File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Sleep deprivation increase the expression of inducible heat shock protein 70 in rat gastric mucosa

TitleSleep deprivation increase the expression of inducible heat shock protein 70 in rat gastric mucosa
Authors
Issue Date2001
PublisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
Citation
World Journal Of Gastroenterology, 2001, v. 7 n. 4, p. 496-499 How to Cite?
AbstractAim: To investigate if sleep deprivation is able to increase the expression of inducible heat shock protein 70 in gastric mucosa and its possible role in mucosal defense. Methods: Rats for sleep disruption were placed inside a computerized rotating drum, gastric mucosa was taken from rats with 1, 3 and 7 d sleep deprivation. RT-PCR, immunohistochemistry and Western blotting were used to determine the expression of heat shock protein 70. Ethanol (500 mL.L-1, i.g.) was used to induce gastric mucosa damage. Results: RT-PCR, Western blotting and immunostaining confirmed that the sleep deprivation as a stress resulted in significantly greater expression of inducible heat shock protein 70 in gastric mucosa of rats. After the 500mL.L-1 ethanol challenge, the ulcer area found in the rats with 7 d sleep deprivation (19.15 ± 4.2) mm2 was significantly lower (P<0.01) than the corresponding control (53.7 ± 8.1) mm2. Conclusion: Sleep deprivation as a stress, in addition to lowering the gastric mucosal barrier, is able to stimulate the expression of inducible heat shock protein 70 in gastric mucosa of rats, the heat shock protein 70 may play an important role in gastric mucosal protection.
Persistent Identifierhttp://hdl.handle.net/10722/171259
ISSN
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 1.063
References

 

DC FieldValueLanguage
dc.contributor.authorShen, XZen_US
dc.contributor.authorKoo, MWLen_US
dc.contributor.authorCho, CHen_US
dc.date.accessioned2012-10-30T06:13:00Z-
dc.date.available2012-10-30T06:13:00Z-
dc.date.issued2001en_US
dc.identifier.citationWorld Journal Of Gastroenterology, 2001, v. 7 n. 4, p. 496-499en_US
dc.identifier.issn1007-9327en_US
dc.identifier.urihttp://hdl.handle.net/10722/171259-
dc.description.abstractAim: To investigate if sleep deprivation is able to increase the expression of inducible heat shock protein 70 in gastric mucosa and its possible role in mucosal defense. Methods: Rats for sleep disruption were placed inside a computerized rotating drum, gastric mucosa was taken from rats with 1, 3 and 7 d sleep deprivation. RT-PCR, immunohistochemistry and Western blotting were used to determine the expression of heat shock protein 70. Ethanol (500 mL.L-1, i.g.) was used to induce gastric mucosa damage. Results: RT-PCR, Western blotting and immunostaining confirmed that the sleep deprivation as a stress resulted in significantly greater expression of inducible heat shock protein 70 in gastric mucosa of rats. After the 500mL.L-1 ethanol challenge, the ulcer area found in the rats with 7 d sleep deprivation (19.15 ± 4.2) mm2 was significantly lower (P<0.01) than the corresponding control (53.7 ± 8.1) mm2. Conclusion: Sleep deprivation as a stress, in addition to lowering the gastric mucosal barrier, is able to stimulate the expression of inducible heat shock protein 70 in gastric mucosa of rats, the heat shock protein 70 may play an important role in gastric mucosal protection.en_US
dc.languageengen_US
dc.publisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htmen_US
dc.relation.ispartofWorld Journal of Gastroenterologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCentral Nervous System Depressants - Pharmacologyen_US
dc.subject.meshEthanol - Pharmacologyen_US
dc.subject.meshGastric Mucosa - Chemistry - Physiologyen_US
dc.subject.meshGene Expression - Physiologyen_US
dc.subject.meshHsp70 Heat-Shock Proteins - Analysis - Geneticsen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshRna, Messenger - Analysisen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSleep Deprivation - Physiopathologyen_US
dc.subject.meshStomach Ulcer - Chemically Induced - Prevention & Controlen_US
dc.titleSleep deprivation increase the expression of inducible heat shock protein 70 in rat gastric mucosaen_US
dc.typeArticleen_US
dc.identifier.emailKoo, MWL:wlkoo@hku.hken_US
dc.identifier.authorityKoo, MWL=rp00233en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.pmid11819816-
dc.identifier.scopuseid_2-s2.0-0034888769en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034888769&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume7en_US
dc.identifier.issue4en_US
dc.identifier.spage496en_US
dc.identifier.epage499en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridShen, XZ=7402721067en_US
dc.identifier.scopusauthoridKoo, MWL=7004550899en_US
dc.identifier.scopusauthoridCho, CH=7403100461en_US
dc.identifier.issnl1007-9327-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats