File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/0091-3057(89)90355-9
- Scopus: eid_2-s2.0-0024377247
- PMID: 2516633
- WOS: WOS:A1989AZ59700013
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: The antiulcer effect of verapamil in relation to gastric calcium levels in stressed rats
Title | The antiulcer effect of verapamil in relation to gastric calcium levels in stressed rats |
---|---|
Authors | |
Keywords | Calcium Calcium gluconate EGTA Stress ulceration Verapamil |
Issue Date | 1989 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembeh |
Citation | Pharmacology Biochemistry And Behavior, 1989, v. 34 n. 1, p. 73-76 How to Cite? |
Abstract | The antiulcer effect of verapamil, and its relationship to stomach calcium levels, were examined in rats restrained at 4°C (stress). Stress for 2 hr significantly increased muscle calcium and induced mucosal ulceration in the gastric glandular segment; calcium concentrations in the glandular mucosa and serum were unaffected. Verapamil or calcium gluconate given 30 min before stress prevented the rise in gastric muscle calcium, and attenuated ulcer severity. Bis(β-aminoethylether)-NNN'N'-tetra-acetic acid (EGTA) pretreatment, however, further elevated stomach muscle calcium and markedly worsened lesion formation. These findings suggest that increased stomach muscle calcium could be a causal factor in stress-induced gastric glandular ulceration. |
Persistent Identifier | http://hdl.handle.net/10722/170926 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 1.050 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koo, MWL | en_US |
dc.contributor.author | Cho, CH | en_US |
dc.contributor.author | Ogle, CW | en_US |
dc.date.accessioned | 2012-10-30T06:11:27Z | - |
dc.date.available | 2012-10-30T06:11:27Z | - |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | Pharmacology Biochemistry And Behavior, 1989, v. 34 n. 1, p. 73-76 | en_US |
dc.identifier.issn | 0091-3057 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170926 | - |
dc.description.abstract | The antiulcer effect of verapamil, and its relationship to stomach calcium levels, were examined in rats restrained at 4°C (stress). Stress for 2 hr significantly increased muscle calcium and induced mucosal ulceration in the gastric glandular segment; calcium concentrations in the glandular mucosa and serum were unaffected. Verapamil or calcium gluconate given 30 min before stress prevented the rise in gastric muscle calcium, and attenuated ulcer severity. Bis(β-aminoethylether)-NNN'N'-tetra-acetic acid (EGTA) pretreatment, however, further elevated stomach muscle calcium and markedly worsened lesion formation. These findings suggest that increased stomach muscle calcium could be a causal factor in stress-induced gastric glandular ulceration. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembeh | en_US |
dc.relation.ispartof | Pharmacology Biochemistry and Behavior | en_US |
dc.subject | Calcium | - |
dc.subject | Calcium gluconate | - |
dc.subject | EGTA | - |
dc.subject | Stress ulceration | - |
dc.subject | Verapamil | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Calcium - Analysis - Blood | en_US |
dc.subject.mesh | Calcium Gluconate - Administration & Dosage - Pharmacology - Therapeutic Use | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Egtazic Acid - Administration & Dosage - Pharmacology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Strains | en_US |
dc.subject.mesh | Restraint, Physical | en_US |
dc.subject.mesh | Stomach - Analysis | en_US |
dc.subject.mesh | Stomach Ulcer - Prevention & Control | en_US |
dc.subject.mesh | Stress, Physiological - Metabolism | en_US |
dc.subject.mesh | Verapamil - Administration & Dosage - Pharmacology - Therapeutic Use | en_US |
dc.title | The antiulcer effect of verapamil in relation to gastric calcium levels in stressed rats | en_US |
dc.type | Article | en_US |
dc.identifier.email | Koo, MWL:wlkoo@hku.hk | en_US |
dc.identifier.authority | Koo, MWL=rp00233 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0091-3057(89)90355-9 | en_US |
dc.identifier.pmid | 2516633 | - |
dc.identifier.scopus | eid_2-s2.0-0024377247 | en_US |
dc.identifier.volume | 34 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 73 | en_US |
dc.identifier.epage | 76 | en_US |
dc.identifier.isi | WOS:A1989AZ59700013 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Koo, MWL=7004550899 | en_US |
dc.identifier.scopusauthorid | Cho, CH=14067000400 | en_US |
dc.identifier.scopusauthorid | Ogle, CW=7103150233 | en_US |
dc.identifier.issnl | 0091-3057 | - |