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- Publisher Website: 10.1002/jor.1100100118
- Scopus: eid_2-s2.0-0026546866
- PMID: 1309385
- WOS: WOS:A1992GX48200017
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Article: The effect of hypothermic ischemia on the α-adrenergic mechanisms of the canine tibia vascular bed
Title | The effect of hypothermic ischemia on the α-adrenergic mechanisms of the canine tibia vascular bed |
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Authors | |
Keywords | Canine tibia Ischemia Norepinephrine α‐adrenergic mechanisms |
Issue Date | 1992 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres |
Citation | Journal Of Orthopaedic Research, 1992, v. 10 n. 1, p. 149-155 How to Cite? |
Abstract | The effect of hypothermic ischemia on α-1 and -2 adrenergic receptor mediated vasoconstriction has been studied in an in vitro perfused canine tibia preparation. Bones were perfused at a constant rate with aerated (95% O2, 5% CO2) modified Krebs Ringer solution and the effect of bolus injections of norepinephrine (0.025-6.4 nmol) on the perfusion pressure was studied. For all bones the first dose-response curve was produced under control conditions. In one group the second dose-response curve was generated during a constant infusion of prazosin (α-1 adrenergic antagonist); in another it was produced during a constant infusion of rauwolscine (α-2 adrenergic antagonist); in the control group it was generated under control conditions. The results demonstrate that, after 48 h of hypothermic ischemia, α-1 adrenergic-mediated vasoconstriction was significantly attenuated (p < 0.001). However, α-2 adrenergic-mediated vasoconstriction was unaffected by increasing periods of hypothermic ischemia. | The effect of hypothermic ischemia on α-1 and -2 adrenergic receptor mediated vasoconstriction has been studied in an in vitro perfused canine tibia preparation. Bones were perfused at a constant rate with aerated (95% O2, 5% CO2) modified Krebs Ringer solution and the effect of bolus injections of norepinephrine (0.025-6.4 nmol) on the perfusion pressure was studied. For all bones the first dose-response curve was produced under control conditions. In one group the second dose-response curve was generated during a constant infusion of prazosin (α-1 adrenergic antagonist); in another it was produced during a constant infusion of rauwolscine (α-2 adrenergic antagonist); in the control group it was generated under control conditions. The results demonstrate that, after 48 h of hypothermic ischemia, α-1 adrenergic-mediated vasoconstriction was significantly attenuated (p < 0.001). However, α-2 adrenergic-mediated vasoconstriction was unaffected by increasing periods of hypothermic ischemia. |
Persistent Identifier | http://hdl.handle.net/10722/171050 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.886 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Davis, TRC | en_US |
dc.contributor.author | Wood, MB | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:59Z | - |
dc.date.available | 2012-10-30T06:11:59Z | - |
dc.date.issued | 1992 | en_US |
dc.identifier.citation | Journal Of Orthopaedic Research, 1992, v. 10 n. 1, p. 149-155 | en_US |
dc.identifier.issn | 0736-0266 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171050 | - |
dc.description.abstract | The effect of hypothermic ischemia on α-1 and -2 adrenergic receptor mediated vasoconstriction has been studied in an in vitro perfused canine tibia preparation. Bones were perfused at a constant rate with aerated (95% O2, 5% CO2) modified Krebs Ringer solution and the effect of bolus injections of norepinephrine (0.025-6.4 nmol) on the perfusion pressure was studied. For all bones the first dose-response curve was produced under control conditions. In one group the second dose-response curve was generated during a constant infusion of prazosin (α-1 adrenergic antagonist); in another it was produced during a constant infusion of rauwolscine (α-2 adrenergic antagonist); in the control group it was generated under control conditions. The results demonstrate that, after 48 h of hypothermic ischemia, α-1 adrenergic-mediated vasoconstriction was significantly attenuated (p < 0.001). However, α-2 adrenergic-mediated vasoconstriction was unaffected by increasing periods of hypothermic ischemia. | The effect of hypothermic ischemia on α-1 and -2 adrenergic receptor mediated vasoconstriction has been studied in an in vitro perfused canine tibia preparation. Bones were perfused at a constant rate with aerated (95% O2, 5% CO2) modified Krebs Ringer solution and the effect of bolus injections of norepinephrine (0.025-6.4 nmol) on the perfusion pressure was studied. For all bones the first dose-response curve was produced under control conditions. In one group the second dose-response curve was generated during a constant infusion of prazosin (α-1 adrenergic antagonist); in another it was produced during a constant infusion of rauwolscine (α-2 adrenergic antagonist); in the control group it was generated under control conditions. The results demonstrate that, after 48 h of hypothermic ischemia, α-1 adrenergic-mediated vasoconstriction was significantly attenuated (p < 0.001). However, α-2 adrenergic-mediated vasoconstriction was unaffected by increasing periods of hypothermic ischemia. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres | en_US |
dc.relation.ispartof | Journal of Orthopaedic Research | en_US |
dc.subject | Canine tibia | - |
dc.subject | Ischemia | - |
dc.subject | Norepinephrine | - |
dc.subject | α‐adrenergic mechanisms | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood Vessels - Innervation | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Hypothermia - Physiopathology | en_US |
dc.subject.mesh | Ischemia - Physiopathology | en_US |
dc.subject.mesh | Norepinephrine - Pharmacology | en_US |
dc.subject.mesh | Perfusion | en_US |
dc.subject.mesh | Pressure | en_US |
dc.subject.mesh | Receptors, Adrenergic, Alpha - Physiology | en_US |
dc.subject.mesh | Regional Blood Flow | en_US |
dc.subject.mesh | Tibia - Blood Supply | en_US |
dc.subject.mesh | Yohimbine - Pharmacology | en_US |
dc.title | The effect of hypothermic ischemia on the α-adrenergic mechanisms of the canine tibia vascular bed | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/jor.1100100118 | - |
dc.identifier.pmid | 1309385 | - |
dc.identifier.scopus | eid_2-s2.0-0026546866 | en_US |
dc.identifier.volume | 10 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 149 | en_US |
dc.identifier.epage | 155 | en_US |
dc.identifier.isi | WOS:A1992GX48200017 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Davis, TRC=8642707500 | en_US |
dc.identifier.scopusauthorid | Wood, MB=7403448994 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0736-0266 | - |