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- Publisher Website: 10.1007/BF00928466
- Scopus: eid_2-s2.0-0028036438
- PMID: 7898468
- WOS: WOS:A1994PU05200030
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Article: Cyclic ADP-ribose: A calcium mobilizing metabolite of NAD+
Title | Cyclic ADP-ribose: A calcium mobilizing metabolite of NAD+ |
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Authors | |
Keywords | ADP-ribosyl cyclase Ca+2 mobilization Ca+2-induced Ca+2 release CD38 cyclic ADP-ribose cyclic ADP-ribose hydrolase cyclic ADP-ribose receptor inositol 1,4,5-trisphosphate ryanodine receptor |
Issue Date | 1994 |
Publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177 |
Citation | Molecular And Cellular Biochemistry, 1994, v. 138 n. 1-2, p. 229-235 How to Cite? |
Abstract | Mobilization of Ca+2 from intracellular stores is a signalling mechanism that is of fundamental importance to many cellular processes. It is mediated by two major mechanisms, the inositol 1,4,5-trisphosphate pathway and the Ca+2-induced Ca+2 release process. A naturally occurring metabolite of NAD+ called cyclic ADP-ribose has been discovered recently and shown to be as effective as inositol 1,4,5-trisphosphate in mobilizing Ca+2 stores in sea urchin eggs, a marine invertebrate cell, as well as several mammalian cells. This article reviews the accumulating evidence that indicates cyclic ADP-ribose may function as a physiological regulator of the Ca+2-induced Ca+2 release process and the current knowledge about its receptor as well as the enzymes involved in its metabolism. |
Persistent Identifier | http://hdl.handle.net/10722/171601 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 0.901 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Hon Cheung Lee | en_US |
dc.date.accessioned | 2012-10-30T06:15:55Z | - |
dc.date.available | 2012-10-30T06:15:55Z | - |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | Molecular And Cellular Biochemistry, 1994, v. 138 n. 1-2, p. 229-235 | en_US |
dc.identifier.issn | 0300-8177 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171601 | - |
dc.description.abstract | Mobilization of Ca+2 from intracellular stores is a signalling mechanism that is of fundamental importance to many cellular processes. It is mediated by two major mechanisms, the inositol 1,4,5-trisphosphate pathway and the Ca+2-induced Ca+2 release process. A naturally occurring metabolite of NAD+ called cyclic ADP-ribose has been discovered recently and shown to be as effective as inositol 1,4,5-trisphosphate in mobilizing Ca+2 stores in sea urchin eggs, a marine invertebrate cell, as well as several mammalian cells. This article reviews the accumulating evidence that indicates cyclic ADP-ribose may function as a physiological regulator of the Ca+2-induced Ca+2 release process and the current knowledge about its receptor as well as the enzymes involved in its metabolism. | en_US |
dc.language | eng | en_US |
dc.publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177 | en_US |
dc.relation.ispartof | Molecular and Cellular Biochemistry | en_US |
dc.subject | ADP-ribosyl cyclase | - |
dc.subject | Ca+2 mobilization | - |
dc.subject | Ca+2-induced Ca+2 release | - |
dc.subject | CD38 | - |
dc.subject | cyclic ADP-ribose | - |
dc.subject | cyclic ADP-ribose hydrolase | - |
dc.subject | cyclic ADP-ribose receptor | - |
dc.subject | inositol 1,4,5-trisphosphate | - |
dc.subject | ryanodine receptor | - |
dc.subject.mesh | Adp-Ribosyl Cyclase | en_US |
dc.subject.mesh | Adenosine Diphosphate Ribose - Analogs & Derivatives - Antagonists & Inhibitors - Physiology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Antigens, Cd | en_US |
dc.subject.mesh | Antigens, Cd38 | en_US |
dc.subject.mesh | Antigens, Differentiation - Metabolism | en_US |
dc.subject.mesh | Calcium - Metabolism | en_US |
dc.subject.mesh | Cyclic Adp-Ribose | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Membrane Glycoproteins | en_US |
dc.subject.mesh | Molecular Structure | en_US |
dc.subject.mesh | N-Glycosyl Hydrolases - Metabolism | en_US |
dc.subject.mesh | Nad - Metabolism | en_US |
dc.subject.mesh | Receptors, Cell Surface - Metabolism | en_US |
dc.title | Cyclic ADP-ribose: A calcium mobilizing metabolite of NAD+ | en_US |
dc.type | Article | en_US |
dc.identifier.email | Hon Cheung Lee:leehc@hku.hk | en_US |
dc.identifier.authority | Hon Cheung Lee=rp00545 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/BF00928466 | en_US |
dc.identifier.pmid | 7898468 | - |
dc.identifier.scopus | eid_2-s2.0-0028036438 | en_US |
dc.identifier.volume | 138 | en_US |
dc.identifier.issue | 1-2 | en_US |
dc.identifier.spage | 229 | en_US |
dc.identifier.epage | 235 | en_US |
dc.identifier.isi | WOS:A1994PU05200030 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Hon Cheung Lee=26642959100 | en_US |
dc.identifier.issnl | 0300-8177 | - |