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- Publisher Website: 10.1016/S0304-3940(99)00728-4
- Scopus: eid_2-s2.0-0032828805
- PMID: 10554980
- WOS: WOS:000083392000011
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Article: Sodium homeostasis in rat hippocampal slices during oxygen and glucose deprivation: Role of voltage-sensitive sodium channels
Title | Sodium homeostasis in rat hippocampal slices during oxygen and glucose deprivation: Role of voltage-sensitive sodium channels |
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Authors | |
Keywords | Anoxic depolarization CA1 Energy deprivation Extracellular sodium ions Hypoglycemia |
Issue Date | 1999 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet |
Citation | Neuroscience Letters, 1999, v. 275 n. 1, p. 41-44 How to Cite? |
Abstract | The breakdown in brain ionic homeostasis during energy deprivation (anoxic depolarization [AD]) is intimately linked to neuronal injury. We studied the role of one particular route of Na + influx, voltage-sensitive Na + channels, in the AD induced by O 2 and/or glucose deprivation. We recorded extracellular Na + concentration ([Na +](e)) and direct current potential (DCP) in the CA1 stratum pyramidale of hippocampal slices using Na +-selective microelectrodes. Tetrodotoxin (0.1-1 μM) delayed the occurrence of AD and reduced the peak change in both [Na +](e) and DCP during AD. However the tetrodotoxin effects were overcome by a concomitant reduction in extracellular glucose during anoxia. We conclude that: (1) the activation of voltage-gated Na + channels is involved in the triggering of AD; (2) there may be a critical level of energy depletion when AD occurs and different mechanisms may underlie AD during hypoxia, compared to O 2 and glucose deprivation. Copyright (C) 1999 Elsevier Science Ireland Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/171664 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.745 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Fung, ML | en_US |
dc.contributor.author | Croning, MDR | en_US |
dc.contributor.author | Haddad, GG | en_US |
dc.date.accessioned | 2012-10-30T06:16:14Z | - |
dc.date.available | 2012-10-30T06:16:14Z | - |
dc.date.issued | 1999 | en_US |
dc.identifier.citation | Neuroscience Letters, 1999, v. 275 n. 1, p. 41-44 | en_US |
dc.identifier.issn | 0304-3940 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171664 | - |
dc.description.abstract | The breakdown in brain ionic homeostasis during energy deprivation (anoxic depolarization [AD]) is intimately linked to neuronal injury. We studied the role of one particular route of Na + influx, voltage-sensitive Na + channels, in the AD induced by O 2 and/or glucose deprivation. We recorded extracellular Na + concentration ([Na +](e)) and direct current potential (DCP) in the CA1 stratum pyramidale of hippocampal slices using Na +-selective microelectrodes. Tetrodotoxin (0.1-1 μM) delayed the occurrence of AD and reduced the peak change in both [Na +](e) and DCP during AD. However the tetrodotoxin effects were overcome by a concomitant reduction in extracellular glucose during anoxia. We conclude that: (1) the activation of voltage-gated Na + channels is involved in the triggering of AD; (2) there may be a critical level of energy depletion when AD occurs and different mechanisms may underlie AD during hypoxia, compared to O 2 and glucose deprivation. Copyright (C) 1999 Elsevier Science Ireland Ltd. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet | en_US |
dc.relation.ispartof | Neuroscience Letters | en_US |
dc.subject | Anoxic depolarization | - |
dc.subject | CA1 | - |
dc.subject | Energy deprivation | - |
dc.subject | Extracellular sodium ions | - |
dc.subject | Hypoglycemia | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cell Hypoxia | en_US |
dc.subject.mesh | Evoked Potentials | en_US |
dc.subject.mesh | Glucose - Deficiency | en_US |
dc.subject.mesh | Hippocampus - Metabolism - Physiology | en_US |
dc.subject.mesh | Homeostasis | en_US |
dc.subject.mesh | Ion Channel Gating | en_US |
dc.subject.mesh | Microelectrodes | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Sodium - Metabolism | en_US |
dc.subject.mesh | Sodium Channels - Drug Effects - Metabolism - Physiology | en_US |
dc.subject.mesh | Tetrodotoxin - Pharmacology | en_US |
dc.title | Sodium homeostasis in rat hippocampal slices during oxygen and glucose deprivation: Role of voltage-sensitive sodium channels | en_US |
dc.type | Article | en_US |
dc.identifier.email | Fung, ML:fungml@hkucc.hku.hk | en_US |
dc.identifier.authority | Fung, ML=rp00433 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/S0304-3940(99)00728-4 | en_US |
dc.identifier.pmid | 10554980 | - |
dc.identifier.scopus | eid_2-s2.0-0032828805 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0032828805&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 275 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 41 | en_US |
dc.identifier.epage | 44 | en_US |
dc.identifier.isi | WOS:000083392000011 | - |
dc.publisher.place | Ireland | en_US |
dc.identifier.scopusauthorid | Fung, ML=7101955092 | en_US |
dc.identifier.scopusauthorid | Croning, MDR=6603151438 | en_US |
dc.identifier.scopusauthorid | Haddad, GG=7201349499 | en_US |
dc.identifier.issnl | 0304-3940 | - |