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Article: Characterization of muscarinic receptors in canine bronchial smooth muscle

TitleCharacterization of muscarinic receptors in canine bronchial smooth muscle
Authors
O'rourke, STFlavahan, NAVanhoutte, PM
Keywords(Canine)
Acetylcholine
Bronchi
Electrical stimulation
Muscarinic receptors
Pancuronium
Pirenzepine
Issue Date1987
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1987, v. 140 n. 1, p. 117-120 How to Cite?
DOI: http://dx.doi.org/10.1016/0014-2999(87)90643-1
AbstractRings of canine bronchi were suspended for isometric tension recording. Contractions produced by exogenously added acetylcholine were inhibited by pirenzepine and pancuronium. The pK(B) values were 6.76 for pirenzepine (calculated at 10-6 M) and 5.30 and 5.13 for pancuronium (calculated at 10-5 and 3x10-5 M, respectively). Contractile responses evoked by cholinergic nerve stimulation (0.2-16 Hz, 9 V) were depressed by pancuronium in a concentration-dependent manner, while concentrations of pirenzepine selective for M1-muscarinic receptors were without effect. The results indicate that exogenous and nerve-released acetylcholine activate a homogenous population of M2-muscarinic receptors in isolated preparations of canine bronchial smooth muscle.
Persistent Identifierhttp://hdl.handle.net/10722/170847
ISSN
0014-2999
2023 Impact Factor: 4.2
2023 SCImago Journal Rankings: 1.055
ISI Accession Number ID
WOS:A1987J564400017

 

DC FieldValueLanguage
dc.contributor.authorO'rourke, STen_US
dc.contributor.authorFlavahan, NAen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:06Z-
dc.date.available2012-10-30T06:11:06Z-
dc.date.issued1987en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 1987, v. 140 n. 1, p. 117-120en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/170847-
dc.description.abstractRings of canine bronchi were suspended for isometric tension recording. Contractions produced by exogenously added acetylcholine were inhibited by pirenzepine and pancuronium. The pK(B) values were 6.76 for pirenzepine (calculated at 10-6 M) and 5.30 and 5.13 for pancuronium (calculated at 10-5 and 3x10-5 M, respectively). Contractile responses evoked by cholinergic nerve stimulation (0.2-16 Hz, 9 V) were depressed by pancuronium in a concentration-dependent manner, while concentrations of pirenzepine selective for M1-muscarinic receptors were without effect. The results indicate that exogenous and nerve-released acetylcholine activate a homogenous population of M2-muscarinic receptors in isolated preparations of canine bronchial smooth muscle.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject(Canine)-
dc.subjectAcetylcholine-
dc.subjectBronchi-
dc.subjectElectrical stimulation-
dc.subjectMuscarinic receptors-
dc.subjectPancuronium-
dc.subjectPirenzepine-
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBronchi - Drug Effectsen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth - Drug Effectsen_US
dc.subject.meshPancuronium - Pharmacologyen_US
dc.subject.meshParasympathetic Nervous System - Physiologyen_US
dc.subject.meshPirenzepine - Pharmacologyen_US
dc.subject.meshReceptors, Muscarinic - Drug Effectsen_US
dc.titleCharacterization of muscarinic receptors in canine bronchial smooth muscleen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-2999(87)90643-1-
dc.identifier.pmid3622620-
dc.identifier.scopuseid_2-s2.0-0023183233en_US
dc.identifier.volume140en_US
dc.identifier.issue1en_US
dc.identifier.spage117en_US
dc.identifier.epage120en_US
dc.identifier.isiWOS:A1987J564400017-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridO'Rourke, ST=7005313078en_US
dc.identifier.scopusauthoridFlavahan, NA=7006398882en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.issnl0014-2999-

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