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- Publisher Website: 10.1016/0034-5687(94)90125-2
- Scopus: eid_2-s2.0-0028281587
- PMID: 7914709
- WOS: WOS:A1994NH83600006
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Article: Involvement of pontile NMDA receptors in inspiratory termination in rat
Title | Involvement of pontile NMDA receptors in inspiratory termination in rat |
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Authors | |
Keywords | control of breathing, NMDA receptors Mammals, rat Mediators, NMDA Pattern of breathing, inspiratory off-switch Pharmacologica agents, CNQX, DNQX, Kainic acid, NMDA agonists, MK-801, AP-5 Receptors, NMDA, pons |
Issue Date | 1994 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/resphysiol |
Citation | Respiration Physiology, 1994, v. 96 n. 2-3, p. 177-188 How to Cite? |
Abstract | We evaluated the hypothesis that N-methyl-D-aspartate (NMDA) receptors in the rostral pons mediate the off-switch of inspiration in the adult rat. Experiments were performed on decerebrate, vagotomized, paralyzed and ventilated animals. Activity of phrenic nerve was recorded. Small volumes (10 nl) of NMDA antagonists, MK-801 and AP-5, or non-NMDA antagonists, CNQX and DNQX, were injected into the rostral pons. We found that injections of MK-801 reversibly increased the duration of neural inspiration (TI), and the increase was dose-dependent. Injections of AP-5 also increased TI. Injections of the DNQX and CNQX in these same loci resulted in no significant changes in the duration of neural inspiration, expiration or peak phrenic activity (PNA). However, injections of kainic acid (KA, 4.7 mM) in the loci increased TI and decreased PNA. We conclude that neurons regulating the off-switch mechanism are located in the rostral pons. Further, the binding of NMDA receptors in the rostral pons is involved in this off-switch mechanism. |
Persistent Identifier | http://hdl.handle.net/10722/171608 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Fung, ML | en_US |
dc.contributor.author | Wang, W | en_US |
dc.contributor.author | St John, WM | en_US |
dc.date.accessioned | 2012-10-30T06:15:57Z | - |
dc.date.available | 2012-10-30T06:15:57Z | - |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | Respiration Physiology, 1994, v. 96 n. 2-3, p. 177-188 | en_US |
dc.identifier.issn | 0034-5687 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171608 | - |
dc.description.abstract | We evaluated the hypothesis that N-methyl-D-aspartate (NMDA) receptors in the rostral pons mediate the off-switch of inspiration in the adult rat. Experiments were performed on decerebrate, vagotomized, paralyzed and ventilated animals. Activity of phrenic nerve was recorded. Small volumes (10 nl) of NMDA antagonists, MK-801 and AP-5, or non-NMDA antagonists, CNQX and DNQX, were injected into the rostral pons. We found that injections of MK-801 reversibly increased the duration of neural inspiration (TI), and the increase was dose-dependent. Injections of AP-5 also increased TI. Injections of the DNQX and CNQX in these same loci resulted in no significant changes in the duration of neural inspiration, expiration or peak phrenic activity (PNA). However, injections of kainic acid (KA, 4.7 mM) in the loci increased TI and decreased PNA. We conclude that neurons regulating the off-switch mechanism are located in the rostral pons. Further, the binding of NMDA receptors in the rostral pons is involved in this off-switch mechanism. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/resphysiol | en_US |
dc.relation.ispartof | Respiration Physiology | en_US |
dc.subject | control of breathing, NMDA receptors | - |
dc.subject | Mammals, rat | - |
dc.subject | Mediators, NMDA | - |
dc.subject | Pattern of breathing, inspiratory off-switch | - |
dc.subject | Pharmacologica agents, CNQX, DNQX, Kainic acid, NMDA agonists, MK-801, AP-5 | - |
dc.subject | Receptors, NMDA, pons | - |
dc.subject.mesh | 2-Amino-5-Phosphonovalerate - Pharmacology | en_US |
dc.subject.mesh | 6-Cyano-7-Nitroquinoxaline-2,3-Dione | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Dizocilpine Maleate - Pharmacology | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Pons - Metabolism | en_US |
dc.subject.mesh | Quinoxalines - Pharmacology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Receptors, N-Methyl-D-Aspartate - Physiology | en_US |
dc.subject.mesh | Respiration - Drug Effects - Physiology | en_US |
dc.title | Involvement of pontile NMDA receptors in inspiratory termination in rat | en_US |
dc.type | Article | en_US |
dc.identifier.email | Fung, ML:fungml@hkucc.hku.hk | en_US |
dc.identifier.authority | Fung, ML=rp00433 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0034-5687(94)90125-2 | - |
dc.identifier.pmid | 7914709 | en_US |
dc.identifier.scopus | eid_2-s2.0-0028281587 | en_US |
dc.identifier.volume | 96 | en_US |
dc.identifier.issue | 2-3 | en_US |
dc.identifier.spage | 177 | en_US |
dc.identifier.epage | 188 | en_US |
dc.identifier.isi | WOS:A1994NH83600006 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Fung, ML=7101955092 | en_US |
dc.identifier.scopusauthorid | Wang, W=7501756233 | en_US |
dc.identifier.scopusauthorid | St John, WM=36831054200 | en_US |
dc.identifier.issnl | 0034-5687 | - |