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- Scopus: eid_2-s2.0-0025944598
- PMID: 1681744
- WOS: WOS:A1991GK86900086
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Article: Progesterone and modulation of endothelium-dependent responses in canine coronary arteries
Title | Progesterone and modulation of endothelium-dependent responses in canine coronary arteries |
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Authors | |
Keywords | acetylcholine adenosine diphosphate BHT-920 calcium ionophore A23187 G proteins guanine nucleotide regulatory proteins hormones nitric oxide steroids thrombin |
Issue Date | 1991 |
Publisher | American Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/ |
Citation | American Journal Of Physiology - Regulatory Integrative And Comparative Physiology, 1991, v. 261 n. 4 30-4, p. R1022-R1027 How to Cite? |
Abstract | Chronic treatment with estrogens enhances some endothelium-dependent relaxations. Whether or not progesterone would exert a similar effect is unknown. Experiments were designed to determine the effect of chronic treatment with progesterone on endothelium-dependent responses. Adult female dogs were ovariectomized and pellets containing carrier substance, estrogen, progesterone, or estrogen plus progesterone were implanted subcutaneously. After 14-21 days coronary arteries were removed, cut into rings, and suspended for the measurement of isometric force in organ chambers in the presence of indomethacin. Endothelium-dependent relaxations to ADP, bradykinin, or the calcium ionophore did not differ among groups. However, relaxations to acetylcholine and to the α2-adrenergic agonist BHT-920 were greater in the estrogen-treated group than in the estrogen plus progesterone-treated group. In rings without endothelium, relaxations to nitric oxide and isoproterenol did not differ among groups. However, relaxations of the smooth muscle to ADP were greater in the progesterone-treated group than in the progesterone plus estrogen group. These results suggest that progesterone alone minimally affects endothelium-dependent responses. However, progesterone seems to antagonize the stimulatory effects of estrogen on two endothelium-dependent responses that are associated with pertussis toxin-sensitive guanine nucleotide regulatory proteins and the production of nitric oxide. These studies suggest that a specific receptor/second messenger system can be modulated by female reproductive steroid hormones. |
Persistent Identifier | http://hdl.handle.net/10722/171016 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Miller, VM | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:50Z | - |
dc.date.available | 2012-10-30T06:11:50Z | - |
dc.date.issued | 1991 | en_US |
dc.identifier.citation | American Journal Of Physiology - Regulatory Integrative And Comparative Physiology, 1991, v. 261 n. 4 30-4, p. R1022-R1027 | en_US |
dc.identifier.issn | 0002-9513 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171016 | - |
dc.description.abstract | Chronic treatment with estrogens enhances some endothelium-dependent relaxations. Whether or not progesterone would exert a similar effect is unknown. Experiments were designed to determine the effect of chronic treatment with progesterone on endothelium-dependent responses. Adult female dogs were ovariectomized and pellets containing carrier substance, estrogen, progesterone, or estrogen plus progesterone were implanted subcutaneously. After 14-21 days coronary arteries were removed, cut into rings, and suspended for the measurement of isometric force in organ chambers in the presence of indomethacin. Endothelium-dependent relaxations to ADP, bradykinin, or the calcium ionophore did not differ among groups. However, relaxations to acetylcholine and to the α2-adrenergic agonist BHT-920 were greater in the estrogen-treated group than in the estrogen plus progesterone-treated group. In rings without endothelium, relaxations to nitric oxide and isoproterenol did not differ among groups. However, relaxations of the smooth muscle to ADP were greater in the progesterone-treated group than in the progesterone plus estrogen group. These results suggest that progesterone alone minimally affects endothelium-dependent responses. However, progesterone seems to antagonize the stimulatory effects of estrogen on two endothelium-dependent responses that are associated with pertussis toxin-sensitive guanine nucleotide regulatory proteins and the production of nitric oxide. These studies suggest that a specific receptor/second messenger system can be modulated by female reproductive steroid hormones. | en_US |
dc.language | eng | en_US |
dc.publisher | American Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/ | en_US |
dc.relation.ispartof | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | en_US |
dc.subject | acetylcholine | - |
dc.subject | adenosine diphosphate | - |
dc.subject | BHT-920 | - |
dc.subject | calcium ionophore A23187 | - |
dc.subject | G proteins | - |
dc.subject | guanine nucleotide regulatory proteins | - |
dc.subject | hormones | - |
dc.subject | nitric oxide | - |
dc.subject | steroids | - |
dc.subject | thrombin | - |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Adenosine Diphosphate - Pharmacology | en_US |
dc.subject.mesh | Adrenergic Alpha-Agonists - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Arteries | en_US |
dc.subject.mesh | Azepines - Pharmacology | en_US |
dc.subject.mesh | Coronary Vessels - Drug Effects - Physiology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Endothelium, Vascular - Physiology | en_US |
dc.subject.mesh | Estrogens - Blood - Pharmacology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Progesterone - Pharmacology | en_US |
dc.subject.mesh | Vasodilation - Drug Effects | en_US |
dc.title | Progesterone and modulation of endothelium-dependent responses in canine coronary arteries | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 1681744 | - |
dc.identifier.scopus | eid_2-s2.0-0025944598 | en_US |
dc.identifier.volume | 261 | en_US |
dc.identifier.issue | 4 30-4 | en_US |
dc.identifier.spage | R1022 | en_US |
dc.identifier.epage | R1027 | en_US |
dc.identifier.isi | WOS:A1991GK86900086 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Miller, VM=7201476816 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0002-9513 | - |