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- Scopus: eid_2-s2.0-0026795073
- PMID: 1329532
- WOS: WOS:A1992JP90100084
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Article: Effects of hydrogen peroxide on the responsiveness of isolated canine bronchi: Role of prostaglandin E2 and I2
Title | Effects of hydrogen peroxide on the responsiveness of isolated canine bronchi: Role of prostaglandin E2 and I2 |
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Authors | |
Keywords | adenosine 3',5'-cyclic monophosphate airway smooth muscle epithelium indomethacin methylene blue prostaglandin E2 prostaglandin I2 |
Issue Date | 1992 |
Publisher | American Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/ |
Citation | American Journal Of Physiology - Lung Cellular And Molecular Physiology, 1992, v. 263 n. 3 7-3, p. L402-L408 How to Cite? |
Abstract | The present study was designed to determine the role of prostaglandin E2 and I2 in the responses of isolated canine airways to H2O2. Rings of canine third-order bronchi, some of which had undergone mechanical denudation of the epithelium, were suspended in organ chambers; isometric tension was recorded. During contractions to acetylcholine, H2O2 induced concentration- dependent relaxations. The relaxations were attenuated significantly by indomethacin, acetylsalicylic acid, and methylene blue. H2O2 increased the release of prostaglandin E2 and 6-keto-prostaglandin F(1α) and the content of adenosine 3',5'-cyclic monophosphate (cAMP). These effects were abolished by indomethacin or methylene blue. H2O2 did not affect the content of guanosine 3',5'-cyclic monophosphate significantly. These observations suggest that 1) H2O2 relaxes canine bronchial smooth muscle and 2) elevation of tissue content of cAMP induced by prostaglandin E2 and I2 may be involved. These phenomena did not appear to be modulated by the respiratory epithelium, since H2O2-induced relaxations and increases in the release of PGE2 and 6-ketoprostaglandin F(1α) were similar in preparations with and without epithelium. However, after treatment with methylene blue, H2O2 induced contractions only in preparations with epithelium. These epithelium-dependent contractions were not affected by inhibitors of cyclooxygenase and lipoxygenase. |
Persistent Identifier | http://hdl.handle.net/10722/171075 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Gao, Y | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:12:06Z | - |
dc.date.available | 2012-10-30T06:12:06Z | - |
dc.date.issued | 1992 | en_US |
dc.identifier.citation | American Journal Of Physiology - Lung Cellular And Molecular Physiology, 1992, v. 263 n. 3 7-3, p. L402-L408 | en_US |
dc.identifier.issn | 0002-9513 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171075 | - |
dc.description.abstract | The present study was designed to determine the role of prostaglandin E2 and I2 in the responses of isolated canine airways to H2O2. Rings of canine third-order bronchi, some of which had undergone mechanical denudation of the epithelium, were suspended in organ chambers; isometric tension was recorded. During contractions to acetylcholine, H2O2 induced concentration- dependent relaxations. The relaxations were attenuated significantly by indomethacin, acetylsalicylic acid, and methylene blue. H2O2 increased the release of prostaglandin E2 and 6-keto-prostaglandin F(1α) and the content of adenosine 3',5'-cyclic monophosphate (cAMP). These effects were abolished by indomethacin or methylene blue. H2O2 did not affect the content of guanosine 3',5'-cyclic monophosphate significantly. These observations suggest that 1) H2O2 relaxes canine bronchial smooth muscle and 2) elevation of tissue content of cAMP induced by prostaglandin E2 and I2 may be involved. These phenomena did not appear to be modulated by the respiratory epithelium, since H2O2-induced relaxations and increases in the release of PGE2 and 6-ketoprostaglandin F(1α) were similar in preparations with and without epithelium. However, after treatment with methylene blue, H2O2 induced contractions only in preparations with epithelium. These epithelium-dependent contractions were not affected by inhibitors of cyclooxygenase and lipoxygenase. | en_US |
dc.language | eng | en_US |
dc.publisher | American Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/ | en_US |
dc.relation.ispartof | American Journal of Physiology - Lung Cellular and Molecular Physiology | en_US |
dc.subject | adenosine 3',5'-cyclic monophosphate | - |
dc.subject | airway smooth muscle | - |
dc.subject | epithelium | - |
dc.subject | indomethacin | - |
dc.subject | methylene blue | - |
dc.subject | prostaglandin E2 | - |
dc.subject | prostaglandin I2 | - |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bronchi - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Bronchoconstriction | en_US |
dc.subject.mesh | Cyclic Amp - Metabolism | en_US |
dc.subject.mesh | Cyclic Gmp - Metabolism | en_US |
dc.subject.mesh | Dinoprostone - Physiology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Epoprostenol - Physiology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Hydrogen Peroxide - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.title | Effects of hydrogen peroxide on the responsiveness of isolated canine bronchi: Role of prostaglandin E2 and I2 | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 1329532 | - |
dc.identifier.scopus | eid_2-s2.0-0026795073 | en_US |
dc.identifier.volume | 263 | en_US |
dc.identifier.issue | 3 7-3 | en_US |
dc.identifier.spage | L402 | en_US |
dc.identifier.epage | L408 | en_US |
dc.identifier.isi | WOS:A1992JP90100084 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Gao, Y=7404706442 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0002-9513 | - |