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- Publisher Website: 10.1139/y89-120
- Scopus: eid_2-s2.0-0024416521
- PMID: 2504469
- WOS: WOS:A1989AM59200010
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Article: Electrophysiological effects of encainide and its metabolites in normal canine Purkinje fibers and Purkinje fibers surviving infarction
Title | Electrophysiological effects of encainide and its metabolites in normal canine Purkinje fibers and Purkinje fibers surviving infarction |
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Authors | |
Issue Date | 1989 |
Publisher | N R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjpp |
Citation | Canadian Journal Of Physiology And Pharmacology, 1989, v. 67 n. 7, p. 751-756 How to Cite? |
Abstract | In this study, we assessed the effects of O-demethyl encainide (0.5 μM), the most active metabolite of encainide, and the combination with 3-methoxy-O-demethyl encainide (0.5 μM), and encainide (0.1 μM) on cardiac action potential characteristics in normal canine Purkinje fibers and Purkinje fibers surviving 24 h of myocardial ischemia. O-demethyl encainide decreased V̇(max) and conduction in normal Purkinje fibers and Purkinje fibers surviving infarction. Further decreases were observed with the combination. Action potential duration at both 50 and 95% repolarization was decreased by O-demethyl encainide. The combination of O-demethyl encainide, 3-methoxy-O-demethyl encainide, and encainide had no further effect. The combination of O-demethyl encainide, 3-methoxy-O-demethyl encainide, and encainide produced a smaller change in effective refractory period than O-demethyl encainide in normal Purkinje fibers and Purkinje fibers surviving infarction. O-demethyl encainide and the combination shifted the membrane responsiveness curve to more negative potentials in both normal Purkinje fibers and Purkinje fibers surviving infarction. It is apparent from this study that there are differences in the effects of O-demethyl encainide and the combination of O-demethyl encainide, 3-methoxy-O-demethyl encainide, and encainide in normal Purkinje fibers compared with Purkinje fibers surviving infarction. Also, the combination used in this study had different electrophysiological effects than those of O-demethyl encainide alone. |
Persistent Identifier | http://hdl.handle.net/10722/170933 |
ISSN | 2023 Impact Factor: 1.7 2023 SCImago Journal Rankings: 0.499 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kinnaird, AAA | en_US |
dc.contributor.author | Man, RYK | en_US |
dc.date.accessioned | 2012-10-30T06:11:29Z | - |
dc.date.available | 2012-10-30T06:11:29Z | - |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | Canadian Journal Of Physiology And Pharmacology, 1989, v. 67 n. 7, p. 751-756 | en_US |
dc.identifier.issn | 0008-4212 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170933 | - |
dc.description.abstract | In this study, we assessed the effects of O-demethyl encainide (0.5 μM), the most active metabolite of encainide, and the combination with 3-methoxy-O-demethyl encainide (0.5 μM), and encainide (0.1 μM) on cardiac action potential characteristics in normal canine Purkinje fibers and Purkinje fibers surviving 24 h of myocardial ischemia. O-demethyl encainide decreased V̇(max) and conduction in normal Purkinje fibers and Purkinje fibers surviving infarction. Further decreases were observed with the combination. Action potential duration at both 50 and 95% repolarization was decreased by O-demethyl encainide. The combination of O-demethyl encainide, 3-methoxy-O-demethyl encainide, and encainide had no further effect. The combination of O-demethyl encainide, 3-methoxy-O-demethyl encainide, and encainide produced a smaller change in effective refractory period than O-demethyl encainide in normal Purkinje fibers and Purkinje fibers surviving infarction. O-demethyl encainide and the combination shifted the membrane responsiveness curve to more negative potentials in both normal Purkinje fibers and Purkinje fibers surviving infarction. It is apparent from this study that there are differences in the effects of O-demethyl encainide and the combination of O-demethyl encainide, 3-methoxy-O-demethyl encainide, and encainide in normal Purkinje fibers compared with Purkinje fibers surviving infarction. Also, the combination used in this study had different electrophysiological effects than those of O-demethyl encainide alone. | en_US |
dc.language | eng | en_US |
dc.publisher | N R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjpp | en_US |
dc.relation.ispartof | Canadian Journal of Physiology and Pharmacology | en_US |
dc.subject.mesh | Action Potentials - Drug Effects | en_US |
dc.subject.mesh | Anilides - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Anti-Arrhythmia Agents - Pharmacology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Encainide | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Heart Conduction System - Drug Effects | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Myocardial Infarction - Physiopathology | en_US |
dc.subject.mesh | Purkinje Fibers - Drug Effects - Physiopathology | en_US |
dc.title | Electrophysiological effects of encainide and its metabolites in normal canine Purkinje fibers and Purkinje fibers surviving infarction | en_US |
dc.type | Article | en_US |
dc.identifier.email | Man, RYK:rykman@hkucc.hku.hk | en_US |
dc.identifier.authority | Man, RYK=rp00236 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1139/y89-120 | - |
dc.identifier.pmid | 2504469 | - |
dc.identifier.scopus | eid_2-s2.0-0024416521 | en_US |
dc.identifier.volume | 67 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.spage | 751 | en_US |
dc.identifier.epage | 756 | en_US |
dc.identifier.isi | WOS:A1989AM59200010 | - |
dc.publisher.place | Canada | en_US |
dc.identifier.scopusauthorid | Kinnaird, AAA=6603472891 | en_US |
dc.identifier.scopusauthorid | Man, RYK=7004986435 | en_US |
dc.identifier.issnl | 0008-4212 | - |