraluminal, acetylcholine, adenosine diphosphate, or thrombin caused relaxation. Intraluminal 5-hydroxytryptamine and aggregating platelets caused relaxation or attenuated contractions in a majority of vessels studied; extraluminal addition caused only contractions. Thus the endothelium is responsible for opposite smooth muscle responses to intra- versus extraluminal vasoactive substances released from aggregating platelets. During intraluminal thrombosis the endothelium may inhibit smooth muscle contraction by responding to 5-hydroxytryptamine and adenosine diphosphate released from platelets and to thrombin; where the endothelium is damaged, the luminal aspect of the blood vessel wall, which is more sensitive to 5-hydroxytryptamine, may become the site of coronary spasm. | en_US |
dc.language | eng | en_US |
dc.publisher | American Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/ | en_US |
dc.relation.ispartof | The American journal of physiology | en_US |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Adenosine Diphosphate - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Arteries | en_US |
dc.subject.mesh | Blood Platelets | en_US |
dc.subject.mesh | Coronary Vessels - Physiology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Endothelium - Physiology | en_US |
dc.subject.mesh | Muscle Contraction - Drug Effects | en_US |
dc.subject.mesh | Muscle Relaxation | en_US |
dc.subject.mesh | Potassium - Pharmacology | en_US |
dc.subject.mesh | Prostaglandins F - Pharmacology | en_US |
dc.subject.mesh | Serotonin - Pharmacology | en_US |
dc.subject.mesh | Thrombin - Pharmacology | en_US |
dc.title | Endothelium and asymmetrical responses of the coronary arterial wall | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1152/ajpheart.1984.247.3.H403 | - |
dc.identifier.pmid | 6476135 | - |
dc.identifier.scopus | eid_2-s2.0-0021487549 | en_US |
dc.identifier.volume | 247 | en_US |
dc.identifier.issue | 3 Pt 2 | en_US |
dc.identifier.spage | H403 | en_US |
dc.identifier.epage | H408 | en_US |
dc.identifier.isi | WOS:A1984TK40500008 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Cohen, RA=35562815800 | en_US |
dc.identifier.scopusauthorid | Shepherd, JT=7401742522 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0002-9513 | - |