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- Publisher Website: 10.1172/JCI112606
- Scopus: eid_2-s2.0-0022495286
- PMID: 3734103
- WOS: WOS:A1986D423600027
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Article: Aggregating human platelets cause direct contraction and endothelium-dependent relaxation of isolated canine coronary arteries. Role of serotonin, thromboxane A2, and adenine nucleotides
Title | Aggregating human platelets cause direct contraction and endothelium-dependent relaxation of isolated canine coronary arteries. Role of serotonin, thromboxane A2, and adenine nucleotides |
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Authors | |
Issue Date | 1986 |
Publisher | American Society for Clinical Investigation. The Journal's web site is located at http://www.jci.org |
Citation | Journal Of Clinical Investigation, 1986, v. 78 n. 2, p. 539-544 How to Cite? |
Abstract | Aggregating human platelets contract isolated rings of canine coronary artery without endothelium, but relax rings with intact endothelium. We performed experiments to identify the substances released from platelets responsible for these effects. The contraction in rings without endothelium was reduced by treating the platelets with the thromboxane synthetase inhibitor, dazoxiben, or treating the vessels with the thromboxane-receptor antagonist, SQ 29548. The serotonergic antagonist, methiothepin, also reduced the platelet-induced contraction. The combination of methiothepin plus dazoxiben or SQ 29548 caused a further inhibition. The endothelium-dependent relaxation to platelets during contractions evoked by prostaglandin F(2α) was nearly abolished by the ADP- and ATP-scavenger, apyrase. It was not inhibited by methiothepin, which antagonizes endothelium-dependent relaxations to serotonin. Thus, both serotonin and thromboxane A2 contribute to the direct activation of coronary smooth muscle by aggregating human platelets, whereas adenine nucleotides are the principal mediators of the endothelium-dependent relaxation. |
Persistent Identifier | http://hdl.handle.net/10722/170812 |
ISSN | 2023 Impact Factor: 13.3 2023 SCImago Journal Rankings: 4.833 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Houston, DS | en_US |
dc.contributor.author | Shepherd, JT | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:10:58Z | - |
dc.date.available | 2012-10-30T06:10:58Z | - |
dc.date.issued | 1986 | en_US |
dc.identifier.citation | Journal Of Clinical Investigation, 1986, v. 78 n. 2, p. 539-544 | en_US |
dc.identifier.issn | 0021-9738 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170812 | - |
dc.description.abstract | Aggregating human platelets contract isolated rings of canine coronary artery without endothelium, but relax rings with intact endothelium. We performed experiments to identify the substances released from platelets responsible for these effects. The contraction in rings without endothelium was reduced by treating the platelets with the thromboxane synthetase inhibitor, dazoxiben, or treating the vessels with the thromboxane-receptor antagonist, SQ 29548. The serotonergic antagonist, methiothepin, also reduced the platelet-induced contraction. The combination of methiothepin plus dazoxiben or SQ 29548 caused a further inhibition. The endothelium-dependent relaxation to platelets during contractions evoked by prostaglandin F(2α) was nearly abolished by the ADP- and ATP-scavenger, apyrase. It was not inhibited by methiothepin, which antagonizes endothelium-dependent relaxations to serotonin. Thus, both serotonin and thromboxane A2 contribute to the direct activation of coronary smooth muscle by aggregating human platelets, whereas adenine nucleotides are the principal mediators of the endothelium-dependent relaxation. | en_US |
dc.language | eng | en_US |
dc.publisher | American Society for Clinical Investigation. The Journal's web site is located at http://www.jci.org | en_US |
dc.relation.ispartof | Journal of Clinical Investigation | en_US |
dc.subject.mesh | Adenine Nucleotides - Physiology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Coronary Vessels - Metabolism - Physiology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Endothelium - Physiology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Imidazoles - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Methiothepin - Pharmacology | en_US |
dc.subject.mesh | Muscle Contraction - Drug Effects | en_US |
dc.subject.mesh | Muscle Relaxation - Drug Effects | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Metabolism - Physiology | en_US |
dc.subject.mesh | Platelet Aggregation | en_US |
dc.subject.mesh | Serotonin - Metabolism - Pharmacology - Physiology | en_US |
dc.subject.mesh | Thromboxane A2 - Physiology | en_US |
dc.subject.mesh | Thromboxane B2 - Metabolism | en_US |
dc.title | Aggregating human platelets cause direct contraction and endothelium-dependent relaxation of isolated canine coronary arteries. Role of serotonin, thromboxane A2, and adenine nucleotides | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1172/JCI112606 | - |
dc.identifier.pmid | 3734103 | - |
dc.identifier.scopus | eid_2-s2.0-0022495286 | en_US |
dc.identifier.volume | 78 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 539 | en_US |
dc.identifier.epage | 544 | en_US |
dc.identifier.isi | WOS:A1986D423600027 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Houston, DS=35966326400 | en_US |
dc.identifier.scopusauthorid | Shepherd, JT=7401742522 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0021-9738 | - |