File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/S0024-3205(01)01319-4
- Scopus: eid_2-s2.0-0035964908
- PMID: 11669474
- WOS: WOS:000171327400012
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Absence of MK801-induced inspiratory prolongation in chronically hypoxic rats
Title | Absence of MK801-induced inspiratory prolongation in chronically hypoxic rats |
---|---|
Authors | |
Keywords | Chronic hypoxia Dizocilpine Glutamate receptors MK801 N-methyl-D-aspartate receptors Respiration |
Issue Date | 2001 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie |
Citation | Life Sciences, 2001, v. 69 n. 19, p. 2319-2326 How to Cite? |
Abstract | N-methyl-D-aspartate (NMDA) receptors play important roles in the neural control of respiration. We hypothesized that the brainstem circuit for respiratory control is modulated in response to chronic hypoxia during postnatal maturation, and the modulation may involve changes in the neurotransmission mediated by the NMDA receptors for inspiratory termination. Electrophysiological studies were performed on anesthetized, vagotomized, paralyzed and ventilated rats. Phrenic nerve activity was recorded in normoxic control and chronically hypoxic (CH) rats maintained in normobaric hypoxia (10% O 2) for 4-5 weeks from birth. In normoxic rats, the NMDA receptor antagonist, dizocilpine (MK801, I.P.) irreversibly increased inspiratory time (Ti) by 53% and decreased expiratory time (Te) by 29%. However, MK801 did not change the Ti, Te, respiratory rate and peak phrenic nerve activity in CH rats. Results suggest that brainstem mechanisms underlying inspiratory termination mediated by NMDA receptors are modulated by early chronic hypoxia. © 2001 Elsevier Science Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/171702 |
ISSN | 2023 Impact Factor: 5.2 2023 SCImago Journal Rankings: 1.257 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Fung, ML | en_US |
dc.contributor.author | Dong, X | en_US |
dc.date.accessioned | 2012-10-30T06:16:29Z | - |
dc.date.available | 2012-10-30T06:16:29Z | - |
dc.date.issued | 2001 | en_US |
dc.identifier.citation | Life Sciences, 2001, v. 69 n. 19, p. 2319-2326 | en_US |
dc.identifier.issn | 0024-3205 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171702 | - |
dc.description.abstract | N-methyl-D-aspartate (NMDA) receptors play important roles in the neural control of respiration. We hypothesized that the brainstem circuit for respiratory control is modulated in response to chronic hypoxia during postnatal maturation, and the modulation may involve changes in the neurotransmission mediated by the NMDA receptors for inspiratory termination. Electrophysiological studies were performed on anesthetized, vagotomized, paralyzed and ventilated rats. Phrenic nerve activity was recorded in normoxic control and chronically hypoxic (CH) rats maintained in normobaric hypoxia (10% O 2) for 4-5 weeks from birth. In normoxic rats, the NMDA receptor antagonist, dizocilpine (MK801, I.P.) irreversibly increased inspiratory time (Ti) by 53% and decreased expiratory time (Te) by 29%. However, MK801 did not change the Ti, Te, respiratory rate and peak phrenic nerve activity in CH rats. Results suggest that brainstem mechanisms underlying inspiratory termination mediated by NMDA receptors are modulated by early chronic hypoxia. © 2001 Elsevier Science Inc. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie | en_US |
dc.relation.ispartof | Life Sciences | en_US |
dc.subject | Chronic hypoxia | - |
dc.subject | Dizocilpine | - |
dc.subject | Glutamate receptors | - |
dc.subject | MK801 | - |
dc.subject | N-methyl-D-aspartate receptors | - |
dc.subject | Respiration | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Anoxia - Physiopathology | en_US |
dc.subject.mesh | Dizocilpine Maleate - Pharmacology | en_US |
dc.subject.mesh | Excitatory Amino Acid Antagonists - Pharmacology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Receptors, N-Methyl-D-Aspartate - Physiology | en_US |
dc.subject.mesh | Respiration - Drug Effects | en_US |
dc.title | Absence of MK801-induced inspiratory prolongation in chronically hypoxic rats | en_US |
dc.type | Article | en_US |
dc.identifier.email | Fung, ML:fungml@hkucc.hku.hk | en_US |
dc.identifier.authority | Fung, ML=rp00433 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/S0024-3205(01)01319-4 | en_US |
dc.identifier.pmid | 11669474 | - |
dc.identifier.scopus | eid_2-s2.0-0035964908 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0035964908&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 69 | en_US |
dc.identifier.issue | 19 | en_US |
dc.identifier.spage | 2319 | en_US |
dc.identifier.epage | 2326 | en_US |
dc.identifier.isi | WOS:000171327400012 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Fung, ML=7101955092 | en_US |
dc.identifier.scopusauthorid | Dong, X=55184171400 | en_US |
dc.identifier.issnl | 0024-3205 | - |