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- Publisher Website: 10.1007/BF02537977
- Scopus: eid_2-s2.0-0025269871
- PMID: 2395414
- WOS: WOS:A1990DP79600001
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Article: Mechanism of lysophosphatidylcholine accumulation in the ischemic canine heart
Title | Mechanism of lysophosphatidylcholine accumulation in the ischemic canine heart |
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Authors | |
Issue Date | 1990 |
Publisher | A O C S Press. The Journal's web site is located at http://www.aocs.org/press/lipids.htm |
Citation | Lipids, 1990, v. 25 n. 7, p. 357-362 How to Cite? |
Abstract | The metabolism of lysophosphatidylcholine (LPC) in non-ischemic and ischemic canine heart was investigated by in vitro enzyme analysis. Selected subcellular fractions were assayed for the LPC-producing enzyme phospholipase A and the LPC-eliminating enzymes LPC:acyl-CoA acyltransferase, LPC:LPC transacylase and lysophospholipase. The canine heart was found to contain all enzymes differing, however, in subcellular distribution and specific activity. Phospholipase A activity did not change significantly in any of the fractions prepared from the ischemic tissue of hearts rendered ischemic for 1,3 or 5 hr when compared to non-ischemic tissue. Changes in the activity of the microsomal LPC:acyl-CoA acyltransferase over the course of 5 hr of ischemia were observed. Significant decreases in the activity of the cytosolic and microsomal lysophospholipases were detected especially after 3 and 5 hr of ischemia. Similarly, a decrease in the activity of the microsomal LPC:LPC transacylase was noted after 3 and 5 hr of ischemia. Our results suggest that impaired catabolism of LPC rather than an enhanced production of LPC is the principal mechanism for the increase in LPC levels in the ischemic canine heart. |
Persistent Identifier | http://hdl.handle.net/10722/170985 |
ISSN | 2023 Impact Factor: 1.8 2023 SCImago Journal Rankings: 0.438 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Mock, T | en_US |
dc.contributor.author | Man, RYK | en_US |
dc.date.accessioned | 2012-10-30T06:11:43Z | - |
dc.date.available | 2012-10-30T06:11:43Z | - |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Lipids, 1990, v. 25 n. 7, p. 357-362 | en_US |
dc.identifier.issn | 0024-4201 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170985 | - |
dc.description.abstract | The metabolism of lysophosphatidylcholine (LPC) in non-ischemic and ischemic canine heart was investigated by in vitro enzyme analysis. Selected subcellular fractions were assayed for the LPC-producing enzyme phospholipase A and the LPC-eliminating enzymes LPC:acyl-CoA acyltransferase, LPC:LPC transacylase and lysophospholipase. The canine heart was found to contain all enzymes differing, however, in subcellular distribution and specific activity. Phospholipase A activity did not change significantly in any of the fractions prepared from the ischemic tissue of hearts rendered ischemic for 1,3 or 5 hr when compared to non-ischemic tissue. Changes in the activity of the microsomal LPC:acyl-CoA acyltransferase over the course of 5 hr of ischemia were observed. Significant decreases in the activity of the cytosolic and microsomal lysophospholipases were detected especially after 3 and 5 hr of ischemia. Similarly, a decrease in the activity of the microsomal LPC:LPC transacylase was noted after 3 and 5 hr of ischemia. Our results suggest that impaired catabolism of LPC rather than an enhanced production of LPC is the principal mechanism for the increase in LPC levels in the ischemic canine heart. | en_US |
dc.language | eng | en_US |
dc.publisher | A O C S Press. The Journal's web site is located at http://www.aocs.org/press/lipids.htm | en_US |
dc.relation.ispartof | Lipids | en_US |
dc.subject.mesh | 1-Acylglycerophosphocholine O-Acyltransferase - Metabolism | en_US |
dc.subject.mesh | Acyltransferases - Metabolism | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Coronary Disease - Metabolism | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Lysophosphatidylcholines - Metabolism | en_US |
dc.subject.mesh | Lysophospholipase - Metabolism | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Multienzyme Complexes - Metabolism | en_US |
dc.subject.mesh | Phospholipases A - Metabolism | en_US |
dc.subject.mesh | Subcellular Fractions - Enzymology | en_US |
dc.title | Mechanism of lysophosphatidylcholine accumulation in the ischemic canine heart | en_US |
dc.type | Article | en_US |
dc.identifier.email | Man, RYK:rykman@hkucc.hku.hk | en_US |
dc.identifier.authority | Man, RYK=rp00236 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/BF02537977 | en_US |
dc.identifier.pmid | 2395414 | - |
dc.identifier.scopus | eid_2-s2.0-0025269871 | en_US |
dc.identifier.volume | 25 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.spage | 357 | en_US |
dc.identifier.epage | 362 | en_US |
dc.identifier.isi | WOS:A1990DP79600001 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Mock, T=35954418100 | en_US |
dc.identifier.scopusauthorid | Man, RYK=7004986435 | en_US |
dc.identifier.issnl | 0024-4201 | - |