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Article: Alterations of mRNA levels of α1-adrenoceptor subtypes with maturation and ageing in different rat blood vessels

TitleAlterations of mRNA levels of α1-adrenoceptor subtypes with maturation and ageing in different rat blood vessels
Authors
Xu, KMTang, FHan, C
Keywordsageing
blood vessels
development
maturation
receptor regulation
receptor subtypes
senescence
α1-adrenoceptor
Issue Date1997
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP
Citation
Clinical And Experimental Pharmacology And Physiology, 1997, v. 24 n. 6, p. 415-417 How to Cite?
DOI: http://dx.doi.org/10.1111/j.1440-1681.1997.tb01211.x
Abstract1. Alterations of mRNA levels of α1-adrenoceptor subtypes during maturation and ageing were determined by reverse transcription-polymerase chain reaction (RT-PCR) in aortae and renal, pulmonary and mesenteric arteries isolated from 3, 12 and 24-month-old rats. 2. The steady state levels for α(1A)-, α(1B)- and α(1D)-adrenoceptors in aorta declined with maturation and ageing. In renal artery there was a decrease in mRNA for the α(1B)-adrenoceptor in aged rats. However, in mesenteric and pulmonary arteries there were no changes in mRNA levels for the three subtypes of α1- adrenoceptors as a result of maturation and ageing. 3. The results suggest that expression of α1-adrenoceptors is changed heterogeneously in different blood vessels during maturation and ageing in rats.
Persistent Identifierhttp://hdl.handle.net/10722/171639
ISSN
0305-1870
2023 Impact Factor: 2.4
2023 SCImago Journal Rankings: 0.610
ISI Accession Number ID
WOS:A1997XB01800006
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorXu, KMen_US
dc.contributor.authorTang, Fen_US
dc.contributor.authorHan, Cen_US
dc.date.accessioned2012-10-30T06:16:06Z-
dc.date.available2012-10-30T06:16:06Z-
dc.date.issued1997en_US
dc.identifier.citationClinical And Experimental Pharmacology And Physiology, 1997, v. 24 n. 6, p. 415-417en_US
dc.identifier.issn0305-1870en_US
dc.identifier.urihttp://hdl.handle.net/10722/171639-
dc.description.abstract1. Alterations of mRNA levels of α1-adrenoceptor subtypes during maturation and ageing were determined by reverse transcription-polymerase chain reaction (RT-PCR) in aortae and renal, pulmonary and mesenteric arteries isolated from 3, 12 and 24-month-old rats. 2. The steady state levels for α(1A)-, α(1B)- and α(1D)-adrenoceptors in aorta declined with maturation and ageing. In renal artery there was a decrease in mRNA for the α(1B)-adrenoceptor in aged rats. However, in mesenteric and pulmonary arteries there were no changes in mRNA levels for the three subtypes of α1- adrenoceptors as a result of maturation and ageing. 3. The results suggest that expression of α1-adrenoceptors is changed heterogeneously in different blood vessels during maturation and ageing in rats.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEPen_US
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_US
dc.subjectageing-
dc.subjectblood vessels-
dc.subjectdevelopment-
dc.subjectmaturation-
dc.subjectreceptor regulation-
dc.subjectreceptor subtypes-
dc.subjectsenescence-
dc.subjectα1-adrenoceptor-
dc.subject.meshAging - Metabolism - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAorta, Thoracic - Growth & Development - Metabolismen_US
dc.subject.meshArteries - Growth & Development - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMesenteric Arteries - Growth & Development - Metabolismen_US
dc.subject.meshPulmonary Artery - Growth & Development - Metabolismen_US
dc.subject.meshRna, Messenger - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshReceptors, Adrenergic, Alpha-1 - Classification - Genetics - Metabolismen_US
dc.subject.meshRenal Artery - Growth & Development - Metabolismen_US
dc.titleAlterations of mRNA levels of α1-adrenoceptor subtypes with maturation and ageing in different rat blood vesselsen_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1440-1681.1997.tb01211.x-
dc.identifier.pmid9171945-
dc.identifier.scopuseid_2-s2.0-0030985201en_US
dc.identifier.hkuros36596-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030985201&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume24en_US
dc.identifier.issue6en_US
dc.identifier.spage415en_US
dc.identifier.epage417en_US
dc.identifier.isiWOS:A1997XB01800006-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridXu, KM=7403281968en_US
dc.identifier.scopusauthoridTang, F=7201979770en_US
dc.identifier.scopusauthoridHan, C=7403379449en_US
dc.identifier.issnl0305-1870-

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