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- Publisher Website: 10.1111/j.1440-1681.1991.tb01474.x
- Scopus: eid_2-s2.0-0025770322
- PMID: 1914245
- WOS: WOS:A1991GA42700007
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Article: Effect of reserpine on catecholamine contents and met-enkephalin and β-endorphin levels in the hypothalamus and the pituitary
Title | Effect of reserpine on catecholamine contents and met-enkephalin and β-endorphin levels in the hypothalamus and the pituitary |
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Authors | |
Keywords | dopamine hypothalamus male rat met‐enkephalin noraphinephrine pituitary reserpine β‐endorphin |
Issue Date | 1991 |
Publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP |
Citation | Clinical And Experimental Pharmacology And Physiology, 1991, v. 18 n. 6, p. 425-429 How to Cite? |
Abstract | 1. The effects of reserpine treatment on the contents of catecholamines and opioid peptides have been studied in the rat hypothalamus and pituitary. 2. Hypothalamic and pituitary catecholamines were drastically depleted following acute reserpine treatment. 3. Reserpine treatment also resulted in a signifiant decrease in immunoactive met-enkephalin content in both the hypothalamus (25%) and the anterior lobe (50%), but not in the neurointermediate lobe of the pituitary. 4. No changes were observed in immunoactive β-endorphin levels. 5. These findings suggest that the met-enkephalin contents in the hypothalamus and the anterior pituitary may be under catecholamine control. 6. The lack of effect of acute reserpine treatment on immunoactive β-endorphin contents might be due to the opposing effects of adrenergic and dopaminergic mechanisms. |
Persistent Identifier | http://hdl.handle.net/10722/171548 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tang, F | en_US |
dc.date.accessioned | 2012-10-30T06:15:37Z | - |
dc.date.available | 2012-10-30T06:15:37Z | - |
dc.date.issued | 1991 | en_US |
dc.identifier.citation | Clinical And Experimental Pharmacology And Physiology, 1991, v. 18 n. 6, p. 425-429 | en_US |
dc.identifier.issn | 0305-1870 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171548 | - |
dc.description.abstract | 1. The effects of reserpine treatment on the contents of catecholamines and opioid peptides have been studied in the rat hypothalamus and pituitary. 2. Hypothalamic and pituitary catecholamines were drastically depleted following acute reserpine treatment. 3. Reserpine treatment also resulted in a signifiant decrease in immunoactive met-enkephalin content in both the hypothalamus (25%) and the anterior lobe (50%), but not in the neurointermediate lobe of the pituitary. 4. No changes were observed in immunoactive β-endorphin levels. 5. These findings suggest that the met-enkephalin contents in the hypothalamus and the anterior pituitary may be under catecholamine control. 6. The lack of effect of acute reserpine treatment on immunoactive β-endorphin contents might be due to the opposing effects of adrenergic and dopaminergic mechanisms. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP | en_US |
dc.relation.ispartof | Clinical and Experimental Pharmacology and Physiology | en_US |
dc.subject | dopamine | - |
dc.subject | hypothalamus | - |
dc.subject | male rat | - |
dc.subject | met‐enkephalin | - |
dc.subject | noraphinephrine | - |
dc.subject | pituitary | - |
dc.subject | reserpine | - |
dc.subject | β‐endorphin | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Catecholamines - Metabolism | en_US |
dc.subject.mesh | Enkephalin, Methionine - Metabolism | en_US |
dc.subject.mesh | Hypothalamus - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Pituitary Gland - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Pituitary Gland, Anterior - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Strains | en_US |
dc.subject.mesh | Reserpine - Pharmacology | en_US |
dc.subject.mesh | Beta-Endorphin - Metabolism | en_US |
dc.title | Effect of reserpine on catecholamine contents and met-enkephalin and β-endorphin levels in the hypothalamus and the pituitary | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tang, F:ftang@hkucc.hku.hk | en_US |
dc.identifier.authority | Tang, F=rp00327 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1440-1681.1991.tb01474.x | - |
dc.identifier.pmid | 1914245 | - |
dc.identifier.scopus | eid_2-s2.0-0025770322 | en_US |
dc.identifier.volume | 18 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 425 | en_US |
dc.identifier.epage | 429 | en_US |
dc.identifier.isi | WOS:A1991GA42700007 | - |
dc.publisher.place | Australia | en_US |
dc.identifier.scopusauthorid | Tang, F=7201979770 | en_US |
dc.identifier.issnl | 0305-1870 | - |