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- Publisher Website: 10.1016/j.addr.2011.03.011
- Scopus: eid_2-s2.0-79957768993
- PMID: 21457742
- WOS: WOS:000292537800002
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Article: Production methods for nanodrug particles using the bottom-up approach
Title | Production methods for nanodrug particles using the bottom-up approach |
---|---|
Authors | |
Keywords | Crystallisation Drying Evaporation Hydrosol Micro-mixing Nanoparticle Nanosuspension Particle growth Precipitation Spray |
Issue Date | 2011 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/addr |
Citation | Advanced Drug Delivery Reviews, 2011, v. 63 n. 6, p. 406-416 How to Cite? |
Abstract | This review focuses on bottom-up processes such as precipitation (or crystallisation) and single droplet evaporation to produce nanoparticles containing largely pure therapeutics for pharmaceutical applications. Suitable precipitation techniques involve the use of high-gravity, confined impinging liquid jet mixing, multi-inlet vortex mixing, supercritical fluids, and ultrasonic waves. Droplet evaporation methods are spray-based, including nanospray drying, aerosol flow reactor method, spraying of low-boiling point solvent under ambient conditions and electrospraying of low-electrical conducting solutions. A key to the success of yielding stable nanoparticles in these various techniques is to control the particle growth kinetics through evaporation rate of the droplets or mixing rate during precipitation. © 2011 Elsevier B.V. |
Persistent Identifier | http://hdl.handle.net/10722/171423 |
ISSN | 2023 Impact Factor: 15.2 2023 SCImago Journal Rankings: 3.411 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chan, HK | en_US |
dc.contributor.author | Kwok, PCL | en_US |
dc.date.accessioned | 2012-10-30T06:14:05Z | - |
dc.date.available | 2012-10-30T06:14:05Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Advanced Drug Delivery Reviews, 2011, v. 63 n. 6, p. 406-416 | en_US |
dc.identifier.issn | 0169-409X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171423 | - |
dc.description.abstract | This review focuses on bottom-up processes such as precipitation (or crystallisation) and single droplet evaporation to produce nanoparticles containing largely pure therapeutics for pharmaceutical applications. Suitable precipitation techniques involve the use of high-gravity, confined impinging liquid jet mixing, multi-inlet vortex mixing, supercritical fluids, and ultrasonic waves. Droplet evaporation methods are spray-based, including nanospray drying, aerosol flow reactor method, spraying of low-boiling point solvent under ambient conditions and electrospraying of low-electrical conducting solutions. A key to the success of yielding stable nanoparticles in these various techniques is to control the particle growth kinetics through evaporation rate of the droplets or mixing rate during precipitation. © 2011 Elsevier B.V. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/addr | en_US |
dc.relation.ispartof | Advanced Drug Delivery Reviews | en_US |
dc.subject | Crystallisation | - |
dc.subject | Drying | - |
dc.subject | Evaporation | - |
dc.subject | Hydrosol | - |
dc.subject | Micro-mixing | - |
dc.subject | Nanoparticle | - |
dc.subject | Nanosuspension | - |
dc.subject | Particle growth | - |
dc.subject | Precipitation | - |
dc.subject | Spray | - |
dc.subject.mesh | Crystallization - Methods | en_US |
dc.subject.mesh | Drug Delivery Systems - Methods | en_US |
dc.subject.mesh | Nanoparticles - Administration & Dosage - Chemistry | en_US |
dc.subject.mesh | Nanotechnology - Methods | en_US |
dc.title | Production methods for nanodrug particles using the bottom-up approach | en_US |
dc.type | Article | en_US |
dc.identifier.email | Kwok, PCL:pclkwok@hku.hk | en_US |
dc.identifier.authority | Kwok, PCL=rp01540 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.addr.2011.03.011 | en_US |
dc.identifier.pmid | 21457742 | - |
dc.identifier.scopus | eid_2-s2.0-79957768993 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-79957768993&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 63 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 406 | en_US |
dc.identifier.epage | 416 | en_US |
dc.identifier.isi | WOS:000292537800002 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Chan, HK=7403402677 | en_US |
dc.identifier.scopusauthorid | Kwok, PCL=12646007800 | en_US |
dc.identifier.citeulike | 9125883 | - |
dc.identifier.issnl | 0169-409X | - |