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- Publisher Website: 10.1046/j.1440-1819.2002.01048.x
- Scopus: eid_2-s2.0-0036791656
- PMID: 12193241
- WOS: WOS:000177597300006
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Article: Relationships between seizure duration and seizure threshold and stimulus dosage at electroconvulsive therapy: Implications for electroconvulsive therapy practice
Title | Relationships between seizure duration and seizure threshold and stimulus dosage at electroconvulsive therapy: Implications for electroconvulsive therapy practice |
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Authors | |
Keywords | Electroconvulsive therapy Seizure duration Seizure threshold Stimulus dose titration |
Issue Date | 2002 |
Publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PCN |
Citation | Psychiatry And Clinical Neurosciences, 2002, v. 56 n. 5, p. 521-526 How to Cite? |
Abstract | Recent studies cast doubt on the usefulness of seizure duration as an index for stimulus dosage adjustment at electroconvulsive therapy (ECT). A retrospective analysis on the relationships between seizure duration and seizure threshold and stimulus dosage was performed for 54 patients who received a standardized ECT dose titration and treatment protocol. Subjects receiving stimulus dosage at seizure threshold had a highly variable motor seizure duration, ranging from 15 to 89s, and 7.4% of subjects had seizures longer than 60s. Regression analysis showed that initial seizure threshold and height were independent predictors of motor seizure duration during dose titration and accounted for 34% of its variance. Stimulus dosage was increased by 40-67% between the first and second ECT session; however, 60% of subjects had no lengthening of seizures and motor seizure duration was significantly shorter at the second treatment (mean ± SD: 35.7 ± 12.3 vs 31.0 ± 10.6 s; paired t = 2.9, d.f. = 34, P = 0.006). At the first and second ECT treatment, motor seizure duration was significantly related to stimulus dosage (r=-0.45 and r= -0.41, respectively). Given the negative correlation between seizure duration and stimulus intensity, a policy that recommends an increase of stimulus dosage and its reduction for patients with short and long seizures, respectively, does not necessarily result in 'optimal' seizure duration. A better dosing policy that places less emphasis on seizure duration is proposed. |
Persistent Identifier | http://hdl.handle.net/10722/171913 |
ISSN | 2023 Impact Factor: 5.0 2023 SCImago Journal Rankings: 1.250 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Chung, KF | en_US |
dc.date.accessioned | 2012-10-30T06:18:23Z | - |
dc.date.available | 2012-10-30T06:18:23Z | - |
dc.date.issued | 2002 | en_US |
dc.identifier.citation | Psychiatry And Clinical Neurosciences, 2002, v. 56 n. 5, p. 521-526 | en_US |
dc.identifier.issn | 1323-1316 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171913 | - |
dc.description.abstract | Recent studies cast doubt on the usefulness of seizure duration as an index for stimulus dosage adjustment at electroconvulsive therapy (ECT). A retrospective analysis on the relationships between seizure duration and seizure threshold and stimulus dosage was performed for 54 patients who received a standardized ECT dose titration and treatment protocol. Subjects receiving stimulus dosage at seizure threshold had a highly variable motor seizure duration, ranging from 15 to 89s, and 7.4% of subjects had seizures longer than 60s. Regression analysis showed that initial seizure threshold and height were independent predictors of motor seizure duration during dose titration and accounted for 34% of its variance. Stimulus dosage was increased by 40-67% between the first and second ECT session; however, 60% of subjects had no lengthening of seizures and motor seizure duration was significantly shorter at the second treatment (mean ± SD: 35.7 ± 12.3 vs 31.0 ± 10.6 s; paired t = 2.9, d.f. = 34, P = 0.006). At the first and second ECT treatment, motor seizure duration was significantly related to stimulus dosage (r=-0.45 and r= -0.41, respectively). Given the negative correlation between seizure duration and stimulus intensity, a policy that recommends an increase of stimulus dosage and its reduction for patients with short and long seizures, respectively, does not necessarily result in 'optimal' seizure duration. A better dosing policy that places less emphasis on seizure duration is proposed. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PCN | en_US |
dc.relation.ispartof | Psychiatry and Clinical Neurosciences | en_US |
dc.subject | Electroconvulsive therapy | - |
dc.subject | Seizure duration | - |
dc.subject | Seizure threshold | - |
dc.subject | Stimulus dose titration | - |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Aged, 80 And Over | en_US |
dc.subject.mesh | Electroconvulsive Therapy - Methods | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Retrospective Studies | en_US |
dc.subject.mesh | Seizures - Etiology - Physiopathology | en_US |
dc.subject.mesh | Time Factors | en_US |
dc.title | Relationships between seizure duration and seizure threshold and stimulus dosage at electroconvulsive therapy: Implications for electroconvulsive therapy practice | en_US |
dc.type | Article | en_US |
dc.identifier.email | Chung, KF:kfchung@hkucc.hku.hk | en_US |
dc.identifier.authority | Chung, KF=rp00377 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1046/j.1440-1819.2002.01048.x | en_US |
dc.identifier.pmid | 12193241 | - |
dc.identifier.scopus | eid_2-s2.0-0036791656 | en_US |
dc.identifier.hkuros | 82477 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0036791656&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 56 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 521 | en_US |
dc.identifier.epage | 526 | en_US |
dc.identifier.isi | WOS:000177597300006 | - |
dc.publisher.place | Australia | en_US |
dc.identifier.scopusauthorid | Chung, KF=7404086681 | en_US |
dc.identifier.issnl | 1323-1316 | - |