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Article: Ca2+-induced Ca2+ release in sea urchin egg homogenates: Modulation by cyclic ADP-ribose

TitleCa2+-induced Ca2+ release in sea urchin egg homogenates: Modulation by cyclic ADP-ribose
Authors
Galione, ALee, HCBusa, WB
Issue Date1991
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
Citation
Science, 1991, v. 253 n. 5024, p. 1143-1146 How to Cite?
DOI: http://dx.doi.org/10.1126/science.1909457
AbstractCalcium-induced calcium release (CICR) may function widely in calcium-mediated cell signaling, but has been most thoroughly characterized in muscle cells. In a homogenate of sea urchin eggs, which display transients in the intracellular free calcium concentration ([Ca2+]i) during fertilization and anaphase, addition of Ca2+ triggered CICR. Ca2+ release was also induced by the CICR modulators ryanodine and caffeine. Responses to both Ca2+ and CICR modulators (but not Ca2+ release mediated by inositol 1,4,5-trisphosphate) were inhibited by procaine and ruthenium red, inhibitors of CICR. Intact eggs also displayed transients of [Ca2+]i when microinjected with ryanodine. Cyclic ADP-ribose, a metabolite with potent Ca2+-releasing properties, appears to act by way of the CICR mechanism and may thus be an endogenous modulator of CICR. A CICR mechanism is present in these nonmuscle cells as is assumed in various models of intracellular Ca2+ wave propagation.
Persistent Identifierhttp://hdl.handle.net/10722/171564
ISSN
0036-8075
2023 Impact Factor: 44.7
2023 SCImago Journal Rankings: 11.902
ISI Accession Number ID
WOS:A1991GD80800034

 

DC FieldValueLanguage
dc.contributor.authorGalione, Aen_US
dc.contributor.authorLee, HCen_US
dc.contributor.authorBusa, WBen_US
dc.date.accessioned2012-10-30T06:15:42Z-
dc.date.available2012-10-30T06:15:42Z-
dc.date.issued1991en_US
dc.identifier.citationScience, 1991, v. 253 n. 5024, p. 1143-1146en_US
dc.identifier.issn0036-8075en_US
dc.identifier.urihttp://hdl.handle.net/10722/171564-
dc.description.abstractCalcium-induced calcium release (CICR) may function widely in calcium-mediated cell signaling, but has been most thoroughly characterized in muscle cells. In a homogenate of sea urchin eggs, which display transients in the intracellular free calcium concentration ([Ca2+]i) during fertilization and anaphase, addition of Ca2+ triggered CICR. Ca2+ release was also induced by the CICR modulators ryanodine and caffeine. Responses to both Ca2+ and CICR modulators (but not Ca2+ release mediated by inositol 1,4,5-trisphosphate) were inhibited by procaine and ruthenium red, inhibitors of CICR. Intact eggs also displayed transients of [Ca2+]i when microinjected with ryanodine. Cyclic ADP-ribose, a metabolite with potent Ca2+-releasing properties, appears to act by way of the CICR mechanism and may thus be an endogenous modulator of CICR. A CICR mechanism is present in these nonmuscle cells as is assumed in various models of intracellular Ca2+ wave propagation.en_US
dc.languageengen_US
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.orgen_US
dc.relation.ispartofScienceen_US
dc.subject.meshAdenosine Diphosphate Ribose - Pharmacologyen_US
dc.subject.meshAdenosine Triphosphate - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Metabolism - Pharmacologyen_US
dc.subject.meshCyclic Adp-Riboseen_US
dc.subject.meshEgtazic Acid - Pharmacologyen_US
dc.subject.meshKineticsen_US
dc.subject.meshOvum - Drug Effects - Physiologyen_US
dc.subject.meshSea Urchinsen_US
dc.subject.meshSpectrometry, Fluorescenceen_US
dc.subject.meshTime Factorsen_US
dc.titleCa2+-induced Ca2+ release in sea urchin egg homogenates: Modulation by cyclic ADP-riboseen_US
dc.typeArticleen_US
dc.identifier.emailLee, HC:leehc@hku.hken_US
dc.identifier.authorityLee, HC=rp00545en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1126/science.1909457-
dc.identifier.pmid1909457en_US
dc.identifier.scopuseid_2-s2.0-0026418298en_US
dc.identifier.volume253en_US
dc.identifier.issue5024en_US
dc.identifier.spage1143en_US
dc.identifier.epage1146en_US
dc.identifier.isiWOS:A1991GD80800034-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGalione, A=7006334937en_US
dc.identifier.scopusauthoridLee, HC=26642959100en_US
dc.identifier.scopusauthoridBusa, WB=6603916520en_US
dc.identifier.issnl0036-8075-

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