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- Publisher Website: 10.1161/01.HYP.21.3.289
- Scopus: eid_2-s2.0-0027535880
- PMID: 8478037
- WOS: WOS:A1993KQ78900005
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Article: Interleukin-2 causes endothelium-dependent contractions to arachidonic acid
Title | Interleukin-2 causes endothelium-dependent contractions to arachidonic acid |
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Authors | |
Keywords | Aorta Arachidonic acids Endothelium Inbred SHR Inbred WKY Interleukin-2 Prostaglandin endoperoxides Prostaglandin synthase Rats Rats |
Issue Date | 1993 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/ |
Citation | Hypertension, 1993, v. 21 n. 3, p. 289-293 How to Cite? |
Abstract | The present experiments were designed to investigate the effect of interleukin-2 on the response to arachidonic acid in rings with and without endothelium from Wistar-Kyoto (WKY) and spontaneously hypertensive rat (SHR) aortas. In control rings, arachidonic acid induced contractions of WKY aorta that were not different between preparations with and without endothelium. Incubation with interleukin-2 (10 units/mL) for 6 or 18 hours augmented the response to arachidonic acid in rings with, but not in those without, endothelium from WKY rat aortas. In the WKY aorta, both the endothelium- dependent and endothelium-independent contractions to arachidonic acid observed after incubation with interleukin-2 were abolished by indomethacin and ridogrel (a thromboxane-endoperoxide receptor antagonist and a thromboxane synthase inhibitor) but were not affected by dazoxiben (a thromboxane synthase inhibitor). Interleukin-2 did not augment the vascular reactivity of WKY aortic smooth muscle to activation of the thromboxane- endoperoxide receptor with U46619. In aortas from SHRs, arachidonic acid evoked endothelium-dependent contraction; interleukin-2 did not modify the response to arachidonic acid in preparations with and without endothelium. These data demonstrate that 1) endothelium-dependent contractions to arachidonic acid are observed in SHR but not in WKY rat aortas; 2) interleukin-2 induces endothelium-dependent contractions to arachidonic acid in the WKY aorta that are mediated by an augmented release of a metabolite of cyclooxygenase, different from thromboxane A2 but activating thromboxane- endoperoxide receptors; and 3) interleukin-2 does not affect the endothelium- dependent and endothelium-independent response to arachidonic acid in the SHR aorta. |
Persistent Identifier | http://hdl.handle.net/10722/171114 |
ISSN | 2023 Impact Factor: 6.9 2023 SCImago Journal Rankings: 2.827 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Boulanger, CM | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:12:15Z | - |
dc.date.available | 2012-10-30T06:12:15Z | - |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | Hypertension, 1993, v. 21 n. 3, p. 289-293 | en_US |
dc.identifier.issn | 0194-911X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171114 | - |
dc.description.abstract | The present experiments were designed to investigate the effect of interleukin-2 on the response to arachidonic acid in rings with and without endothelium from Wistar-Kyoto (WKY) and spontaneously hypertensive rat (SHR) aortas. In control rings, arachidonic acid induced contractions of WKY aorta that were not different between preparations with and without endothelium. Incubation with interleukin-2 (10 units/mL) for 6 or 18 hours augmented the response to arachidonic acid in rings with, but not in those without, endothelium from WKY rat aortas. In the WKY aorta, both the endothelium- dependent and endothelium-independent contractions to arachidonic acid observed after incubation with interleukin-2 were abolished by indomethacin and ridogrel (a thromboxane-endoperoxide receptor antagonist and a thromboxane synthase inhibitor) but were not affected by dazoxiben (a thromboxane synthase inhibitor). Interleukin-2 did not augment the vascular reactivity of WKY aortic smooth muscle to activation of the thromboxane- endoperoxide receptor with U46619. In aortas from SHRs, arachidonic acid evoked endothelium-dependent contraction; interleukin-2 did not modify the response to arachidonic acid in preparations with and without endothelium. These data demonstrate that 1) endothelium-dependent contractions to arachidonic acid are observed in SHR but not in WKY rat aortas; 2) interleukin-2 induces endothelium-dependent contractions to arachidonic acid in the WKY aorta that are mediated by an augmented release of a metabolite of cyclooxygenase, different from thromboxane A2 but activating thromboxane- endoperoxide receptors; and 3) interleukin-2 does not affect the endothelium- dependent and endothelium-independent response to arachidonic acid in the SHR aorta. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/ | en_US |
dc.relation.ispartof | Hypertension | en_US |
dc.subject | Aorta | - |
dc.subject | Arachidonic acids | - |
dc.subject | Endothelium | - |
dc.subject | Inbred SHR | - |
dc.subject | Inbred WKY | - |
dc.subject | Interleukin-2 | - |
dc.subject | Prostaglandin endoperoxides | - |
dc.subject | Prostaglandin synthase | - |
dc.subject | Rats | - |
dc.subject | Rats | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Aorta - Drug Effects - Physiology | en_US |
dc.subject.mesh | Arachidonic Acid - Metabolism - Pharmacology | en_US |
dc.subject.mesh | Endothelium, Vascular - Physiology | en_US |
dc.subject.mesh | Hypertension - Physiopathology | en_US |
dc.subject.mesh | Interleukin-2 - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Shr | en_US |
dc.subject.mesh | Rats, Inbred Wky | en_US |
dc.subject.mesh | Vasoconstriction - Drug Effects | en_US |
dc.title | Interleukin-2 causes endothelium-dependent contractions to arachidonic acid | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1161/01.HYP.21.3.289 | - |
dc.identifier.pmid | 8478037 | - |
dc.identifier.scopus | eid_2-s2.0-0027535880 | en_US |
dc.identifier.volume | 21 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 289 | en_US |
dc.identifier.epage | 293 | en_US |
dc.identifier.isi | WOS:A1993KQ78900005 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Boulanger, CM=7006599024 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0194-911X | - |