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Article: Estimation of vaccine efficacy and the vaccination threshold

TitleEstimation of vaccine efficacy and the vaccination threshold
Authors
Yip, PSFWatson, RChen, Q
KeywordsCounting process models
Epidemic model
Threshold value
Vaccine efficacy
Zero mean martingale
Issue Date2007
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0277-6715/
Citation
Statistics In Medicine, 2007, v. 26 n. 24, p. 4475-4488 How to Cite?
DOI: http://dx.doi.org/10.1002/sim.2874
AbstractThis paper considers the effect of imperfect vaccination in a susceptible-infected-removal (SIR) epidemic model. The minimum proportion of the population that needs to be vaccinated to prevent a major epidemic depends on the vaccine efficacy and the basic reproductive rate for the SIR model, allowing for imperfect and variable vaccination. Martingale theory is used to derive estimates and associated standard errors for these parameters. Asymptotic properties of the resulting estimators are investigated. Data for a mumps outbreak are used as an illustrative example. Copyright © 2007 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/172172
ISSN
0277-6715
2021 Impact Factor: 2.497
2020 SCImago Journal Rankings: 1.996
ISI Accession Number ID
WOS:000250158100008
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorYip, PSFen_US
dc.contributor.authorWatson, Ren_US
dc.contributor.authorChen, Qen_US
dc.date.accessioned2012-10-30T06:20:31Z-
dc.date.available2012-10-30T06:20:31Z-
dc.date.issued2007en_US
dc.identifier.citationStatistics In Medicine, 2007, v. 26 n. 24, p. 4475-4488en_US
dc.identifier.issn0277-6715en_US
dc.identifier.urihttp://hdl.handle.net/10722/172172-
dc.description.abstractThis paper considers the effect of imperfect vaccination in a susceptible-infected-removal (SIR) epidemic model. The minimum proportion of the population that needs to be vaccinated to prevent a major epidemic depends on the vaccine efficacy and the basic reproductive rate for the SIR model, allowing for imperfect and variable vaccination. Martingale theory is used to derive estimates and associated standard errors for these parameters. Asymptotic properties of the resulting estimators are investigated. Data for a mumps outbreak are used as an illustrative example. Copyright © 2007 John Wiley & Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0277-6715/en_US
dc.relation.ispartofStatistics in Medicineen_US
dc.subjectCounting process models-
dc.subjectEpidemic model-
dc.subjectThreshold value-
dc.subjectVaccine efficacy-
dc.subjectZero mean martingale-
dc.subject.meshDisease Outbreaks - Prevention & Control - Statistics & Numerical Dataen_US
dc.subject.meshHumansen_US
dc.subject.meshModels, Statisticalen_US
dc.subject.meshMumps - Epidemiology - Prevention & Controlen_US
dc.subject.meshMumps Vaccine - Pharmacologyen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshVaccination - Statistics & Numerical Dataen_US
dc.subject.meshVaccines - Pharmacologyen_US
dc.titleEstimation of vaccine efficacy and the vaccination thresholden_US
dc.typeArticleen_US
dc.identifier.emailYip, PSF: sfpyip@hku.hken_US
dc.identifier.authorityYip, PSF=rp00596en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/sim.2874en_US
dc.identifier.pmid17348084-
dc.identifier.scopuseid_2-s2.0-35148863405en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35148863405&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume26en_US
dc.identifier.issue24en_US
dc.identifier.spage4475en_US
dc.identifier.epage4488en_US
dc.identifier.isiWOS:000250158100008-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridYip, PSF=7102503720en_US
dc.identifier.scopusauthoridWatson, R=7403653677en_US
dc.identifier.scopusauthoridChen, Q=7406335304en_US
dc.identifier.issnl0277-6715-

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