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- Publisher Website: 10.1016/0278-5846(95)00234-0
- Scopus: eid_2-s2.0-0029416918
- PMID: 8787040
- WOS: WOS:A1995TJ18000005
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Article: The effect of haloperidol on met-enkaphalin, beta-endorphin, cholecystokinin and substance P in the pituitary, the hypothalamus and the striatum of rats during aging
Title | The effect of haloperidol on met-enkaphalin, beta-endorphin, cholecystokinin and substance P in the pituitary, the hypothalamus and the striatum of rats during aging |
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Authors | |
Keywords | Cholecystokinin dopamine haloperidol met-enkephalin substance P β-endorphin |
Issue Date | 1995 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pnpbp |
Citation | Progress In Neuro-Psychopharmacology And Biological Psychiatry, 1995, v. 19 n. 7, p. 1163-1175 How to Cite? |
Abstract | Haloperidol increased the Met-enk level in the striatum at all age groups. However, the Met-enk level was decreased in AL of young and middle-aged rats by the drug. Haloperidol elevated the β-end level in AL and CCK level in NIL in young rats only. The SP content in NIL was decreased by haloperidol in all age groups. With regard to the effect of aging, Met-enk level in AL of middle-aged rats was higher than that in young rats. The β-end level in AL also increased in old rats. Aging modified the haloperidol effect on β-end level in AL and CCK level in NIL as the effect was only observed in young rats. In addition, aging caused a blunted response of Met-enk level to haloperidol in the striatum but an increased response of SP content to haloperidol in the NIL. |
Persistent Identifier | http://hdl.handle.net/10722/171623 |
ISSN | 2023 Impact Factor: 5.3 2023 SCImago Journal Rankings: 1.652 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lau, SM | en_US |
dc.contributor.author | Tang, F | en_US |
dc.date.accessioned | 2012-10-30T06:16:01Z | - |
dc.date.available | 2012-10-30T06:16:01Z | - |
dc.date.issued | 1995 | en_US |
dc.identifier.citation | Progress In Neuro-Psychopharmacology And Biological Psychiatry, 1995, v. 19 n. 7, p. 1163-1175 | en_US |
dc.identifier.issn | 0278-5846 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171623 | - |
dc.description.abstract | Haloperidol increased the Met-enk level in the striatum at all age groups. However, the Met-enk level was decreased in AL of young and middle-aged rats by the drug. Haloperidol elevated the β-end level in AL and CCK level in NIL in young rats only. The SP content in NIL was decreased by haloperidol in all age groups. With regard to the effect of aging, Met-enk level in AL of middle-aged rats was higher than that in young rats. The β-end level in AL also increased in old rats. Aging modified the haloperidol effect on β-end level in AL and CCK level in NIL as the effect was only observed in young rats. In addition, aging caused a blunted response of Met-enk level to haloperidol in the striatum but an increased response of SP content to haloperidol in the NIL. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pnpbp | en_US |
dc.relation.ispartof | Progress in Neuro-Psychopharmacology and Biological Psychiatry | en_US |
dc.rights | Progress in Neuro-Psychopharmacology & Biological Psychiatry. Copyright © Elsevier Inc. | - |
dc.subject | Cholecystokinin | - |
dc.subject | dopamine | - |
dc.subject | haloperidol | - |
dc.subject | met-enkephalin | - |
dc.subject | substance P | - |
dc.subject | β-endorphin | - |
dc.subject.mesh | Aging - Metabolism | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cholecystokinin - Drug Effects | en_US |
dc.subject.mesh | Corpus Striatum - Drug Effects | en_US |
dc.subject.mesh | Enkephalin, Methionine - Drug Effects | en_US |
dc.subject.mesh | Haloperidol - Pharmacology | en_US |
dc.subject.mesh | Hypothalamus - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Pituitary Gland - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Radioimmunoassay | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Substance P - Drug Effects | en_US |
dc.subject.mesh | Beta-Endorphin - Drug Effects | en_US |
dc.title | The effect of haloperidol on met-enkaphalin, beta-endorphin, cholecystokinin and substance P in the pituitary, the hypothalamus and the striatum of rats during aging | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tang, F:ftang@hkucc.hku.hk | en_US |
dc.identifier.authority | Tang, F=rp00327 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0278-5846(95)00234-0 | en_US |
dc.identifier.pmid | 8787040 | - |
dc.identifier.scopus | eid_2-s2.0-0029416918 | en_US |
dc.identifier.hkuros | 11678 | - |
dc.identifier.volume | 19 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.spage | 1163 | en_US |
dc.identifier.epage | 1175 | en_US |
dc.identifier.isi | WOS:A1995TJ18000005 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lau, SM=16740565000 | en_US |
dc.identifier.scopusauthorid | Tang, F=7201979770 | en_US |
dc.identifier.issnl | 0278-5846 | - |