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- Publisher Website: 10.1139/y87-397
- Scopus: eid_2-s2.0-0023607169
- PMID: 2896539
- WOS: WOS:A1987M059300025
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Article: Prejunctional α2-adrenergic properties of S-3341 (dicyclopropylmethyl)amino-2-Δ-2-oxazoline: A comparison with clonidine
Title | Prejunctional α2-adrenergic properties of S-3341 (dicyclopropylmethyl)amino-2-Δ-2-oxazoline: A comparison with clonidine |
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Authors | |
Issue Date | 1987 |
Publisher | N R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjpp |
Citation | Canadian Journal Of Physiology And Pharmacology, 1987, v. 65 n. 12, p. 2496-2499 How to Cite? |
Abstract | The prejunctional activities of S-3341 and clonidine have been studied in the transmural field-stimulated epididymal part of the rat vas deferens. Both S-3341 and clonidine inhibited these neuronally induced contractions. At high concentrations, these agonists induced spontaneous contractions in the preparation, which were abolished by 10-7 M prazosin. The inhibitory effects of S-3341 and clonidine were antagonized in a competitive manner by rauwolscine and were found not to be modified in a statistically significant manner by 10-7 M prazosin. The pA2 values of rauwolscine against S-3341 and clonidine were the same, indicating the receptors influenced by these drugs were the same also. However, the efficacy of S-3341 is lower than that of clonidine (by a factor of approximately 100). This lower efficacy of S-3341 at the prejunctional level could be linked to the lack of a sedative effect of this compound at therapeutic concentrations. |
Persistent Identifier | http://hdl.handle.net/10722/171515 |
ISSN | 2023 Impact Factor: 1.7 2023 SCImago Journal Rankings: 0.499 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bourreau, JP | en_US |
dc.contributor.author | Tricoche, R | en_US |
dc.date.accessioned | 2012-10-30T06:15:30Z | - |
dc.date.available | 2012-10-30T06:15:30Z | - |
dc.date.issued | 1987 | en_US |
dc.identifier.citation | Canadian Journal Of Physiology And Pharmacology, 1987, v. 65 n. 12, p. 2496-2499 | en_US |
dc.identifier.issn | 0008-4212 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171515 | - |
dc.description.abstract | The prejunctional activities of S-3341 and clonidine have been studied in the transmural field-stimulated epididymal part of the rat vas deferens. Both S-3341 and clonidine inhibited these neuronally induced contractions. At high concentrations, these agonists induced spontaneous contractions in the preparation, which were abolished by 10-7 M prazosin. The inhibitory effects of S-3341 and clonidine were antagonized in a competitive manner by rauwolscine and were found not to be modified in a statistically significant manner by 10-7 M prazosin. The pA2 values of rauwolscine against S-3341 and clonidine were the same, indicating the receptors influenced by these drugs were the same also. However, the efficacy of S-3341 is lower than that of clonidine (by a factor of approximately 100). This lower efficacy of S-3341 at the prejunctional level could be linked to the lack of a sedative effect of this compound at therapeutic concentrations. | en_US |
dc.language | eng | en_US |
dc.publisher | N R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjpp | en_US |
dc.relation.ispartof | Canadian Journal of Physiology and Pharmacology | en_US |
dc.subject.mesh | Adrenergic Alpha-Agonists - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Clonidine - Pharmacology | en_US |
dc.subject.mesh | Electric Stimulation | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Muscle Contraction - Drug Effects | en_US |
dc.subject.mesh | Muscle, Smooth - Drug Effects - Innervation | en_US |
dc.subject.mesh | Neuromuscular Junction - Drug Effects | en_US |
dc.subject.mesh | Oxazoles - Pharmacology | en_US |
dc.subject.mesh | Prazosin - Pharmacology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Wky | en_US |
dc.subject.mesh | Vas Deferens - Drug Effects - Innervation - Physiology | en_US |
dc.subject.mesh | Yohimbine - Pharmacology | en_US |
dc.title | Prejunctional α2-adrenergic properties of S-3341 (dicyclopropylmethyl)amino-2-Δ-2-oxazoline: A comparison with clonidine | en_US |
dc.type | Article | en_US |
dc.identifier.email | Bourreau, JP:bourreau@hkucc.hku.hk | en_US |
dc.identifier.authority | Bourreau, JP=rp00389 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1139/y87-397 | - |
dc.identifier.pmid | 2896539 | - |
dc.identifier.scopus | eid_2-s2.0-0023607169 | en_US |
dc.identifier.volume | 65 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.spage | 2496 | en_US |
dc.identifier.epage | 2499 | en_US |
dc.identifier.isi | WOS:A1987M059300025 | - |
dc.publisher.place | Canada | en_US |
dc.identifier.scopusauthorid | Bourreau, JP=7003927886 | en_US |
dc.identifier.scopusauthorid | Tricoche, R=6603907602 | en_US |
dc.identifier.issnl | 0008-4212 | - |