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- Publisher Website: 10.1113/jphysiol.1985.sp015728
- Scopus: eid_2-s2.0-0021891159
- PMID: 3861856
- WOS: WOS:A1985AMT3300004
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Article: Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium
Title | Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium |
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Authors | |
Issue Date | 1985 |
Publisher | Wiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3751 |
Citation | Journal Of Physiology, 1985, v. VOL. 364, p. 45-56 How to Cite? |
Abstract | 1. Experiments were designed to determine the role of the endothelium in the facilitation by anoxia of contractile responses of isolated coronary arteries. 2. Rings and strips of canine coronary arteries, with or without endothelium, were suspended for isometric tension recording in modified Krebs-Ringer bicarbonate solution. To determine the release of a vasoactive substance(s) from the endothelial cells, strips without endothelium were layered with strips containing endothelium. 3. In rings and in layered preparations with endothelium, anoxia (95% N2-5% CO2) augmented contractile responses to prostaglandin F(2α). Hypoxia (10 or 5% O2) caused contractions in the presence of indomethacin. Removal of the endothelium abolished the anoxic facilitation, and the hypoxic contractions. 4. Inhibitors of cyclo-oxygenase, lipoxygenase or phospholipase A2 or of adrenergic, serotonergic and histaminergic receptors did not prevent the response to anoxia. Likewise, inhibitors of the endothelium-derived factor(s) (quinacrine, phenidone and methylene blue) did not affect the anoxic facilitation. 5. Hypoxia and anoxia caused contraction of coronary arteries without endothelium when layered with femoral arteries and veins with endothelium. Anoxic facilitation was observed in femoral arteries, but not in femoral veins, with endothelium. 6. These experiments indicate that hypoxia and anoxia cause the release of a diffusible vasoconstrictor substance(s) from endothelial cells. The sensitivity of smooth muscle of different anatomical origin to the facilitatory mediator(s) varies. |
Persistent Identifier | http://hdl.handle.net/10722/170771 |
ISSN | 2023 Impact Factor: 4.7 2023 SCImago Journal Rankings: 1.708 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Rubanyi, GM | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:10:47Z | - |
dc.date.available | 2012-10-30T06:10:47Z | - |
dc.date.issued | 1985 | en_US |
dc.identifier.citation | Journal Of Physiology, 1985, v. VOL. 364, p. 45-56 | en_US |
dc.identifier.issn | 0022-3751 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170771 | - |
dc.description.abstract | 1. Experiments were designed to determine the role of the endothelium in the facilitation by anoxia of contractile responses of isolated coronary arteries. 2. Rings and strips of canine coronary arteries, with or without endothelium, were suspended for isometric tension recording in modified Krebs-Ringer bicarbonate solution. To determine the release of a vasoactive substance(s) from the endothelial cells, strips without endothelium were layered with strips containing endothelium. 3. In rings and in layered preparations with endothelium, anoxia (95% N2-5% CO2) augmented contractile responses to prostaglandin F(2α). Hypoxia (10 or 5% O2) caused contractions in the presence of indomethacin. Removal of the endothelium abolished the anoxic facilitation, and the hypoxic contractions. 4. Inhibitors of cyclo-oxygenase, lipoxygenase or phospholipase A2 or of adrenergic, serotonergic and histaminergic receptors did not prevent the response to anoxia. Likewise, inhibitors of the endothelium-derived factor(s) (quinacrine, phenidone and methylene blue) did not affect the anoxic facilitation. 5. Hypoxia and anoxia caused contraction of coronary arteries without endothelium when layered with femoral arteries and veins with endothelium. Anoxic facilitation was observed in femoral arteries, but not in femoral veins, with endothelium. 6. These experiments indicate that hypoxia and anoxia cause the release of a diffusible vasoconstrictor substance(s) from endothelial cells. The sensitivity of smooth muscle of different anatomical origin to the facilitatory mediator(s) varies. | en_US |
dc.language | eng | en_US |
dc.publisher | Wiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3751 | en_US |
dc.relation.ispartof | Journal of Physiology | en_US |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Adenosine Diphosphate - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Coronary Vessels - Physiology | en_US |
dc.subject.mesh | Dinoprost | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Endothelium - Physiology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Indomethacin - Pharmacology | en_US |
dc.subject.mesh | Isometric Contraction | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Methylene Blue - Pharmacology | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Physiology | en_US |
dc.subject.mesh | Oxygen - Physiology | en_US |
dc.subject.mesh | Prostaglandins F - Pharmacology | en_US |
dc.subject.mesh | Pyrazoles - Pharmacology | en_US |
dc.subject.mesh | Quinacrine - Pharmacology | en_US |
dc.subject.mesh | Vasoconstriction - Drug Effects | en_US |
dc.title | Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1113/jphysiol.1985.sp015728 | - |
dc.identifier.pmid | 3861856 | - |
dc.identifier.scopus | eid_2-s2.0-0021891159 | en_US |
dc.identifier.volume | VOL. 364 | en_US |
dc.identifier.spage | 45 | en_US |
dc.identifier.epage | 56 | en_US |
dc.identifier.isi | WOS:A1985AMT3300004 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Rubanyi, GM=7005517991 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0022-3751 | - |