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- Publisher Website: 10.1152/ajpheart.1985.249.3.H685
- Scopus: eid_2-s2.0-0022119870
- PMID: 4037113
- WOS: WOS:A1985AQW2900031
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Article: Prejunctional adrenergic inhibition by aggregating platelets in canine blood vessels
Title | Prejunctional adrenergic inhibition by aggregating platelets in canine blood vessels |
---|---|
Authors | |
Issue Date | 1985 |
Publisher | American Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/ |
Citation | The American Journal Of Physiology, 1985, v. 249 n. 3 Pt 2, p. H685-689 How to Cite? |
Abstract | Experiments were performed to determine the effect of aggregating platelets on adrenergic neurotransmission. Rings of canine saphenous veins and left circumflex coronary arteries were incubated with [3H]norepinephrine and suspended for superfusion. Aggregating platelets and exogenous 5-hydroxytryptamine decreased the overflow of [3H]norepinephrine evoked by electrical stimulation of the adrenergic nerve endings. The reduction of transmitter overflow caused by 5-hydroxytryptamine was prevented by the serotonergic antagonist methiothepin in a concentration that did not significantly affect the release of 5-hydroxytryptamine or thromboxane B2 from the aggregating platelets. Methiothepin decreased but did not abolish the inhibitory effect of aggregating platelets on neurotransmitter overflow. These experiments demonstrate that 5-hydroxytryptamine and other substances released from aggregating platelets can exert prejunctional inhibition of adrenergic neurotransmission in isolated blood vessels. |
Persistent Identifier | http://hdl.handle.net/10722/170786 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lorenz, RR | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:10:51Z | - |
dc.date.available | 2012-10-30T06:10:51Z | - |
dc.date.issued | 1985 | en_US |
dc.identifier.citation | The American Journal Of Physiology, 1985, v. 249 n. 3 Pt 2, p. H685-689 | en_US |
dc.identifier.issn | 0002-9513 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170786 | - |
dc.description.abstract | Experiments were performed to determine the effect of aggregating platelets on adrenergic neurotransmission. Rings of canine saphenous veins and left circumflex coronary arteries were incubated with [3H]norepinephrine and suspended for superfusion. Aggregating platelets and exogenous 5-hydroxytryptamine decreased the overflow of [3H]norepinephrine evoked by electrical stimulation of the adrenergic nerve endings. The reduction of transmitter overflow caused by 5-hydroxytryptamine was prevented by the serotonergic antagonist methiothepin in a concentration that did not significantly affect the release of 5-hydroxytryptamine or thromboxane B2 from the aggregating platelets. Methiothepin decreased but did not abolish the inhibitory effect of aggregating platelets on neurotransmitter overflow. These experiments demonstrate that 5-hydroxytryptamine and other substances released from aggregating platelets can exert prejunctional inhibition of adrenergic neurotransmission in isolated blood vessels. | en_US |
dc.language | eng | en_US |
dc.publisher | American Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/ | en_US |
dc.relation.ispartof | The American journal of physiology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood Platelets - Metabolism | en_US |
dc.subject.mesh | Coronary Vessels - Physiology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Electric Stimulation | en_US |
dc.subject.mesh | Methiothepin - Pharmacology | en_US |
dc.subject.mesh | Muscle Contraction | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Drug Effects - Physiology | en_US |
dc.subject.mesh | Norepinephrine - Physiology | en_US |
dc.subject.mesh | Phentolamine - Pharmacology | en_US |
dc.subject.mesh | Platelet Aggregation - Drug Effects | en_US |
dc.subject.mesh | Saphenous Vein - Physiology | en_US |
dc.subject.mesh | Serotonin - Blood - Pharmacology | en_US |
dc.subject.mesh | Thromboxane B2 - Blood | en_US |
dc.title | Prejunctional adrenergic inhibition by aggregating platelets in canine blood vessels | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1152/ajpheart.1985.249.3.H685 | - |
dc.identifier.pmid | 4037113 | - |
dc.identifier.scopus | eid_2-s2.0-0022119870 | en_US |
dc.identifier.volume | 249 | en_US |
dc.identifier.issue | 3 Pt 2 | en_US |
dc.identifier.spage | H685 | en_US |
dc.identifier.epage | H689 | en_US |
dc.identifier.isi | WOS:A1985AQW2900031 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lorenz, RR=7402095192 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0002-9513 | - |