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Article: Dopamine D3 receptor gene and tardive dyskinesia in Chinese schizophrenic patients

TitleDopamine D3 receptor gene and tardive dyskinesia in Chinese schizophrenic patients
Authors
GarciaBarceló, MMLam, LCWUngvari, GSLam, VKLTang, WK
KeywordsD3 receptor gene
Genetic polymorphism
Schizophrenia
Tardive dyskinesia
Issue Date2001
PublisherSpringer-Verlag Wien. The Journal's web site is located at http://www.springer.at/jnt
Citation
Journal Of Neural Transmission, 2001, v. 108 n. 6, p. 671-677 How to Cite?
DOI: http://dx.doi.org/10.1007/s007020170044
AbstractEpidemiological studies have shown a lower prevalence of tardive dyskinesia (TD) among Chinese psychiatric patients compared to Caucasian and Black patient populations. It has been hypothesized that pharmacogenetic factors may underlie this cross-cultural difference. Due to the important implications of the dopamine D3 receptor gene (DRD3) in motor control, we investigated the frequency of polymorphic serine (ser) to glycine (gly) substitution of the gene DRD3 in Chinese schizophrenic patients. The sample size consisted of 65 patients with TD and 66 without TD. Patients were assessed for the severity of TD, the presence of akathisia and parkinsonian symptoms and were subsequently genotyped. We found no evidence that the dopamine D3 receptor gene is likely to confer susceptibility to the development of tardive dyskinesia in Chinese patients with schizophrenia.
Persistent Identifierhttp://hdl.handle.net/10722/172784
ISSN
0300-9564
2023 Impact Factor: 3.2
2023 SCImago Journal Rankings: 0.942
ISI Accession Number ID
WOS:000169446600007
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorGarciaBarceló, MMen_US
dc.contributor.authorLam, LCWen_US
dc.contributor.authorUngvari, GSen_US
dc.contributor.authorLam, VKLen_US
dc.contributor.authorTang, WKen_US
dc.date.accessioned2012-10-30T06:24:55Z-
dc.date.available2012-10-30T06:24:55Z-
dc.date.issued2001en_US
dc.identifier.citationJournal Of Neural Transmission, 2001, v. 108 n. 6, p. 671-677en_US
dc.identifier.issn0300-9564en_US
dc.identifier.urihttp://hdl.handle.net/10722/172784-
dc.description.abstractEpidemiological studies have shown a lower prevalence of tardive dyskinesia (TD) among Chinese psychiatric patients compared to Caucasian and Black patient populations. It has been hypothesized that pharmacogenetic factors may underlie this cross-cultural difference. Due to the important implications of the dopamine D3 receptor gene (DRD3) in motor control, we investigated the frequency of polymorphic serine (ser) to glycine (gly) substitution of the gene DRD3 in Chinese schizophrenic patients. The sample size consisted of 65 patients with TD and 66 without TD. Patients were assessed for the severity of TD, the presence of akathisia and parkinsonian symptoms and were subsequently genotyped. We found no evidence that the dopamine D3 receptor gene is likely to confer susceptibility to the development of tardive dyskinesia in Chinese patients with schizophrenia.en_US
dc.languageengen_US
dc.publisherSpringer-Verlag Wien. The Journal's web site is located at http://www.springer.at/jnten_US
dc.relation.ispartofJournal of Neural Transmissionen_US
dc.subjectD3 receptor gene-
dc.subjectGenetic polymorphism-
dc.subjectSchizophrenia-
dc.subjectTardive dyskinesia-
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntipsychotic Agents - Adverse Effectsen_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshDyskinesia, Drug-Induced - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshReceptors, Dopamine D2 - Geneticsen_US
dc.subject.meshReceptors, Dopamine D3en_US
dc.subject.meshSchizophrenia - Drug Therapy - Geneticsen_US
dc.titleDopamine D3 receptor gene and tardive dyskinesia in Chinese schizophrenic patientsen_US
dc.typeArticleen_US
dc.identifier.emailGarciaBarceló, MM: mmgarcia@hkucc.hku.hken_US
dc.identifier.authorityGarciaBarceló, MM=rp00445en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s007020170044en_US
dc.identifier.pmid11478419-
dc.identifier.scopuseid_2-s2.0-0034920248en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034920248&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume108en_US
dc.identifier.issue6en_US
dc.identifier.spage671en_US
dc.identifier.epage677en_US
dc.identifier.isiWOS:000169446600007-
dc.publisher.placeAustriaen_US
dc.identifier.scopusauthoridGarciaBarceló, MM=6701767303en_US
dc.identifier.scopusauthoridLam, LCW=7201984627en_US
dc.identifier.scopusauthoridUngvari, GS=7006092063en_US
dc.identifier.scopusauthoridLam, VKL=25655156200en_US
dc.identifier.scopusauthoridTang, WK=7403430796en_US
dc.identifier.issnl0300-9564-

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