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Article: The effect of age on the response of the rat brains to continuous β-amyloid infusion

TitleThe effect of age on the response of the rat brains to continuous β-amyloid infusion
Authors
Nag, STang, F
Keywordsβ-Amyloid
Aging
Choline acetyltransferase
Memory
Somatostatin
Issue Date2001
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2001, v. 889 n. 1-2, p. 303-307 How to Cite?
DOI: http://dx.doi.org/10.1016/S0006-8993(00)03172-3
AbstractYoung (3 months old) and aging (18-21 months old) rats were infused intracerebroventricularly with β-amyloid (1-40; 4.2 nmol) for 14 days. In both age groups, β-amyloid led to deficits in water-maze and decreased choline acetyltransferase activity and somatostatin levels. Cortical substance P levels also decreased whereas neuropeptide Y levels remained unaltered. There were no significant age dependent differences among these neurochemicals except a decrease in hippocampal neuropeptide Y levels in the aging group. It is concluded that young and aging rat brains respond similarly to β-amyloid infusion. © 2001 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/171700
ISSN
0006-8993
2023 Impact Factor: 2.7
2023 SCImago Journal Rankings: 0.832
ISI Accession Number ID
WOS:000166818800042
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorNag, Sen_US
dc.contributor.authorTang, Fen_US
dc.date.accessioned2012-10-30T06:16:28Z-
dc.date.available2012-10-30T06:16:28Z-
dc.date.issued2001en_US
dc.identifier.citationBrain Research, 2001, v. 889 n. 1-2, p. 303-307en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://hdl.handle.net/10722/171700-
dc.description.abstractYoung (3 months old) and aging (18-21 months old) rats were infused intracerebroventricularly with β-amyloid (1-40; 4.2 nmol) for 14 days. In both age groups, β-amyloid led to deficits in water-maze and decreased choline acetyltransferase activity and somatostatin levels. Cortical substance P levels also decreased whereas neuropeptide Y levels remained unaltered. There were no significant age dependent differences among these neurochemicals except a decrease in hippocampal neuropeptide Y levels in the aging group. It is concluded that young and aging rat brains respond similarly to β-amyloid infusion. © 2001 Elsevier Science B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_US
dc.relation.ispartofBrain Researchen_US
dc.subjectβ-Amyloid-
dc.subjectAging-
dc.subjectCholine acetyltransferase-
dc.subjectMemory-
dc.subjectSomatostatin-
dc.subject.meshAging - Physiologyen_US
dc.subject.meshAmyloid Beta-Peptides - Toxicityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain - Drug Effects - Growth & Developmenten_US
dc.subject.meshBrain Chemistry - Drug Effectsen_US
dc.subject.meshCholine O-Acetyltransferase - Metabolismen_US
dc.subject.meshInjections, Intraventricularen_US
dc.subject.meshMaleen_US
dc.subject.meshMaze Learning - Drug Effectsen_US
dc.subject.meshNeurotoxins - Toxicityen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.titleThe effect of age on the response of the rat brains to continuous β-amyloid infusionen_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0006-8993(00)03172-3en_US
dc.identifier.pmid11166723en_US
dc.identifier.scopuseid_2-s2.0-0035910370en_US
dc.identifier.hkuros58329-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035910370&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume889en_US
dc.identifier.issue1-2en_US
dc.identifier.spage303en_US
dc.identifier.epage307en_US
dc.identifier.isiWOS:000166818800042-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridNag, S=7103093193en_US
dc.identifier.scopusauthoridTang, F=7201979770en_US
dc.identifier.issnl0006-8993-

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