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- Publisher Website: 10.1016/0304-3940(95)12226-5
- Scopus: eid_2-s2.0-0030068351
- PMID: 8848252
- WOS: WOS:A1996TT17000002
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Article: Effects of kainic acid administered to the caudal ventrolateral medulla on arterial blood pressure in the spontaneously hypertensive and normotensive Wistar-Kyoto rats
Title | Effects of kainic acid administered to the caudal ventrolateral medulla on arterial blood pressure in the spontaneously hypertensive and normotensive Wistar-Kyoto rats |
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Authors | |
Keywords | Arterial blood pressure Caudal ventrolateral medulla Kainic acid Spontaneously hypertensive rat Wistar-Kyoto rat |
Issue Date | 1996 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet |
Citation | Neuroscience Letters, 1996, v. 202 n. 3, p. 145-148 How to Cite? |
Abstract | To compare the inhibitory influence of the caudal ventrolateral medulla (RVLM) on rostral ventrolateral medulla (RVLM) between spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WKY) rats, we studied the blood pressure responses to administration of kainic acid, an excitotoxic agent, to CVLM. Unilateral or bilateral administration of kainic acid led to an initial reduction in blood pressure in both types of rats. In SH rats, this was followed by a gradual and sustained presser response. This biphasic response in arterial blood pressure was observed in only one-third of the WKY rats. The elevation in blood pressure was significantly greater in SH than in WKY rats. The finding suggests that the tonic inhibitory influence from RVLM to RVLM may be greater in SH than in WKY rats. |
Persistent Identifier | http://hdl.handle.net/10722/171632 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.745 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Z | en_US |
dc.contributor.author | Chan, YS | en_US |
dc.contributor.author | Wong, TM | en_US |
dc.date.accessioned | 2012-10-30T06:16:04Z | - |
dc.date.available | 2012-10-30T06:16:04Z | - |
dc.date.issued | 1996 | en_US |
dc.identifier.citation | Neuroscience Letters, 1996, v. 202 n. 3, p. 145-148 | en_US |
dc.identifier.issn | 0304-3940 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171632 | - |
dc.description.abstract | To compare the inhibitory influence of the caudal ventrolateral medulla (RVLM) on rostral ventrolateral medulla (RVLM) between spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WKY) rats, we studied the blood pressure responses to administration of kainic acid, an excitotoxic agent, to CVLM. Unilateral or bilateral administration of kainic acid led to an initial reduction in blood pressure in both types of rats. In SH rats, this was followed by a gradual and sustained presser response. This biphasic response in arterial blood pressure was observed in only one-third of the WKY rats. The elevation in blood pressure was significantly greater in SH than in WKY rats. The finding suggests that the tonic inhibitory influence from RVLM to RVLM may be greater in SH than in WKY rats. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet | en_US |
dc.relation.ispartof | Neuroscience Letters | en_US |
dc.rights | Neuroscience Letters. Copyright © Elsevier Ireland Ltd. | - |
dc.subject | Arterial blood pressure | - |
dc.subject | Caudal ventrolateral medulla | - |
dc.subject | Kainic acid | - |
dc.subject | Spontaneously hypertensive rat | - |
dc.subject | Wistar-Kyoto rat | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood Pressure - Drug Effects | en_US |
dc.subject.mesh | Electrodes, Implanted | en_US |
dc.subject.mesh | Excitatory Amino Acid Agonists - Administration & Dosage - Pharmacology | en_US |
dc.subject.mesh | Kainic Acid - Administration & Dosage - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Medulla Oblongata - Anatomy & Histology - Physiology | en_US |
dc.subject.mesh | Microinjections | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Shr | en_US |
dc.subject.mesh | Rats, Inbred Wky | en_US |
dc.title | Effects of kainic acid administered to the caudal ventrolateral medulla on arterial blood pressure in the spontaneously hypertensive and normotensive Wistar-Kyoto rats | en_US |
dc.type | Article | en_US |
dc.identifier.email | Chan, YS:yschan@hkucc.hku.hk | en_US |
dc.identifier.authority | Chan, YS=rp00318 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0304-3940(95)12226-5 | en_US |
dc.identifier.pmid | 8848252 | - |
dc.identifier.scopus | eid_2-s2.0-0030068351 | en_US |
dc.identifier.hkuros | 15430 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0030068351&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 202 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 145 | en_US |
dc.identifier.epage | 148 | en_US |
dc.identifier.isi | WOS:A1996TT17000002 | - |
dc.publisher.place | Ireland | en_US |
dc.identifier.scopusauthorid | Yang, Z=16742980200 | en_US |
dc.identifier.scopusauthorid | Chan, YS=7403676627 | en_US |
dc.identifier.scopusauthorid | Wong, TM=7403531434 | en_US |
dc.identifier.issnl | 0304-3940 | - |