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- Publisher Website: 10.1016/0735-1097(91)90854-3
- Scopus: eid_2-s2.0-0025727291
- PMID: 2007721
- WOS: WOS:A1991FF47400033
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Article: Angiographic demonstration of hyperconstriction induced by serotonin and aggregating platelets in porcine coronary arteries with regenerated endothelium
Title | Angiographic demonstration of hyperconstriction induced by serotonin and aggregating platelets in porcine coronary arteries with regenerated endothelium |
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Authors | |
Issue Date | 1991 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jac |
Citation | Journal Of The American College Of Cardiology, 1991, v. 17 n. 5, p. 1197-1202 How to Cite? |
Abstract | In isolated porcine coronary arteries, the endothelium inhibits the ntractions induced by serotonin and aggregating platelets. This effect is reduced by regeneration after balloon denudation. The present study was designed to examine whether those in vitro observations could be reproduced in vivo. Sixteen male Yorkshire pigs underwent balloon removal of the endothelium from either the left anterior descending (n = 9) or left circumflex (n =7) coronary artery. An angiographic study was performed before and 4 weeks after endothelial denudation; in the latter condition the presence of a full endothelial lining was confirmed histologically. Before endothelial denudation, intracoronary injection of serotonin (10 μg/kg) caused only mild constriction in both arteries. However, 4 weeks after the denudation, intracoronary serotonin repeatedly caused marked hyperconstriction in the previously denuded artery compared with the control coronary artery. Intracoronary injection of aggregating platelets stimulated by collagen caused constriction in the previously denuded artery but not in the control artery. The hyperconstriction induced by serotonin and aggregating platelets was inhibited by intravenous injection of ketanserin (a 5-HT2-serotonergic blocker). These data indicate that 1) the normal endothelium blunts the coronary vasoconstriction induced by serotonin and aggregating platelets in vivo, and 2) the inhibitory effect of the endothelium is reduced after regeneration, allowing coronary hyperconstriction or vasospasm, or both. |
Persistent Identifier | http://hdl.handle.net/10722/171001 |
ISSN | 2023 Impact Factor: 21.7 2023 SCImago Journal Rankings: 8.762 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Shimokawa, H | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:47Z | - |
dc.date.available | 2012-10-30T06:11:47Z | - |
dc.date.issued | 1991 | en_US |
dc.identifier.citation | Journal Of The American College Of Cardiology, 1991, v. 17 n. 5, p. 1197-1202 | en_US |
dc.identifier.issn | 0735-1097 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171001 | - |
dc.description.abstract | In isolated porcine coronary arteries, the endothelium inhibits the ntractions induced by serotonin and aggregating platelets. This effect is reduced by regeneration after balloon denudation. The present study was designed to examine whether those in vitro observations could be reproduced in vivo. Sixteen male Yorkshire pigs underwent balloon removal of the endothelium from either the left anterior descending (n = 9) or left circumflex (n =7) coronary artery. An angiographic study was performed before and 4 weeks after endothelial denudation; in the latter condition the presence of a full endothelial lining was confirmed histologically. Before endothelial denudation, intracoronary injection of serotonin (10 μg/kg) caused only mild constriction in both arteries. However, 4 weeks after the denudation, intracoronary serotonin repeatedly caused marked hyperconstriction in the previously denuded artery compared with the control coronary artery. Intracoronary injection of aggregating platelets stimulated by collagen caused constriction in the previously denuded artery but not in the control artery. The hyperconstriction induced by serotonin and aggregating platelets was inhibited by intravenous injection of ketanserin (a 5-HT2-serotonergic blocker). These data indicate that 1) the normal endothelium blunts the coronary vasoconstriction induced by serotonin and aggregating platelets in vivo, and 2) the inhibitory effect of the endothelium is reduced after regeneration, allowing coronary hyperconstriction or vasospasm, or both. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jac | en_US |
dc.relation.ispartof | Journal of the American College of Cardiology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Coronary Angiography | en_US |
dc.subject.mesh | Coronary Vessels - Drug Effects - Physiology | en_US |
dc.subject.mesh | Endothelium, Vascular - Drug Effects - Physiology - Radiography | en_US |
dc.subject.mesh | Ketanserin - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Platelet Aggregation - Physiology | en_US |
dc.subject.mesh | Regeneration - Physiology | en_US |
dc.subject.mesh | Serotonin - Pharmacology | en_US |
dc.subject.mesh | Swine | en_US |
dc.subject.mesh | Vasoconstriction - Drug Effects - Physiology | en_US |
dc.title | Angiographic demonstration of hyperconstriction induced by serotonin and aggregating platelets in porcine coronary arteries with regenerated endothelium | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0735-1097(91)90854-3 | - |
dc.identifier.pmid | 2007721 | - |
dc.identifier.scopus | eid_2-s2.0-0025727291 | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 1197 | en_US |
dc.identifier.epage | 1202 | en_US |
dc.identifier.isi | WOS:A1991FF47400033 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Shimokawa, H=16684837100 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0735-1097 | - |